BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

207 related articles for article (PubMed ID: 33863723)

  • 1. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies.
    Chen G; Kang SS; Wang Z; Ahn EH; Xia Y; Liu X; Sandoval IM; Manfredsson FP; Zhang Z; Ye K
    Sci Adv; 2021 Apr; 7(16):. PubMed ID: 33863723
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling.
    Hashimoto Y; Toyama Y; Kusakari S; Nawa M; Matsuoka M
    J Biol Chem; 2016 Jun; 291(23):12282-93. PubMed ID: 27068745
    [TBL] [Abstract][Full Text] [Related]  

  • 3. TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies.
    Xia Y; Wang ZH; Liu P; Edgington-Mitchell L; Liu X; Wang XC; Ye K
    Mol Psychiatry; 2021 Jul; 26(7):2943-2963. PubMed ID: 32782380
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
    Wetzel-Smith MK; Hunkapiller J; Bhangale TR; Srinivasan K; Maloney JA; Atwal JK; Sa SM; Yaylaoglu MB; Foreman O; Ortmann W; Rathore N; Hansen DV; Tessier-Lavigne M; ; Mayeux R; Pericak-Vance M; Haines J; Farrer LA; Schellenberg GD; Goate A; Behrens TW; Cruchaga C; Watts RJ; Graham RR
    Nat Med; 2014 Dec; 20(12):1452-7. PubMed ID: 25419706
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer's disease.
    Wang H; Liu X; Chen S; Ye K
    Proc Natl Acad Sci U S A; 2018 Dec; 115(52):E12427-E12434. PubMed ID: 30530690
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
    Wang ZH; Liu P; Liu X; Manfredsson FP; Sandoval IM; Yu SP; Wang JZ; Ye K
    Mol Cell; 2017 Sep; 67(5):812-825.e5. PubMed ID: 28826672
    [TBL] [Abstract][Full Text] [Related]  

  • 7. UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease.
    Chen G; Ahn EH; Kang SS; Xia Y; Liu X; Zhang Z; Ye K
    Adv Sci (Weinh); 2022 Mar; 9(7):e2103396. PubMed ID: 35023303
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling.
    Shao Q; Yang T; Huang H; Majumder T; Khot BA; Khouzani MM; Alarmanazi F; Gore YK; Liu G
    PLoS One; 2019; 14(6):e0218811. PubMed ID: 31226147
    [TBL] [Abstract][Full Text] [Related]  

  • 9. C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
    Wang ZH; Gong K; Liu X; Zhang Z; Sun X; Wei ZZ; Yu SP; Manfredsson FP; Sandoval IM; Johnson PF; Jia J; Wang JZ; Ye K
    Nat Commun; 2018 May; 9(1):1784. PubMed ID: 29725016
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice.
    Barroca V; Racine C; Pays L; Fouchet P; Coureuil M; Allemand I
    Stem Cell Res; 2022 Apr; 60():102723. PubMed ID: 35247845
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
    Shao Q; Yang T; Huang H; Alarmanazi F; Liu G
    J Neurosci; 2017 Jun; 37(23):5620-5633. PubMed ID: 28483977
    [TBL] [Abstract][Full Text] [Related]  

  • 12. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease.
    Zhang Z; Li XG; Wang ZH; Song M; Yu SP; Kang SS; Liu X; Zhang Z; Xie M; Liu GP; Wang JZ; Ye K
    Mol Psychiatry; 2021 Feb; 26(2):586-603. PubMed ID: 30382187
    [TBL] [Abstract][Full Text] [Related]  

  • 13.
    Treccarichi S; Failla P; Vinci M; Musumeci A; Gloria A; Vasta A; Calabrese G; Papa C; Federico C; Saccone S; Calì F
    Genes (Basel); 2024 Feb; 15(3):. PubMed ID: 38540364
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies.
    Yao Y; Kang SS; Xia Y; Wang ZH; Liu X; Muller T; Sun YE; Ye K
    Brain; 2021 Jul; 144(6):1833-1852. PubMed ID: 33880508
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease.
    Zhang Z; Song M; Liu X; Su Kang S; Duong DM; Seyfried NT; Cao X; Cheng L; Sun YE; Ping Yu S; Jia J; Levey AI; Ye K
    Nat Commun; 2015 Nov; 6():8762. PubMed ID: 26549211
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease.
    Wang ZH; Xiang J; Liu X; Yu SP; Manfredsson FP; Sandoval IM; Wu S; Wang JZ; Ye K
    Cell Rep; 2019 Jul; 28(3):655-669.e5. PubMed ID: 31315045
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
    Wu Z; Liu X; Cheng L; Ye K
    Cell Death Dis; 2020 Dec; 11(12):1058. PubMed ID: 33311478
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology.
    Wu Z; Wang ZH; Liu X; Zhang Z; Gu X; Yu SP; Keene CD; Cheng L; Ye K
    Prog Neurobiol; 2020 Feb; 185():101730. PubMed ID: 31778772
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease.
    Wang ZH; Xia Y; Liu P; Liu X; Edgington-Mitchell L; Lei K; Yu SP; Wang XC; Ye K
    Prog Neurobiol; 2021 Jul; 202():102032. PubMed ID: 33716161
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease.
    Liao J; Chen C; Ahn EH; Liu X; Li H; Edgington-Mitchell LE; Lu Z; Ming S; Ye K
    Neuropharmacology; 2021 Oct; 197():108737. PubMed ID: 34343610
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.