These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 33938058)

  • 1. Analysis of electrostatic coupling throughout the laboratory evolution of a designed retroaldolase.
    Coulther TA; Pott M; Zeymer C; Hilvert D; Ondrechen MJ
    Protein Sci; 2021 Aug; 30(8):1617-1627. PubMed ID: 33938058
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evolution of a designed retro-aldolase leads to complete active site remodeling.
    Giger L; Caner S; Obexer R; Kast P; Baker D; Ban N; Hilvert D
    Nat Chem Biol; 2013 Aug; 9(8):494-8. PubMed ID: 23748672
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
    Wymer N; Buchanan LV; Henderson D; Mehta N; Botting CH; Pocivavsek L; Fierke CA; Toone EJ; Naismith JH
    Structure; 2001 Jan; 9(1):1-9. PubMed ID: 11342129
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design.
    Bjelic S; Kipnis Y; Wang L; Pianowski Z; Vorobiev S; Su M; Seetharaman J; Xiao R; Kornhaber G; Hunt JF; Tong L; Hilvert D; Baker D
    J Mol Biol; 2014 Jan; 426(1):256-71. PubMed ID: 24161950
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase.
    Zeymer C; Zschoche R; Hilvert D
    J Am Chem Soc; 2017 Sep; 139(36):12541-12549. PubMed ID: 28783336
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Robust design and optimization of retroaldol enzymes.
    Althoff EA; Wang L; Jiang L; Giger L; Lassila JK; Wang Z; Smith M; Hari S; Kast P; Herschlag D; Hilvert D; Baker D
    Protein Sci; 2012 May; 21(5):717-26. PubMed ID: 22407837
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanism of dihydroneopterin aldolase: functional roles of the conserved active site glutamate and lysine residues.
    Wang Y; Li Y; Yan H
    Biochemistry; 2006 Dec; 45(51):15232-9. PubMed ID: 17176045
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Exploring substrate binding and discrimination in fructose1, 6-bisphosphate and tagatose 1,6-bisphosphate aldolases.
    Zgiby SM; Thomson GJ; Qamar S; Berry A
    Eur J Biochem; 2000 Mar; 267(6):1858-68. PubMed ID: 10712619
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of essential histidine residues in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase: analysis by chemical modification with diethyl pyrocarbonate and site-directed mutagenesis.
    Sheflyan GY; Duewel HS; Chen G; Woodard RW
    Biochemistry; 1999 Oct; 38(43):14320-9. PubMed ID: 10572007
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: electrostatic precollision guidance and transition-state stabilization.
    Koch U; Biasiol G; Brunetti M; Fattori D; Pallaoro M; Steinkühler C
    Biochemistry; 2001 Jan; 40(3):631-40. PubMed ID: 11170379
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series.
    Khersonsky O; Röthlisberger D; Dym O; Albeck S; Jackson CJ; Baker D; Tawfik DS
    J Mol Biol; 2010 Mar; 396(4):1025-42. PubMed ID: 20036254
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting.
    Obexer R; Pott M; Zeymer C; Griffiths AD; Hilvert D
    Protein Eng Des Sel; 2016 Sep; 29(9):355-66. PubMed ID: 27542390
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mutational, kinetic, and NMR studies of the mechanism of E. coli GDP-mannose mannosyl hydrolase, an unusual Nudix enzyme.
    Legler PM; Massiah MA; Mildvan AS
    Biochemistry; 2002 Sep; 41(35):10834-48. PubMed ID: 12196023
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Electrostatic fingerprints of catalytically active amino acids in enzymes.
    Iyengar SM; Barnsley KK; Xu R; Prystupa A; Ondrechen MJ
    Protein Sci; 2022 May; 31(5):e4291. PubMed ID: 35481659
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases.
    Garrabou X; Verez R; Hilvert D
    J Am Chem Soc; 2017 Jan; 139(1):103-106. PubMed ID: 27992715
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutational, kinetic, and NMR studies of the roles of conserved glutamate residues and of lysine-39 in the mechanism of the MutT pyrophosphohydrolase.
    Harris TK; Wu G; Massiah MA; Mildvan AS
    Biochemistry; 2000 Feb; 39(7):1655-74. PubMed ID: 10677214
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.
    Joshi MD; Sidhu G; Nielsen JE; Brayer GD; Withers SG; McIntosh LP
    Biochemistry; 2001 Aug; 40(34):10115-39. PubMed ID: 11513590
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico.
    Broom A; Rakotoharisoa RV; Thompson MC; Zarifi N; Nguyen E; Mukhametzhanov N; Liu L; Fraser JS; Chica RA
    Nat Commun; 2020 Sep; 11(1):4808. PubMed ID: 32968058
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanistic Studies of the
    Mydy LS; Hoppe RW; Hagemann TM; Schwabacher AW; Silvaggi NR
    Biochemistry; 2019 Oct; 58(40):4136-4147. PubMed ID: 31524380
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase.
    Fisher CL; Cabelli DE; Hallewell RA; Beroza P; Lo TP; Getzoff ED; Tainer JA
    Proteins; 1997 Sep; 29(1):103-12. PubMed ID: 9294870
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.