185 related articles for article (PubMed ID: 33871049)
1. Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor.
Shenkman M; Geva M; Gershoni-Emek N; Hayden MR; Lederkremer GZ
J Neurochem; 2021 Jul; 158(2):467-481. PubMed ID: 33871049
[TBL] [Abstract][Full Text] [Related]
2. The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.
Ryskamp D; Wu J; Geva M; Kusko R; Grossman I; Hayden M; Bezprozvanny I
Neurobiol Dis; 2017 Jan; 97(Pt A):46-59. PubMed ID: 27818324
[TBL] [Abstract][Full Text] [Related]
3. The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models.
Naia L; Ly P; Mota SI; Lopes C; Maranga C; Coelho P; Gershoni-Emek N; Ankarcrona M; Geva M; Hayden MR; Rego AC
Neurotherapeutics; 2021 Apr; 18(2):1017-1038. PubMed ID: 33797036
[TBL] [Abstract][Full Text] [Related]
4. Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.
Eddings CR; Arbez N; Akimov S; Geva M; Hayden MR; Ross CA
Neurobiol Dis; 2019 Sep; 129():118-129. PubMed ID: 31108174
[TBL] [Abstract][Full Text] [Related]
5. Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.
Ryskamp D; Wu L; Wu J; Kim D; Rammes G; Geva M; Hayden M; Bezprozvanny I
Neurobiol Dis; 2019 Apr; 124():489-504. PubMed ID: 30594810
[TBL] [Abstract][Full Text] [Related]
6. Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders.
Maurice T
Expert Opin Drug Discov; 2021 Apr; 16(4):373-389. PubMed ID: 33070647
[No Abstract] [Full Text] [Related]
7. Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin.
Lajoie P; Snapp EL
J Cell Sci; 2011 Oct; 124(Pt 19):3332-43. PubMed ID: 21896647
[TBL] [Abstract][Full Text] [Related]
8. Pridopidine rescues BDNF/TrkB trafficking dynamics and synapse homeostasis in a Huntington disease brain-on-a-chip model.
Lenoir S; Lahaye RA; Vitet H; Scaramuzzino C; Virlogeux A; Capellano L; Genoux A; Gershoni-Emek N; Geva M; Hayden MR; Saudou F
Neurobiol Dis; 2022 Oct; 173():105857. PubMed ID: 36075537
[TBL] [Abstract][Full Text] [Related]
9. Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [
Grachev ID; Meyer PM; Becker GA; Bronzel M; Marsteller D; Pastino G; Voges O; Rabinovich L; Knebel H; Zientek F; Rullmann M; Sattler B; Patt M; Gerhards T; Strauss M; Kluge A; Brust P; Savola JM; Gordon MF; Geva M; Hesse S; Barthel H; Hayden MR; Sabri O
Eur J Nucl Med Mol Imaging; 2021 Apr; 48(4):1103-1115. PubMed ID: 32995944
[TBL] [Abstract][Full Text] [Related]
10. Profile of pridopidine and its potential in the treatment of Huntington disease: the evidence to date.
Squitieri F; de Yebenes JG
Drug Des Devel Ther; 2015; 9():5827-33. PubMed ID: 26604684
[TBL] [Abstract][Full Text] [Related]
11. Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish.
Crouzier L; Denus M; Richard EM; Tavernier A; Diez C; Cubedo N; Maurice T; Delprat B
Int J Mol Sci; 2021 Oct; 22(20):. PubMed ID: 34681705
[TBL] [Abstract][Full Text] [Related]
12. Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.
Kusko R; Dreymann J; Ross J; Cha Y; Escalante-Chong R; Garcia-Miralles M; Tan LJ; Burczynski ME; Zeskind B; Laifenfeld D; Pouladi M; Geva M; Grossman I; Hayden MR
Mol Neurodegener; 2018 May; 13(1):25. PubMed ID: 29783994
[TBL] [Abstract][Full Text] [Related]
13. Mutational Analysis of Sigma-1 Receptor's Role in Synaptic Stability.
Ryskamp DA; Zhemkov V; Bezprozvanny I
Front Neurosci; 2019; 13():1012. PubMed ID: 31607852
[TBL] [Abstract][Full Text] [Related]
14. Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease.
Zhou X; Li G; Kaplan A; Gaschler MM; Zhang X; Hou Z; Jiang M; Zott R; Cremers S; Stockwell BR; Duan W
Hum Mol Genet; 2018 May; 27(9):1545-1555. PubMed ID: 29462355
[TBL] [Abstract][Full Text] [Related]
15. Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells.
Chiang MC; Cheng YC; Nicol CJ; Lin KH; Yen CH; Chen SJ; Huang RN
Exp Cell Res; 2015 Nov; 338(2):183-93. PubMed ID: 26362846
[TBL] [Abstract][Full Text] [Related]
16. Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.
Francardo V; Geva M; Bez F; Denis Q; Steiner L; Hayden MR; Cenci MA
Neurotherapeutics; 2019 Apr; 16(2):465-479. PubMed ID: 30756361
[TBL] [Abstract][Full Text] [Related]
17. Effects of the Dopamine Stabilizer, Pridopidine, on Basal and Phencyclidine-Induced Locomotion: Role of Dopamine D2 and Sigma-1 Receptors.
Sahlholm K; Valle-Leon M; Taura J; Fernandez-Duenas V; Ciruela F
CNS Neurol Disord Drug Targets; 2018; 17(7):522-527. PubMed ID: 29952269
[TBL] [Abstract][Full Text] [Related]
18. Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma.
Geva M; Gershoni-Emek N; Naia L; Ly P; Mota S; Rego AC; Hayden MR; Levin LA
Sci Rep; 2021 Nov; 11(1):21975. PubMed ID: 34753986
[TBL] [Abstract][Full Text] [Related]
19. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.
Peviani M; Salvaneschi E; Bontempi L; Petese A; Manzo A; Rossi D; Salmona M; Collina S; Bigini P; Curti D
Neurobiol Dis; 2014 Feb; 62():218-32. PubMed ID: 24141020
[TBL] [Abstract][Full Text] [Related]
20. The Sigma-1 receptor is an ER-localized type II membrane protein.
Sharma N; Patel C; Shenkman M; Kessel A; Ben-Tal N; Lederkremer GZ
J Biol Chem; 2021 Nov; 297(5):101299. PubMed ID: 34648767
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
