BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

197 related articles for article (PubMed ID: 33838610)

  • 1. Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.
    Sun M; Zhao J; Mao Q; Yan C; Zhang B; Yang Y; Dai X; Gao J; Lin F; Duan Y; Zhang T; Wang S
    Bioorg Med Chem; 2021 May; 38():116117. PubMed ID: 33838610
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.
    Mao Q; Dai X; Xu G; Su Y; Zhang B; Liu D; Wang S
    Eur J Med Chem; 2019 Nov; 181():111558. PubMed ID: 31369933
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.
    Zhang B; Dai X; Bao Z; Mao Q; Duan Y; Yang Y; Wang S
    Eur J Med Chem; 2019 Nov; 181():111559. PubMed ID: 31376568
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.
    Zhao J; Mao Q; Lin F; Zhang B; Sun M; Zhang T; Wang S
    Eur J Med Chem; 2022 Feb; 229():114086. PubMed ID: 34992040
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
    Gao J; Liu X; Zhang B; Mao Q; Zhang Z; Zou Q; Dai X; Wang S
    Eur J Med Chem; 2020 Mar; 190():112077. PubMed ID: 32014678
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
    Zhang B; Duan Y; Yang Y; Mao Q; Lin F; Gao J; Dai X; Zhang P; Li Q; Li J; Dai R; Wang S
    Eur J Med Chem; 2022 Jan; 227():113928. PubMed ID: 34688012
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors.
    Shi A; Zhang L; Wang H; Wang S; Yang M; Guan Q; Bao K; Zhang W
    Eur J Med Chem; 2018 Jul; 155():590-595. PubMed ID: 29920453
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors.
    Chen S; Zhang T; Wang J; Wang F; Niu H; Wu C; Wang S
    Eur J Med Chem; 2015 Oct; 103():343-53. PubMed ID: 26363870
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.
    Gao J; Zhang Z; Zhang B; Mao Q; Dai X; Zou Q; Lei Y; Feng Y; Wang S
    Bioorg Chem; 2020 Jan; 95():103564. PubMed ID: 31927335
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthine oxidase inhibitors.
    Zhang T; Lv Y; Lei Y; Liu D; Feng Y; Zhao J; Chen S; Meng F; Wang S
    Eur J Med Chem; 2018 Feb; 146():668-677. PubMed ID: 29407989
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor.
    Kaur M; Kaur A; Mankotia S; Singh H; Singh A; Singh JV; Gupta MK; Sharma S; Nepali K; Bedi PMS
    Eur J Med Chem; 2017 May; 131():14-28. PubMed ID: 28286211
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis and biological evaluation of N-(4-alkoxy-3-cyanophenyl)isonicotinamide/nicotinamide derivatives as novel xanthine oxidase inhibitors.
    Zhang TJ; Li SY; Wang L; Sun Q; Wu QX; Zhang Y; Meng FH
    Eur J Med Chem; 2017 Dec; 141():362-372. PubMed ID: 29032030
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors.
    Shi DH; Huang W; Li C; Liu YW; Wang SF
    Eur J Med Chem; 2014 Mar; 75():289-96. PubMed ID: 24556143
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and evaluation of 1-phenyl-1H-1,2,3-triazole-4-carboxylic acid derivatives as xanthine oxidase inhibitors.
    Zhang TJ; Wu QX; Li SY; Wang L; Sun Q; Zhang Y; Meng FH; Gao H
    Bioorg Med Chem Lett; 2017 Aug; 27(16):3812-3816. PubMed ID: 28693909
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and Biological Evaluation of Novel Aryl-2H-pyrazole Derivatives as Potent Non-purine Xanthine Oxidase Inhibitors.
    Sun ZG; Zhou XJ; Zhu ML; Ding WZ; Li Z; Zhu HL
    Chem Pharm Bull (Tokyo); 2015; 63(8):603-7. PubMed ID: 26040271
    [TBL] [Abstract][Full Text] [Related]  

  • 16.
    Malik N; Dhiman P; Khatkar A
    Curr Drug Targets; 2019; 20(5):593-603. PubMed ID: 30465499
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Amide-based xanthine oxidase inhibitors bearing an N-(1-alkyl-3-cyano-1H-indol-5-yl) moiety: Design, synthesis and structure-activity relationship investigation.
    Zhang TJ; Tu S; Zhang X; Wang QY; Hu SS; Zhang Y; Zhang ZH; Wang ZR; Meng FH
    Bioorg Chem; 2021 Dec; 117():105417. PubMed ID: 34673452
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.
    Zhang TJ; Zhang Y; Zhang ZH; Wang ZR; Zhang X; Hu SS; Lu PF; Guo S; Meng FH
    Bioorg Med Chem Lett; 2022 Mar; 60():128582. PubMed ID: 35077850
    [TBL] [Abstract][Full Text] [Related]  

  • 19. N-(3-cyano-1H-indol-5-yl)isonicotinamide and N-(3-cyano-1H-indol-5-yl)-1H-benzo[d]imidazole-5-carboxamide derivatives: Novel amide-based xanthine oxidase inhibitors.
    Tu S; Zhang TJ; Zhang Y; Zhang X; Zhang ZH; Meng FH
    Bioorg Chem; 2021 Oct; 115():105181. PubMed ID: 34329991
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.
    Ishibuchi S; Morimoto H; Oe T; Ikebe T; Inoue H; Fukunari A; Kamezawa M; Yamada I; Naka Y
    Bioorg Med Chem Lett; 2001 Apr; 11(7):879-82. PubMed ID: 11294382
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.