191 related articles for article (PubMed ID: 33927236)
1. Allostery of atypical modulators at oligomeric G protein-coupled receptors.
Shivnaraine RV; Kelly B; Elmslie G; Huang XP; Dong YJ; Seidenberg M; Wells JW; Ellis J
Sci Rep; 2021 Apr; 11(1):9265. PubMed ID: 33927236
[TBL] [Abstract][Full Text] [Related]
2. Allosteric modulation in monomers and oligomers of a G protein-coupled receptor.
Shivnaraine RV; Kelly B; Sankar KS; Redka DS; Han YR; Huang F; Elmslie G; Pinto D; Li Y; Rocheleau JV; Gradinaru CC; Ellis J; Wells JW
Elife; 2016 May; 5():. PubMed ID: 27151542
[TBL] [Abstract][Full Text] [Related]
3. Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors.
Tränkle C; Dittmann A; Schulz U; Weyand O; Buller S; Jöhren K; Heller E; Birdsall NJ; Holzgrabe U; Ellis J; Höltje HD; Mohr K
Mol Pharmacol; 2005 Dec; 68(6):1597-610. PubMed ID: 16157694
[TBL] [Abstract][Full Text] [Related]
4. Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Tränkle C; Weyand O; Voigtländer U; Mynett A; Lazareno S; Birdsall NJ; Mohr K
Mol Pharmacol; 2003 Jul; 64(1):180-90. PubMed ID: 12815174
[TBL] [Abstract][Full Text] [Related]
5. Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites.
Schober DA; Croy CH; Xiao H; Christopoulos A; Felder CC
Mol Pharmacol; 2014 Jul; 86(1):116-23. PubMed ID: 24807966
[TBL] [Abstract][Full Text] [Related]
6. Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.
Miao Y; Goldfeld DA; Moo EV; Sexton PM; Christopoulos A; McCammon JA; Valant C
Proc Natl Acad Sci U S A; 2016 Sep; 113(38):E5675-84. PubMed ID: 27601651
[TBL] [Abstract][Full Text] [Related]
7. Allosteric binding sites on muscarinic acetylcholine receptors.
Wess J
Mol Pharmacol; 2005 Dec; 68(6):1506-9. PubMed ID: 16183853
[TBL] [Abstract][Full Text] [Related]
8. A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor.
Steinfeld T; Mammen M; Smith JA; Wilson RD; Jasper JR
Mol Pharmacol; 2007 Aug; 72(2):291-302. PubMed ID: 17478612
[TBL] [Abstract][Full Text] [Related]
9. Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects.
Valant C; Felder CC; Sexton PM; Christopoulos A
Mol Pharmacol; 2012 Jan; 81(1):41-52. PubMed ID: 21989256
[TBL] [Abstract][Full Text] [Related]
10. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors.
Croy CH; Schober DA; Xiao H; Quets A; Christopoulos A; Felder CC
Mol Pharmacol; 2014 Jul; 86(1):106-15. PubMed ID: 24807965
[TBL] [Abstract][Full Text] [Related]
11. Utility of an "Allosteric Site-Impaired" M
Moo EV; Sexton PM; Christopoulos A; Valant C
Mol Pharmacol; 2018 Nov; 94(5):1298-1309. PubMed ID: 30213802
[TBL] [Abstract][Full Text] [Related]
12. The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.
Avlani VA; McLoughlin DJ; Sexton PM; Christopoulos A
J Pharmacol Exp Ther; 2008 Jun; 325(3):927-34. PubMed ID: 18322151
[TBL] [Abstract][Full Text] [Related]
13. Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor.
Bock A; Bermudez M; Krebs F; Matera C; Chirinda B; Sydow D; Dallanoce C; Holzgrabe U; De Amici M; Lohse MJ; Wolber G; Mohr K
J Biol Chem; 2016 Jul; 291(31):16375-89. PubMed ID: 27298318
[TBL] [Abstract][Full Text] [Related]
14. Application of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein-Coupled Receptors.
Chan WKB; Carlson HA; Traynor JR
Mol Pharmacol; 2023 May; 103(5):274-285. PubMed ID: 36868791
[TBL] [Abstract][Full Text] [Related]
15. Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.
Dror RO; Green HF; Valant C; Borhani DW; Valcourt JR; Pan AC; Arlow DH; Canals M; Lane JR; Rahmani R; Baell JB; Sexton PM; Christopoulos A; Shaw DE
Nature; 2013 Nov; 503(7475):295-9. PubMed ID: 24121438
[TBL] [Abstract][Full Text] [Related]
16. Ligand-Induced Coupling between Oligomers of the M
Li Y; Shivnaraine RV; Huang F; Wells JW; Gradinaru CC
Biophys J; 2018 Sep; 115(5):881-895. PubMed ID: 30131171
[TBL] [Abstract][Full Text] [Related]
17. Heterotropic cooperativity within and between protomers of an oligomeric M(2) muscarinic receptor.
Shivnaraine RV; Huang XP; Seidenberg M; Ellis J; Wells JW
Biochemistry; 2012 Jun; 51(22):4518-40. PubMed ID: 22551249
[TBL] [Abstract][Full Text] [Related]
18. Structure-based discovery of selective positive allosteric modulators of antagonists for the M
Korczynska M; Clark MJ; Valant C; Xu J; Moo EV; Albold S; Weiss DR; Torosyan H; Huang W; Kruse AC; Lyda BR; May LT; Baltos JA; Sexton PM; Kobilka BK; Christopoulos A; Shoichet BK; Sunahara RK
Proc Natl Acad Sci U S A; 2018 Mar; 115(10):E2419-E2428. PubMed ID: 29453275
[TBL] [Abstract][Full Text] [Related]
19. Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation.
Jäger D; Schmalenbach C; Prilla S; Schrobang J; Kebig A; Sennwitz M; Heller E; Tränkle C; Holzgrabe U; Höltje HD; Mohr K
J Biol Chem; 2007 Nov; 282(48):34968-76. PubMed ID: 17890226
[TBL] [Abstract][Full Text] [Related]
20. Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.
Avlani VA; Gregory KJ; Morton CJ; Parker MW; Sexton PM; Christopoulos A
J Biol Chem; 2007 Aug; 282(35):25677-86. PubMed ID: 17591774
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]