BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

275 related articles for article (PubMed ID: 33891006)

  • 1. ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
    Lin BC; Phung TH; Higgins NR; Greenslade JE; Prado MA; Finley D; Karbowski M; Polster BM; Monteiro MJ
    Hum Mol Genet; 2021 Jun; 30(13):1230-1246. PubMed ID: 33891006
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD.
    Higgins NR; Greenslade JE; Wu JJ; Miranda E; Galliciotti G; Monteiro MJ
    Brain Pathol; 2021 Sep; 31(5):e12948. PubMed ID: 33780087
    [TBL] [Abstract][Full Text] [Related]  

  • 3. ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
    Wu JJ; Cai A; Greenslade JE; Higgins NR; Fan C; Le NTT; Tatman M; Whiteley AM; Prado MA; Dieriks BV; Curtis MA; Shaw CE; Siddique T; Faull RLM; Scotter EL; Finley D; Monteiro MJ
    Proc Natl Acad Sci U S A; 2020 Jun; 117(26):15230-15241. PubMed ID: 32513711
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD.
    Wang S; Tatman M; Monteiro MJ
    Acta Neuropathol Commun; 2020 Oct; 8(1):164. PubMed ID: 33028421
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.
    Strohm L; Hu Z; Suk Y; Rühmkorf A; Sternburg E; Gattringer V; Riemenschneider H; Berutti R; Graf E; Weishaupt JH; Brill MS; Harbauer AB; Dormann D; Dengjel J; Edbauer D; Behrends C
    Life Sci Alliance; 2022 Nov; 5(11):. PubMed ID: 35777956
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Global proteomics of Ubqln2-based murine models of ALS.
    Whiteley AM; Prado MA; de Poot SAH; Paulo JA; Ashton M; Dominguez S; Weber M; Ngu H; Szpyt J; Jedrychowski MP; Easton A; Gygi SP; Kurz T; Monteiro MJ; Brown EJ; Finley D
    J Biol Chem; 2021; 296():100153. PubMed ID: 33277362
    [TBL] [Abstract][Full Text] [Related]  

  • 7. UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD.
    Lin BC; Higgins NR; Phung TH; Monteiro MJ
    FEBS J; 2022 Oct; 289(20):6132-6153. PubMed ID: 34273246
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.
    Le NT; Chang L; Kovlyagina I; Georgiou P; Safren N; Braunstein KE; Kvarta MD; Van Dyke AM; LeGates TA; Philips T; Morrison BM; Thompson SM; Puche AC; Gould TD; Rothstein JD; Wong PC; Monteiro MJ
    Proc Natl Acad Sci U S A; 2016 Nov; 113(47):E7580-E7589. PubMed ID: 27834214
    [TBL] [Abstract][Full Text] [Related]  

  • 9. UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.
    Zhang K; Wang A; Zhong K; Qi S; Wei C; Shu X; Tu WY; Xu W; Xia C; Xiao Y; Chen A; Bai L; Zhang J; Luo B; Wang W; Shen C
    Neuron; 2021 Jun; 109(12):1949-1962.e6. PubMed ID: 33991504
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity.
    Sharkey LM; Sandoval-Pistorius SS; Moore SJ; Gerson JE; Komlo R; Fischer S; Negron-Rios KY; Crowley EV; Padron F; Patel R; Murphy GG; Paulson HL
    Neurobiol Dis; 2020 Sep; 143():105016. PubMed ID: 32653673
    [TBL] [Abstract][Full Text] [Related]  

  • 11. UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.
    Phung TH; Tatman M; Monteiro MJ
    Biochim Biophys Acta Gen Subj; 2023 Feb; 1867(2):130284. PubMed ID: 36423739
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1.
    Peng G; Gu A; Niu H; Chen L; Chen Y; Zhou M; Zhang Y; Liu J; Cai L; Liang D; Liu X; Liu M
    CNS Neurosci Ther; 2022 Jan; 28(1):105-115. PubMed ID: 34750982
    [TBL] [Abstract][Full Text] [Related]  

  • 13. UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture.
    Ma Q; Xin J; Peng Q; Li N; Sun S; Hou H; Ma G; Wang N; Zhang L; Tam KY; Dussmann H; Prehn JH; Wang H; Ying Z
    EMBO Rep; 2023 Sep; 24(9):e55859. PubMed ID: 37501540
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia.
    Nementzik LR; Thumbadoo KM; Murray HC; Gordon D; Yang S; Blair IP; Turner C; Faull RLM; Curtis MA; McLean C; Nicholson GA; Swanson MEV; Scotter EL
    Brain Pathol; 2024 May; 34(3):e13230. PubMed ID: 38115557
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia.
    Renaud L; Picher-Martel V; Codron P; Julien JP
    Acta Neuropathol Commun; 2019 Jul; 7(1):103. PubMed ID: 31319884
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2.
    Kim SH; Nichols KD; Anderson EN; Liu Y; Ramesh N; Jia W; Kuerbis CJ; Scalf M; Smith LM; Pandey UB; Tibbetts RS
    Elife; 2023 Apr; 12():. PubMed ID: 37039476
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity.
    Safren N; Dao TP; Mohan HM; Huang C; Trotter B; Castañeda CA; Paulson H; Barmada S; Sharkey LM
    Sci Rep; 2024 Mar; 14(1):6049. PubMed ID: 38472280
    [TBL] [Abstract][Full Text] [Related]  

  • 18. ALS-linked mutations impair UBQLN2 stress-induced biomolecular condensate assembly in cells.
    Riley JF; Fioramonti PJ; Rusnock AK; Hehnly H; Castañeda CA
    J Neurochem; 2021 Oct; 159(1):145-155. PubMed ID: 34129687
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis.
    Osaka M; Ito D; Yagi T; Nihei Y; Suzuki N
    Hum Mol Genet; 2015 Mar; 24(6):1617-29. PubMed ID: 25398946
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia.
    Gellera C; Tiloca C; Del Bo R; Corrado L; Pensato V; Agostini J; Cereda C; Ratti A; Castellotti B; Corti S; Bagarotti A; Cagnin A; Milani P; Gabelli C; Riboldi G; Mazzini L; Sorarù G; D'Alfonso S; Taroni F; Comi GP; Ticozzi N; Silani V;
    J Neurol Neurosurg Psychiatry; 2013 Feb; 84(2):183-7. PubMed ID: 23138764
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.