146 related articles for article (PubMed ID: 33921487)
1. Pharmacokinetic Characterization of LW6, a Novel Hypoxia-Inducible Factor-1α (HIF-1α) Inhibitor in Mice.
Lee JY; Lee K; Lee K; Kang JS; Kim MJ; Yoo DG; Kim JA; Shin EJ; Oh SJ
Molecules; 2021 Apr; 26(8):. PubMed ID: 33921487
[TBL] [Abstract][Full Text] [Related]
2. Metabolite Profiling and Characterization of LW6, a Novel HIF-1α Inhibitor, as an Antitumor Drug Candidate in Mice.
Lee K; Lee JY; Lee K; Jung CR; Kim MJ; Kim JA; Yoo DG; Shin EJ; Oh SJ
Molecules; 2021 Mar; 26(7):. PubMed ID: 33808438
[TBL] [Abstract][Full Text] [Related]
3. LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line.
Lee K; Kang JE; Park SK; Jin Y; Chung KS; Kim HM; Lee K; Kang MR; Lee MK; Song KB; Yang EG; Lee JJ; Won M
Biochem Pharmacol; 2010 Oct; 80(7):982-9. PubMed ID: 20599784
[TBL] [Abstract][Full Text] [Related]
4. HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1.
Kim BS; Lee K; Jung HJ; Bhattarai D; Kwon HJ
Biochem Biophys Res Commun; 2015 Feb; 458(1):14-20. PubMed ID: 25603055
[TBL] [Abstract][Full Text] [Related]
5. Chemical biology approach for the development of hypoxia inducible factor (HIF) inhibitor LW6 as a potential anticancer agent.
Naik R; Han S; Lee K
Arch Pharm Res; 2015 Sep; 38(9):1563-74. PubMed ID: 26310207
[TBL] [Abstract][Full Text] [Related]
6. LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells.
Sato M; Hirose K; Kashiwakura I; Aoki M; Kawaguchi H; Hatayama Y; Akimoto H; Narita Y; Takai Y
Mol Med Rep; 2015 Sep; 12(3):3462-3468. PubMed ID: 26017562
[TBL] [Abstract][Full Text] [Related]
7. The hypoxia-inducible factor 1 inhibitor LW6 mediates the HIF-1α/PD-L1 axis and suppresses tumor growth of hepatocellular carcinoma in vitro and in vivo.
Xu H; Chen Y; Li Z; Zhang H; Liu J; Han J
Eur J Pharmacol; 2022 Sep; 930():175154. PubMed ID: 35868447
[TBL] [Abstract][Full Text] [Related]
8. Discovery of LW6 as a new potent inhibitor of breast cancer resistance protein.
Song JG; Lee YS; Park JA; Lee EH; Lim SJ; Yang SJ; Zhao M; Lee K; Han HK
Cancer Chemother Pharmacol; 2016 Oct; 78(4):735-44. PubMed ID: 27520631
[TBL] [Abstract][Full Text] [Related]
9. The combination therapy of HIF1α inhibitor LW6 and cisplatin plays an effective role on anti-tumor function in A549 cells.
Mai L; Luo M; Wu JJ; Yang JH; Hong LY
Neoplasma; 2019 Sep; 66(5):776-784. PubMed ID: 31169018
[TBL] [Abstract][Full Text] [Related]
10. Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors.
Xia Y; Duan Q; Zhao BH; Li DF; Hou RB
Med Chem; 2016; 12(4):338-46. PubMed ID: 26548744
[TBL] [Abstract][Full Text] [Related]
11. A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration.
Ban HS; Xu X; Jang K; Kim I; Kim BK; Lee K; Won M
PLoS One; 2016; 11(9):e0162568. PubMed ID: 27611801
[TBL] [Abstract][Full Text] [Related]
12. The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth.
Ban HS; Kim BK; Lee H; Kim HM; Harmalkar D; Nam M; Park SK; Lee K; Park JT; Kim I; Lee K; Hwang GS; Won M
Cell Death Dis; 2017 Jun; 8(6):e2843. PubMed ID: 28569777
[TBL] [Abstract][Full Text] [Related]
13. The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation.
Kim I; Kim M; Park MK; Naik R; Park JH; Kim BK; Choi Y; Chang KY; Won M; Ban HS; Lee K
Exp Mol Med; 2020 Nov; 52(11):1845-1856. PubMed ID: 33235318
[TBL] [Abstract][Full Text] [Related]
14. In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species.
Venkatesh PR; Goh E; Zeng P; New LS; Xin L; Pasha MK; Sangthongpitag K; Yeo P; Kantharaj E
Biol Pharm Bull; 2007 May; 30(5):1021-4. PubMed ID: 17473456
[TBL] [Abstract][Full Text] [Related]
15. Participation of HIFs in the regulation of Sertoli cell lactate production.
Galardo MN; Gorga A; Merlo JP; Regueira M; Pellizzari EH; Cigorraga SB; Riera MF; Meroni SB
Biochimie; 2017 Jan; 132():9-18. PubMed ID: 27750035
[TBL] [Abstract][Full Text] [Related]
16. A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway.
Won MS; Im N; Park S; Boovanahalli SK; Jin Y; Jin X; Chung KS; Kang M; Lee K; Park SK; Kim HM; Kwon BM; Lee JJ; Lee K
Biochem Biophys Res Commun; 2009 Jul; 385(1):16-21. PubMed ID: 19433063
[TBL] [Abstract][Full Text] [Related]
17. Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound.
Park K; Lee HE; Lee SH; Lee D; Lee T; Lee YM
Oncotarget; 2017 Jan; 8(5):7801-7813. PubMed ID: 27999195
[TBL] [Abstract][Full Text] [Related]
18. Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1alpha inhibitors.
Shimizu K; Maruyama M; Yasui Y; Minegishi H; Ban HS; Nakamura H
Bioorg Med Chem Lett; 2010 Feb; 20(4):1453-6. PubMed ID: 20083404
[TBL] [Abstract][Full Text] [Related]
19. [Effects of hypoxia inducible factor-1α on P311 and its influence on the migration of murine epidermal stem cells].
Xu ZD; Li HS; Wang S; He WF; Wu J; Luo GX
Zhonghua Shao Shang Za Zhi; 2017 May; 33(5):287-294. PubMed ID: 28651420
[No Abstract] [Full Text] [Related]
20. Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human.
Su H; Boulton DW; Barros A; Wang L; Cao K; Bonacorsi SJ; Iyer RA; Humphreys WG; Christopher LJ
Drug Metab Dispos; 2012 Jul; 40(7):1345-56. PubMed ID: 22496391
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
