These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

124 related articles for article (PubMed ID: 33872946)

  • 1. Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase.
    Takahashi M; Hirota I; Nakano T; Kotani T; Takani D; Shiratori K; Choi Y; Haba M; Hosokawa M
    Drug Metab Pharmacokinet; 2021 Jun; 38():100391. PubMed ID: 33872946
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1.
    Takahashi M; Ogawa T; Kashiwagi H; Fukushima F; Yoshitsugu M; Haba M; Hosokawa M
    Bioorg Med Chem Lett; 2018 Apr; 28(6):997-1000. PubMed ID: 29503023
    [TBL] [Abstract][Full Text] [Related]  

  • 3. [Evaluation of the Oral Absorption of Ester-type Prodrugs].
    Ohura K
    Yakugaku Zasshi; 2020; 140(3):369-376. PubMed ID: 32115554
    [TBL] [Abstract][Full Text] [Related]  

  • 4. [Hydrolysis by carboxylesterase and disposition of prodrug with ester moiety].
    Imai T
    Yakugaku Zasshi; 2007 Apr; 127(4):611-9. PubMed ID: 17409690
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters.
    Takahashi M; Takani D; Haba M; Hosokawa M
    Chirality; 2020 Jan; 32(1):73-80. PubMed ID: 31693270
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases.
    Mizoi K; Takahashi M; Sakai S; Ogihara T; Haba M; Hosokawa M
    Xenobiotica; 2020 Mar; 50(3):261-269. PubMed ID: 31173561
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism.
    Ross MK; Crow JA
    J Biochem Mol Toxicol; 2007; 21(4):187-96. PubMed ID: 17936933
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine.
    Ohura K; Nishiyama H; Saco S; Kurokawa K; Imai T
    Drug Metab Dispos; 2016 Dec; 44(12):1890-1898. PubMed ID: 27638507
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity.
    Ohura K; Sakamoto H; Ninomiya S; Imai T
    Drug Metab Dispos; 2010 Feb; 38(2):323-31. PubMed ID: 19923255
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase.
    Takahashi M; Uehara T; Nonaka M; Minagawa Y; Yamazaki R; Haba M; Hosokawa M
    Eur J Pharm Sci; 2019 Apr; 132():125-131. PubMed ID: 30878380
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.
    Yang D; Pearce RE; Wang X; Gaedigk R; Wan YJ; Yan B
    Biochem Pharmacol; 2009 Jan; 77(2):238-47. PubMed ID: 18983829
    [TBL] [Abstract][Full Text] [Related]  

  • 12. [Design and development of fluorescent probe substrates for carboxylesterase 1 using BODIPY as the basic fluorophore].
    Ding LL; Tian ZH; Hou J; Weng ZM; Cui JN; Yang L; Ge GB
    Yao Xue Xue Bao; 2017 Jan; 52(1):58-65. PubMed ID: 29911769
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2.
    Yang J; Shi D; Yang D; Song X; Yan B
    Mol Pharmacol; 2007 Sep; 72(3):686-94. PubMed ID: 17537833
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases.
    Mizoi K; Takahashi M; Haba M; Hosokawa M
    Bioorg Med Chem Lett; 2016 Feb; 26(3):921-923. PubMed ID: 26750256
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors.
    Thomsen R; Rasmussen HB; Linnet K;
    Drug Metab Dispos; 2014 Jan; 42(1):126-33. PubMed ID: 24141856
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The role of human carboxylesterases in drug metabolism: have we overlooked their importance?
    Laizure SC; Herring V; Hu Z; Witbrodt K; Parker RB
    Pharmacotherapy; 2013 Feb; 33(2):210-22. PubMed ID: 23386599
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein.
    Ohura K; Nakada Y; Kotani S; Imai T
    J Pharm Sci; 2015 Sep; 104(9):3076-83. PubMed ID: 25953731
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis.
    Laizure SC; Parker RB; Herring VL; Hu ZY
    Drug Metab Dispos; 2014 Feb; 42(2):201-6. PubMed ID: 24212379
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel.
    Shi D; Yang J; Yang D; LeCluyse EL; Black C; You L; Akhlaghi F; Yan B
    J Pharmacol Exp Ther; 2006 Dec; 319(3):1477-84. PubMed ID: 16966469
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro hydrolysis and transesterification of CDP323, an α4β1/α4β7 integrin antagonist ester prodrug.
    Chanteux H; Rosa M; Delatour C; Prakash C; Smith S; Nicolas JM
    Drug Metab Dispos; 2014 Jan; 42(1):153-61. PubMed ID: 24179032
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.