165 related articles for article (PubMed ID: 33910001)
1. Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Kim S; Yoon I; Son J; Park J; Kim K; Lee JH; Park SY; Kang BS; Han JM; Hwang KY; Kim S
Cell Rep; 2021 Apr; 35(4):109031. PubMed ID: 33910001
[TBL] [Abstract][Full Text] [Related]
2. O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.
Kim K; Yoo HC; Kim BG; Kim S; Sung Y; Yoon I; Yu YC; Park SJ; Kim JH; Myung K; Hwang KY; Kim S; Han JM
Nat Commun; 2022 May; 13(1):2904. PubMed ID: 35614056
[TBL] [Abstract][Full Text] [Related]
3. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
Lee M; Kim JH; Yoon I; Lee C; Fallahi Sichani M; Kang JS; Kang J; Guo M; Lee KY; Han G; Kim S; Han JM
Proc Natl Acad Sci U S A; 2018 Jun; 115(23):E5279-E5288. PubMed ID: 29784813
[TBL] [Abstract][Full Text] [Related]
4. Developing a comprehensive solution aimed to disrupt LARS1/RagD protein-protein interaction.
Raevsky A; Kovalenko O; Bulgakov E; Sharifi M; Volochnyuk D; Tukalo M
J Biomol Struct Dyn; 2024; 42(2):747-758. PubMed ID: 36995308
[TBL] [Abstract][Full Text] [Related]
5. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.
Kim JH; Lee C; Lee M; Wang H; Kim K; Park SJ; Yoon I; Jang J; Zhao H; Kim HK; Kwon NH; Jeong SJ; Yoo HC; Kim JH; Yang JS; Lee MY; Lee CW; Yun J; Oh SJ; Kang JS; Martinis SA; Hwang KY; Guo M; Han G; Han JM; Kim S
Nat Commun; 2017 Sep; 8(1):732. PubMed ID: 28963468
[TBL] [Abstract][Full Text] [Related]
6. Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.
Yoon I; Nam M; Kim HK; Moon HS; Kim S; Jang J; Song JA; Jeong SJ; Kim SB; Cho S; Kim Y; Lee J; Yang WS; Yoo HC; Kim K; Kim MS; Yang A; Cho K; Park HS; Hwang GS; Hwang KY; Han JM; Kim JH; Kim S
Science; 2020 Jan; 367(6474):205-210. PubMed ID: 31780625
[TBL] [Abstract][Full Text] [Related]
7. Protocol for improving diffraction quality of leucyl-tRNA synthetase 1 with methylation and post-crystallization soaking and cooling in cryoprotectants.
Kim S; Yoon I; Kim S; Hwang KY
STAR Protoc; 2021 Sep; 2(3):100642. PubMed ID: 34258600
[TBL] [Abstract][Full Text] [Related]
8. Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.
Choi H; Son JB; Kang J; Kwon J; Kim JH; Jung M; Kim SK; Kim S; Mun JY
Biochem Biophys Res Commun; 2017 Nov; 493(2):1129-1135. PubMed ID: 28882589
[TBL] [Abstract][Full Text] [Related]
9. Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction.
Kim JH; Jung K; Lee C; Song D; Kim K; Yoo HC; Park SJ; Kang JS; Lee KR; Kim S; Han JM; Han G
Bioorg Chem; 2021 Jul; 112():104907. PubMed ID: 33979735
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Yoon S; Kim SE; Kim JH; Yoon I; Tran PT; Ann J; Kim C; Byun WS; Lee S; Kim S; Lee J; Lee J
Bioorg Med Chem; 2019 Mar; 27(6):1099-1109. PubMed ID: 30755350
[TBL] [Abstract][Full Text] [Related]
11. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
Han JM; Jeong SJ; Park MC; Kim G; Kwon NH; Kim HK; Ha SH; Ryu SH; Kim S
Cell; 2012 Apr; 149(2):410-24. PubMed ID: 22424946
[TBL] [Abstract][Full Text] [Related]
12. Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling.
Yoon MS; Son K; Arauz E; Han JM; Kim S; Chen J
Cell Rep; 2016 Aug; 16(6):1510-1517. PubMed ID: 27477288
[TBL] [Abstract][Full Text] [Related]
13. Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells.
Bae JH; Kim JH
Biochem Biophys Res Commun; 2021 Sep; 571():159-166. PubMed ID: 34325132
[TBL] [Abstract][Full Text] [Related]
14. PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
D'Hulst G; Soro-Arnaiz I; Masschelein E; Veys K; Fitzgerald G; Smeuninx B; Kim S; Deldicque L; Blaauw B; Carmeliet P; Breen L; Koivunen P; Zhao SM; De Bock K
Nat Commun; 2020 Jan; 11(1):174. PubMed ID: 31924757
[TBL] [Abstract][Full Text] [Related]
15. Leucyl-tRNA synthetase: double duty in amino acid sensing.
Durán RV; Hall MN
Cell Res; 2012 Aug; 22(8):1207-9. PubMed ID: 22525334
[TBL] [Abstract][Full Text] [Related]
16. Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S; Zuo D; Kim JH; Yoon I; Ann J; Kim SE; Cho D; Kim WK; Lee S; Lee J; Kim S; Lee J
Bioorg Med Chem; 2018 Aug; 26(14):4073-4079. PubMed ID: 30041947
[TBL] [Abstract][Full Text] [Related]
17. Combination of the LARS1 Inhibitor, BC-LI-0186 with a MEK1/2 Inhibitor Enhances the Anti-Tumor Effect in Non-Small Cell Lung Cancer.
Lee SH; Kim EY; Han JM; Han G; Chang YS
Cancer Res Treat; 2023 Jul; 55(3):851-864. PubMed ID: 36960627
[TBL] [Abstract][Full Text] [Related]
18. Leucyl-tRNA synthetase controls TORC1 via the EGO complex.
Bonfils G; Jaquenoud M; Bontron S; Ostrowicz C; Ungermann C; De Virgilio C
Mol Cell; 2012 Apr; 46(1):105-10. PubMed ID: 22424774
[TBL] [Abstract][Full Text] [Related]
19. Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase.
Palencia A; Crépin T; Vu MT; Lincecum TL; Martinis SA; Cusack S
Nat Struct Mol Biol; 2012 Jun; 19(7):677-84. PubMed ID: 22683997
[TBL] [Abstract][Full Text] [Related]
20. Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration.
Son K; You JS; Yoon MS; Dai C; Kim JH; Khanna N; Banerjee A; Martinis SA; Han G; Han JM; Kim S; Chen J
J Clin Invest; 2019 Apr; 129(5):2088-2093. PubMed ID: 30985292
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
