BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

284 related articles for article (PubMed ID: 33821673)

  • 1. Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin.
    Sun K; Sun Z; Zhao F; Shan G; Meng Q
    Future Med Chem; 2021 May; 13(9):839-858. PubMed ID: 33821673
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance.
    Cheng B; Zhu G; Meng L; Wu G; Chen Q; Ma S
    Eur J Med Chem; 2022 Jan; 228():113930. PubMed ID: 34794817
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
    Wang Y; Zhang H; Gigant B; Yu Y; Wu Y; Chen X; Lai Q; Yang Z; Chen Q; Yang J
    FEBS J; 2016 Jan; 283(1):102-11. PubMed ID: 26462166
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of potent microtubule-destabilizing agents targeting for colchicine site by virtual screening, biological evaluation, and molecular dynamics simulation.
    Zhang H; Luo QQ; Hu ML; Wang N; Qi HZ; Zhang HR; Ding L
    Eur J Pharm Sci; 2023 Jan; 180():106340. PubMed ID: 36435355
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Targeting Tubulin-colchicine Site for Cancer Therapy: Inhibitors, Antibody- Drug Conjugates and Degradation Agents.
    Duan Y; Liu W; Tian L; Mao Y; Song C
    Curr Top Med Chem; 2019; 19(15):1289-1304. PubMed ID: 31210108
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
    Du T; Lin S; Ji M; Xue N; Liu Y; Zhang Z; Zhang K; Zhang J; Zhang Y; Wang Q; Sheng L; Li Y; Lu D; Chen X; Xu H
    Cancer Lett; 2020 Dec; 495():22-32. PubMed ID: 32931884
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.
    Majcher U; Urbaniak A; Maj E; Moshari M; Delgado M; Wietrzyk J; Bartl F; Chambers TC; Tuszynski JA; Huczyński A
    Bioorg Chem; 2018 Dec; 81():553-566. PubMed ID: 30248507
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Recent Advances in Heterocyclic Tubulin Inhibitors Targeting the Colchicine Binding Site.
    Wu X; Wang Q; Li W
    Anticancer Agents Med Chem; 2016; 16(10):1325-38. PubMed ID: 26899186
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance.
    Aoyama A; Katayama R; Oh-Hara T; Sato S; Okuno Y; Fujita N
    Mol Cancer Ther; 2014 Dec; 13(12):2978-90. PubMed ID: 25313010
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural insights into the design of indole derivatives as tubulin polymerization inhibitors.
    Li Y; Yang J; Niu L; Hu D; Li H; Chen L; Yu Y; Chen Q
    FEBS Lett; 2020 Jan; 594(1):199-204. PubMed ID: 31369682
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin.
    Bhattacharyya B; Panda D; Gupta S; Banerjee M
    Med Res Rev; 2008 Jan; 28(1):155-83. PubMed ID: 17464966
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.
    Maklad RM; AbdelHafez EMN; Abdelhamid D; Aly OM
    Bioorg Chem; 2020 Jun; 99():103767. PubMed ID: 32325332
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site.
    Lai Q; Wang Y; Wang R; Lai W; Tang L; Tao Y; Liu Y; Zhang R; Huang L; Xiang H; Zeng S; Gou L; Chen H; Yao Y; Yang J
    Eur J Med Chem; 2018 Aug; 156():162-179. PubMed ID: 30006162
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization.
    Prota AE; Danel F; Bachmann F; Bargsten K; Buey RM; Pohlmann J; Reinelt S; Lane H; Steinmetz MO
    J Mol Biol; 2014 Apr; 426(8):1848-60. PubMed ID: 24530796
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis and biological evaluation of colchicine glycoconjugates as tubulin polymerization inhibitors.
    Wang Z; Liu R; Zhang X; Chang X; Gao M; Zhang S; Guan Q; Sun J; Zuo D; Zhang W
    Bioorg Med Chem; 2022 Mar; 58():116671. PubMed ID: 35193066
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo.
    Cui YJ; Ma CC; Zhang CM; Tang LQ; Liu ZP
    Eur J Med Chem; 2020 Feb; 187():111968. PubMed ID: 31865012
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural insight into SSE15206 in complex with tubulin provides a rational design for pyrazolinethioamides as tubulin polymerization inhibitors.
    Ma L; Lei J; Chen H; Huang R; Su T; Feng J; Sun Q
    Future Med Chem; 2022 Jun; 14(11):785-794. PubMed ID: 35506429
    [No Abstract]   [Full Text] [Related]  

  • 18. SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines.
    Yan W; Yang T; Yang J; Wang T; Yu Y; Wang Y; Chen Q; Bai P; Li D; Ye H; Qiu Q; Zhou Y; Hu Y; Yang S; Wei Y; Li W; Chen L
    Cell Physiol Biochem; 2018; 47(2):489-504. PubMed ID: 29794416
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site.
    Li L; Jiang S; Li X; Liu Y; Su J; Chen J
    Eur J Med Chem; 2018 May; 151():482-494. PubMed ID: 29649743
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors.
    Sardaru MC; Craciun AM; Al Matarneh CM; Sandu IA; Amarandi RM; Popovici L; Ciobanu CI; Peptanariu D; Pinteala M; Mangalagiu II; Danac R
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):1581-1595. PubMed ID: 32752898
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.