BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

151 related articles for article (PubMed ID: 33920961)

  • 1. Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors.
    Medeiros AR; Ferreira LLG; de Souza ML; de Oliveira Rezende Junior C; Espinoza-Chávez RM; Dias LC; Andricopulo AD
    Biomolecules; 2021 Apr; 11(4):. PubMed ID: 33920961
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors.
    Pauli I; Ferreira LG; de Souza ML; Oliva G; Ferreira RS; Dessoy MA; Slafer BW; Dias LC; Andricopulo AD
    Future Med Chem; 2017 May; 9(7):641-657. PubMed ID: 28509592
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular description of α-keto-based inhibitors of cruzain with activity against Chagas disease combining 3D-QSAR studies and molecular dynamics.
    Saraiva ÁPB; Miranda RM; Valente RPP; Araújo JO; Souza RNB; Costa CHS; Oliveira ARS; Almeida MO; Figueiredo AF; Ferreira JEV; Alves CN; Honorio KM
    Chem Biol Drug Des; 2018 Aug; 92(2):1475-1487. PubMed ID: 29682904
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Development of a pharmacophore for cruzain using oxadiazoles as virtual molecular probes: quantitative structure-activity relationship studies.
    de Souza AS; de Oliveira MT; Andricopulo AD
    J Comput Aided Mol Des; 2017 Sep; 31(9):801-816. PubMed ID: 28795372
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Highly predictive hologram QSAR models of nitrile-containing cruzain inhibitors.
    Silva DG; Rocha JR; Sartori GR; Montanari CA
    J Biomol Struct Dyn; 2017 Nov; 35(15):3232-3249. PubMed ID: 27809673
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quantitative structure-activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: molecular modeling, CoMFA and CoMSIA studies.
    Trossini GH; Guido RV; Oliva G; Ferreira EI; Andricopulo AD
    J Mol Graph Model; 2009 Aug; 28(1):3-11. PubMed ID: 19376735
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 2D QSAR and similarity studies on cruzain inhibitors aimed at improving selectivity over cathepsin L.
    Freitas RF; Oprea TI; Montanari CA
    Bioorg Med Chem; 2008 Jan; 16(2):838-53. PubMed ID: 17996450
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular Docking Studies Applied to a Dataset of Cruzain Inhibitors.
    da Silva-Junior EF; Barcellos Franca PH; Ribeiro FF; Bezerra Mendonca-Junior FJ; Scotti L; Scotti MT; de Aquino TM; de Araujo-Junior JX
    Curr Comput Aided Drug Des; 2018; 14(1):68-78. PubMed ID: 28523999
    [TBL] [Abstract][Full Text] [Related]  

  • 9. CoMFA and HQSAR of acylhydrazide cruzain inhibitors.
    Rodrigues CR; Flaherty TM; Springer C; McKerrow JH; Cohen FE
    Bioorg Med Chem Lett; 2002 Jun; 12(11):1537-41. PubMed ID: 12031337
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular docking and 3D-quantitative structure activity relationship analyses of peptidyl vinyl sulfones: Plasmodium Falciparum cysteine proteases inhibitors.
    Teixeira C; Gomes JR; Couesnon T; Gomes P
    J Comput Aided Mol Des; 2011 Aug; 25(8):763-75. PubMed ID: 21786172
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain.
    Huang L; Brinen LS; Ellman JA
    Bioorg Med Chem; 2003 Jan; 11(1):21-9. PubMed ID: 12467703
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach.
    de Souza ML; de Oliveira Rezende Junior C; Ferreira RS; Espinoza Chávez RM; Ferreira LLG; Slafer BW; Magalhães LG; Krogh R; Oliva G; Cruz FC; Dias LC; Andricopulo AD
    J Chem Inf Model; 2020 Feb; 60(2):1028-1041. PubMed ID: 31765144
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.
    Choe Y; Brinen LS; Price MS; Engel JC; Lange M; Grisostomi C; Weston SG; Pallai PV; Cheng H; Hardy LW; Hartsough DS; McMakin M; Tilton RF; Baldino CM; Craik CS
    Bioorg Med Chem; 2005 Mar; 13(6):2141-56. PubMed ID: 15727867
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay.
    Wiggers HJ; Rocha JR; Fernandes WB; Sesti-Costa R; Carneiro ZA; Cheleski J; da Silva AB; Juliano L; Cezari MH; Silva JS; McKerrow JH; Montanari CA
    PLoS Negl Trop Dis; 2013; 7(8):e2370. PubMed ID: 23991231
    [TBL] [Abstract][Full Text] [Related]  

  • 15. CoMFA, CoMSIA, Topomer CoMFA, HQSAR, molecular docking and molecular dynamics simulations study of triazine morpholino derivatives as mTOR inhibitors for the treatment of breast cancer.
    Chhatbar DM; Chaube UJ; Vyas VK; Bhatt HG
    Comput Biol Chem; 2019 Jun; 80():351-363. PubMed ID: 31085426
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural modification of 4, 5-dihydro-[1, 2, 4] triazolo [4, 3-f] pteridine derivatives as BRD4 inhibitors using 2D/3D-QSAR and molecular docking analysis.
    Tong JB; Luo D; Feng Y; Bian S; Zhang X; Wang TH
    Mol Divers; 2021 Aug; 25(3):1855-1872. PubMed ID: 33392965
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cruzain structures: apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design.
    Barbosa da Silva E; Dall E; Briza P; Brandstetter H; Ferreira RS
    Acta Crystallogr F Struct Biol Commun; 2019 Jun; 75(Pt 6):419-427. PubMed ID: 31204688
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi.
    Guido RV; Trossini GH; Castilho MS; Oliva G; Ferreira EI; Andricopulo AD
    J Enzyme Inhib Med Chem; 2008 Dec; 23(6):964-73. PubMed ID: 19005945
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Aryl ureas represent a new class of anti-trypanosomal agents.
    Du X; Hansell E; Engel JC; Caffrey CR; Cohen FE; McKerrow JH
    Chem Biol; 2000 Sep; 7(9):733-42. PubMed ID: 10980453
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study.
    Vital DG; Damasceno FS; Rapado LN; Silber AM; Vilella FS; Ferreira RS; Maltarollo VG; Trossini GH
    J Biomol Struct Dyn; 2017 May; 35(6):1244-1259. PubMed ID: 27064715
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.