These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

336 related articles for article (PubMed ID: 33852845)

  • 1. eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
    Liang Y; Piao C; Beuschel CB; Toppe D; Kollipara L; Bogdanow B; Maglione M; Lützkendorf J; See JCK; Huang S; Conrad TOF; Kintscher U; Madeo F; Liu F; Sickmann A; Sigrist SJ
    Cell Rep; 2021 Apr; 35(2):108941. PubMed ID: 33852845
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma.
    Schultz CR; Geerts D; Mooney M; El-Khawaja R; Koster J; Bachmann AS
    Biochem J; 2018 Jan; 475(2):531-545. PubMed ID: 29295892
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
    Oliverio S; Corazzari M; Sestito C; Piredda L; Ippolito G; Piacentini M
    Amino Acids; 2014 Dec; 46(12):2767-76. PubMed ID: 25218134
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
    Hyvönen MT; Khomutov M; Petit M; Weisell J; Kochetkov SN; Alhonen L; Vepsäläinen J; Khomutov AR; Keinänen TA
    ACS Chem Biol; 2015 Jun; 10(6):1417-24. PubMed ID: 25689365
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Many Faces of Hypusinated eIF5A: Cell Context-Specific Effects of the Hypusine Circuit and Implications for Human Health.
    Nakanishi S; Cleveland JL
    Int J Mol Sci; 2024 Jul; 25(15):. PubMed ID: 39125743
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
    Wolff EC; Kang KR; Kim YS; Park MH
    Amino Acids; 2007 Aug; 33(2):341-50. PubMed ID: 17476569
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy.
    Bourourou M; Gouix E; Melis N; Friard J; Heurteaux C; Tauc M; Blondeau N
    J Cereb Blood Flow Metab; 2021 May; 41(5):1080-1090. PubMed ID: 32615885
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.
    Patel PH; Costa-Mattioli M; Schulze KL; Bellen HJ
    J Cell Biol; 2009 Jun; 185(7):1181-94. PubMed ID: 19546244
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment.
    Park MH; Kar RK; Banka S; Ziegler A; Chung WK
    Amino Acids; 2022 Apr; 54(4):485-499. PubMed ID: 34273022
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A).
    Park MH
    J Biochem; 2006 Feb; 139(2):161-9. PubMed ID: 16452303
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The effect of hypusine modification on the intracellular localization of eIF5A.
    Lee SB; Park JH; Kaevel J; Sramkova M; Weigert R; Park MH
    Biochem Biophys Res Commun; 2009 Jun; 383(4):497-502. PubMed ID: 19379712
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Functional significance of eIF5A and its hypusine modification in eukaryotes.
    Park MH; Nishimura K; Zanelli CF; Valentini SR
    Amino Acids; 2010 Feb; 38(2):491-500. PubMed ID: 19997760
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation.
    Coni S; Serrao SM; Yurtsever ZN; Di Magno L; Bordone R; Bertani C; Licursi V; Ianniello Z; Infante P; Moretti M; Petroni M; Guerrieri F; Fatica A; Macone A; De Smaele E; Di Marcotullio L; Giannini G; Maroder M; Agostinelli E; Canettieri G
    Cell Death Dis; 2020 Dec; 11(12):1045. PubMed ID: 33303756
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.
    Zhou J; Pang J; Tripathi M; Ho JP; Widjaja AA; Shekeran SG; Cook SA; Suzuki A; Diehl AM; Petretto E; Singh BK; Yen PM
    Nat Commun; 2022 Sep; 13(1):5202. PubMed ID: 36057633
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A.
    Gonzalez-Menendez P; Phadke I; Olive ME; Joly A; Papoin J; Yan H; Galtier J; Platon J; Kang SWS; McGraw KL; Daumur M; Pouzolles M; Kondo T; Boireau S; Paul F; Young DJ; Lamure S; Mirmira RG; Narla A; Cartron G; Dunbar CE; Boyer-Clavel M; Porat-Shliom N; Dardalhon V; Zimmermann VS; Sitbon M; Dever TE; Mohandas N; Da Costa L; Udeshi ND; Blanc L; Kinet S; Taylor N
    Blood; 2023 May; 141(20):2520-2536. PubMed ID: 36735910
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins.
    Nguyen S; Leija C; Kinch L; Regmi S; Li Q; Grishin NV; Phillips MA
    J Biol Chem; 2015 Aug; 290(32):19987-98. PubMed ID: 26082486
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
    Hyvönen MT; Keinänen TA; Khomutov M; Simonian A; Vepsäläinen J; Park JH; Khomutov AR; Alhonen L; Park MH
    Amino Acids; 2012 Feb; 42(2-3):685-95. PubMed ID: 21861168
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Spermidine Regulates Mitochondrial Function by Enhancing eIF5A Hypusination and Contributes to Reactive Oxygen Species Production and Ganoderic Acid Biosynthesis in Ganoderma lucidum.
    Han X; Shangguan J; Wang Z; Li Y; Fan J; Ren A; Zhao M
    Appl Environ Microbiol; 2022 Mar; 88(6):e0203721. PubMed ID: 35108082
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).
    Lee SB; Park JH; Folk JE; Deck JA; Pegg AE; Sokabe M; Fraser CS; Park MH
    Biochem J; 2011 Jan; 433(1):205-13. PubMed ID: 20942800
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
    Zhang H; Alsaleh G; Feltham J; Sun Y; Napolitano G; Riffelmacher T; Charles P; Frau L; Hublitz P; Yu Z; Mohammed S; Ballabio A; Balabanov S; Mellor J; Simon AK
    Mol Cell; 2019 Oct; 76(1):110-125.e9. PubMed ID: 31474573
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.