BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

307 related articles for article (PubMed ID: 33855276)

  • 1. Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy.
    Li J; Liu S; Shi J; Wang X; Xue Y; Zhu HJ
    ACS Pharmacol Transl Sci; 2021 Apr; 4(2):870-887. PubMed ID: 33855276
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2.
    Mackman RL
    ACS Med Chem Lett; 2022 Mar; 13(3):338-347. PubMed ID: 35291757
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection.
    Li J; Liu S; Shi J; Zhu HJ
    Pharmaceutics; 2021 Oct; 13(10):. PubMed ID: 34683949
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2.
    Wei D; Hu T; Zhang Y; Zheng W; Xue H; Shen J; Xie Y; Aisa HA
    Bioorg Med Chem; 2021 Sep; 46():116364. PubMed ID: 34450570
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Advancement of Prodrug Approaches for Nucleotide Antiviral Agents.
    Li Y; Yang B; Quan Y; Li Z
    Curr Top Med Chem; 2021; 21(32):2909-2927. PubMed ID: 34323189
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue.
    Gupta D; Varghese Gupta S; Dahan A; Tsume Y; Hilfinger J; Lee KD; Amidon GL
    Mol Pharm; 2013 Feb; 10(2):512-22. PubMed ID: 23244438
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys.
    Mackman RL; Kalla RV; Babusis D; Pitts J; Barrett KT; Chun K; Du Pont V; Rodriguez L; Moshiri J; Xu Y; Lee M; Lee G; Bleier B; Nguyen AQ; O'Keefe BM; Ambrosi A; Cook M; Yu J; Dempah KE; Bunyan E; Riola NC; Lu X; Liu R; Davie A; Hsiang TY; Dearing J; Vermillion M; Gale M; Niedziela-Majka A; Feng JY; Hedskog C; Bilello JP; Subramanian R; Cihlar T
    J Med Chem; 2023 Sep; 66(17):11701-11717. PubMed ID: 37596939
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.
    Li R; Liclican A; Xu Y; Pitts J; Niu C; Zhang J; Kim C; Zhao X; Soohoo D; Babusis D; Yue Q; Ma B; Murray BP; Subramanian R; Xie X; Zou J; Bilello JP; Li L; Schultz BE; Sakowicz R; Smith BJ; Shi PY; Murakami E; Feng JY
    Antimicrob Agents Chemother; 2021 Aug; 65(9):e0060221. PubMed ID: 34125594
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity.
    Hu H; Mady Traore MD; Li R; Yuan H; He M; Wen B; Gao W; Jonsson CB; Fitzpatrick EA; Sun D
    J Med Chem; 2022 Sep; 65(18):12044-12054. PubMed ID: 36070561
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment.
    Feng JY; Wang T; Park Y; Babusis D; Birkus G; Xu Y; Voitenleitner C; Fenaux M; Yang H; Eng S; Tirunagari N; Kirschberg T; Cho A; Ray AS
    Antimicrob Agents Chemother; 2018 Aug; 62(8):. PubMed ID: 29866875
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years.
    Sinokrot H; Smerat T; Najjar A; Karaman R
    Molecules; 2017 Oct; 22(10):. PubMed ID: 29035325
    [No Abstract]   [Full Text] [Related]  

  • 12. Nucleoside ester prodrug substrate specificity of liver carboxylesterase.
    Landowski CP; Lorenzi PL; Song X; Amidon GL
    J Pharmacol Exp Ther; 2006 Feb; 316(2):572-80. PubMed ID: 16223870
    [TBL] [Abstract][Full Text] [Related]  

  • 13. AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2
    Good SS; Westover J; Jung KH; Zhou XJ; Moussa A; La Colla P; Collu G; Canard B; Sommadossi JP
    Antimicrob Agents Chemother; 2021 Mar; 65(4):. PubMed ID: 33558299
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Metabolism of Nucleosides and Nucleotides Prodrugs.
    De Schutter C; Ehteshami M; Hammond ET; Amblard F; Schinazi RF
    Curr Pharm Des; 2017 Oct; ():. PubMed ID: 29022511
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'-
    Karuna R; Yokokawa F; Wang K; Zhang J; Xu H; Wang G; Ding M; Chan WL; Abdul Ghafar N; Leonardi A; Seh CC; Seah PG; Liu W; Srinivasa RPS; Lim SP; Lakshminarayana SB; Growcott E; Babu S; Fenaux M; Zhong W; Gu F; Shi PY; Blasco F; Chen YL
    Antimicrob Agents Chemother; 2020 Nov; 64(12):. PubMed ID: 32958712
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Expanding the toolbox of metabolically stable lipid prodrug strategies.
    Toti KS; Pribut N; D'Erasmo M; Dasari M; Sharma SK; Bartsch PW; Burton SL; Gold HB; Bushnev A; Derdeyn CA; Basson AE; Liotta DC; Miller EJ
    Front Pharmacol; 2022; 13():1083284. PubMed ID: 36686712
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate.
    Prueksaritanont T; Gorham LM; Breslin MJ; Hutchinson JH; Hartman GD; Vyas KP; Baillie TA
    Drug Metab Dispos; 1997 Aug; 25(8):978-84. PubMed ID: 9280406
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Enzymatic activation of double-targeted 5'-O-L-valyl-decitabine prodrug by biphenyl hydrolase-like protein and its molecular design basis.
    Tao W; Zhao D; Sun M; Li M; Zhang X; He Z; Sun Y; Sun J
    Drug Deliv Transl Res; 2017 Apr; 7(2):304-311. PubMed ID: 28070705
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies.
    Hillaireau H; Dereuddre-Bosquet N; Skanji R; Bekkara-Aounallah F; Caron J; Lepêtre S; Argote S; Bauduin L; Yousfi R; Rogez-Kreuz C; Desmaële D; Rousseau B; Gref R; Andrieux K; Clayette P; Couvreur P
    Biomaterials; 2013 Jul; 34(20):4831-8. PubMed ID: 23562054
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.
    Han H; de Vrueh RL; Rhie JK; Covitz KM; Smith PL; Lee CP; Oh DM; Sadée W; Amidon GL
    Pharm Res; 1998 Aug; 15(8):1154-9. PubMed ID: 9706043
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.