180 related articles for article (PubMed ID: 33882714)
1. Small-molecule inhibitors of carboxylesterase Notum.
Zhao Y; Jolly S; Benvegnu S; Jones EY; Fish PV
Future Med Chem; 2021 Jun; 13(11):1001-1015. PubMed ID: 33882714
[TBL] [Abstract][Full Text] [Related]
2. Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
Bayle ED; Svensson F; Atkinson BN; Steadman D; Willis NJ; Woodward HL; Whiting P; Vincent JP; Fish PV
J Med Chem; 2021 Apr; 64(8):4289-4311. PubMed ID: 33783220
[TBL] [Abstract][Full Text] [Related]
3. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Willis NJ; Mahy W; Sipthorp J; Zhao Y; Woodward HL; Atkinson BN; Bayle ED; Svensson F; Frew S; Jeganathan F; Monaghan A; Benvegnù S; Jolly S; Vecchia L; Ruza RR; Kjær S; Howell S; Snijders AP; Bictash M; Salinas PC; Vincent JP; Jones EY; Whiting P; Fish PV
J Med Chem; 2022 May; 65(10):7212-7230. PubMed ID: 35536179
[TBL] [Abstract][Full Text] [Related]
4. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
Steadman D; Atkinson BN; Zhao Y; Willis NJ; Frew S; Monaghan A; Patel C; Armstrong E; Costelloe K; Magno L; Bictash M; Jones EY; Fish PV; Svensson F
J Med Chem; 2022 Jan; 65(1):562-578. PubMed ID: 34939789
[TBL] [Abstract][Full Text] [Related]
5. 5-Phenyl-1,3,4-oxadiazol-2(3
Mahy W; Willis NJ; Zhao Y; Woodward HL; Svensson F; Sipthorp J; Vecchia L; Ruza RR; Hillier J; Kjær S; Frew S; Monaghan A; Bictash M; Salinas PC; Whiting P; Vincent JP; Jones EY; Fish PV
J Med Chem; 2020 Nov; 63(21):12942-12956. PubMed ID: 33124429
[TBL] [Abstract][Full Text] [Related]
6. Structural Insights into Notum Covalent Inhibition.
Zhao Y; Svensson F; Steadman D; Frew S; Monaghan A; Bictash M; Moreira T; Chalk R; Lu W; Fish PV; Jones EY
J Med Chem; 2021 Aug; 64(15):11354-11363. PubMed ID: 34292747
[TBL] [Abstract][Full Text] [Related]
7. Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum.
Zhao Y; Ren J; Hillier J; Jones M; Lu W; Jones EY
J Pineal Res; 2020 Mar; 68(2):e12630. PubMed ID: 31876313
[TBL] [Abstract][Full Text] [Related]
8. Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
Mahy W; Patel M; Steadman D; Woodward HL; Atkinson BN; Svensson F; Willis NJ; Flint A; Papatheodorou D; Zhao Y; Vecchia L; Ruza RR; Hillier J; Frew S; Monaghan A; Costa A; Bictash M; Walter MW; Jones EY; Fish PV
J Med Chem; 2020 Sep; 63(17):9464-9483. PubMed ID: 32787107
[TBL] [Abstract][Full Text] [Related]
9. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase.
Tarver JE; Pabba PK; Barbosa J; Han Q; Gardyan MW; Brommage R; Thompson AY; Schmidt JM; Wilson AGE; He W; Lombardo VK; Carson KG
Bioorg Med Chem Lett; 2016 Mar; 26(6):1525-1528. PubMed ID: 26897593
[TBL] [Abstract][Full Text] [Related]
10. Notum deacylates Wnt proteins to suppress signalling activity.
Kakugawa S; Langton PF; Zebisch M; Howell S; Chang TH; Liu Y; Feizi T; Bineva G; O'Reilly N; Snijders AP; Jones EY; Vincent JP
Nature; 2015 Mar; 519(7542):187-192. PubMed ID: 25731175
[TBL] [Abstract][Full Text] [Related]
11. 4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase.
Han Q; Pabba PK; Barbosa J; Mabon R; Healy JP; Gardyan MW; Terranova KM; Brommage R; Thompson AY; Schmidt JM; Wilson AG; Xu X; Tarver JE; Carson KG
Bioorg Med Chem Lett; 2016 Feb; 26(4):1184-7. PubMed ID: 26821819
[TBL] [Abstract][Full Text] [Related]
12. Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Atkinson BN; Steadman D; Zhao Y; Sipthorp J; Vecchia L; Ruza RR; Jeganathan F; Lines G; Frew S; Monaghan A; Kjær S; Bictash M; Jones EY; Fish PV
Medchemcomm; 2019 Aug; 10(8):1361-1369. PubMed ID: 31534655
[TBL] [Abstract][Full Text] [Related]
13. Caffeine inhibits Notum activity by binding at the catalytic pocket.
Zhao Y; Ren J; Hillier J; Lu W; Jones EY
Commun Biol; 2020 Oct; 3(1):555. PubMed ID: 33033363
[TBL] [Abstract][Full Text] [Related]
14. Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes.
Wassermann AM; Kutchukian PS; Lounkine E; Luethi T; Hamon J; Bocker MT; Malik HA; Cowan-Jacob SW; Glick M
J Med Chem; 2013 Nov; 56(21):8879-91. PubMed ID: 24117015
[TBL] [Abstract][Full Text] [Related]
15. Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Atkinson BN; Willis NJ; Zhao Y; Patel C; Frew S; Costelloe K; Magno L; Svensson F; Jones EY; Fish PV
Eur J Med Chem; 2023 May; 251():115132. PubMed ID: 36934521
[TBL] [Abstract][Full Text] [Related]
16. Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Gong H; Niu Q; Zhou Y; Wang YX; Xu XF; Hou KZ
Bioengineered; 2021 Dec; 12(1):5241-5252. PubMed ID: 34402722
[TBL] [Abstract][Full Text] [Related]
17. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.
Suciu RM; Cognetta AB; Potter ZE; Cravatt BF
ACS Med Chem Lett; 2018 Jun; 9(6):563-568. PubMed ID: 29937983
[TBL] [Abstract][Full Text] [Related]
18. Osteoblast-derived NOTUM reduces cortical bone mass in mice and the
Movérare-Skrtic S; Nilsson KH; Henning P; Funck-Brentano T; Nethander M; Rivadeneira F; Coletto Nunes G; Koskela A; Tuukkanen J; Tuckermann J; Perret C; Souza PPC; Lerner UH; Ohlsson C
FASEB J; 2019 Oct; 33(10):11163-11179. PubMed ID: 31307226
[TBL] [Abstract][Full Text] [Related]
19. Structural Analysis and Development of Notum Fragment Screening Hits.
Zhao Y; Mahy W; Willis NJ; Woodward HL; Steadman D; Bayle ED; Atkinson BN; Sipthorp J; Vecchia L; Ruza RR; Harlos K; Jeganathan F; Constantinou S; Costa A; Kjær S; Bictash M; Salinas PC; Whiting P; Vincent JP; Fish PV; Jones EY
ACS Chem Neurosci; 2022 Jul; 13(13):2060-2077. PubMed ID: 35731924
[TBL] [Abstract][Full Text] [Related]
20.
Tian Y; Wang X; Cramer Z; Rhoades J; Estep KN; Ma X; Adams-Tzivelekidis S; Katona BW; Johnson FB; Yu Z; Blanco MA; Lengner CJ; Li N
Gut; 2023 Nov; 72(12):2294-2306. PubMed ID: 37591698
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]