BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 3395138)

  • 1. [The significance of measuring inhibition of thymidylate synthase activity as a parameter for antitumor activity of 5-fluorouracil derivatives].
    Takeda S; Uchida J; Yamada Y; Unemi N; Fujii S
    Gan To Kagaku Ryoho; 1988 Jul; 15(7):2125-30. PubMed ID: 3395138
    [TBL] [Abstract][Full Text] [Related]  

  • 2. [Studies on the mechanism of antitumor activity of 5-FU and its derivatives--relationship between the inhibition of tumor growth and the inhibition of thymidylate synthetase in vivo].
    Nakamura H; Yu-Qin W; Miyauchi S; Nishioka N; Tanaka H; Harada N; Shirasaka T; Fujii S
    Gan To Kagaku Ryoho; 1984 May; 11(5):1049-55. PubMed ID: 6426401
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Relationship of in vivo antitumor activities of fluorinated pyrimidines to thymidylate synthase activity and intratumoral concentrations of 5-fluorouracil and uracil.
    Nio Y; Shiraishi T; Tsubono M; Morimoto H; Tseng CC; Kawabata K; Imai S; Tobe T
    Anticancer Res; 1991; 11(2):607-12. PubMed ID: 2064315
    [TBL] [Abstract][Full Text] [Related]  

  • 4. [Relationship between antitumor activity and the inhibition of thymidylate synthase after oral administration of UFT in nude mice bearing human tumor].
    Fujita M; Fujita F; Uchida J; Takeda S; Yamada Y; Taguchi T
    Gan To Kagaku Ryoho; 1990 Apr; 17(4 Pt 1):627-32. PubMed ID: 2108611
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.
    van Laar JA; van der Wilt CL; Rustum YM; Noordhuis P; Smid K; Pinedo HM; Peters GJ
    Clin Cancer Res; 1996 Aug; 2(8):1327-33. PubMed ID: 9816304
    [TBL] [Abstract][Full Text] [Related]  

  • 6. [Level of inhibition of thymidylate synthase activity and 5-fluorouracil in tumor tissues after administration of UFT or tegafur].
    Suzuki M; Sekiguchi I; Tamada T; Nishida M
    Nihon Gan Chiryo Gakkai Shi; 1989 Jul; 24(7):1399-404. PubMed ID: 2530293
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice.
    Ishikawa Y; Kubota T; Otani Y; Watanabe M; Teramoto T; Kumai K; Kitajima M; Takechi T; Okabe H; Fukushima M
    Clin Cancer Res; 1999 Apr; 5(4):883-9. PubMed ID: 10213225
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-fluorouracil prodrug in a colorectal tumor model.
    Cao S; Lu K; Tóth K; Slocum HK; Shirasaka T; Rustum YM
    Clin Cancer Res; 1999 Feb; 5(2):267-74. PubMed ID: 10037174
    [TBL] [Abstract][Full Text] [Related]  

  • 9. [The mechanism of biochemical modulation in methotrexate/5-fluorouracil sequential chemotherapy].
    Iba T; Yagi Y; Kidokoro A; Fukunaga M; Uchida J
    Gan To Kagaku Ryoho; 1994 Nov; 21(15):2591-4. PubMed ID: 7979418
    [TBL] [Abstract][Full Text] [Related]  

  • 10. [Innate resistance to thymidylate synthase inhibition after 5-fluorouracil treatment--a rationale of combined use of cisplatin and its optimal administration dose].
    Omura K; Hashimoto T; Kawakami K; Kanehira E; Watanabe T; Hirano K; Watanabe S; Watanabe Y; Shirasaka T
    Gan To Kagaku Ryoho; 1994 Sep; 21(12):2007-11. PubMed ID: 8085851
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A potential important role for thymidylate synthetase inhibition on antitumor activity of fluoropyrimidine and raltitexed.
    Kabeshima Y; Kubota T; Watanabe M; Saikawa Y; Nishibori H; Hasegawa H; Kitajima M
    Anticancer Res; 2002; 22(6A):3245-52. PubMed ID: 12530071
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The transfection of thymidylate synthase antisense suppresses oncogenic properties of a human colon cancer cell line and augments the antitumor effect of fluorouracil.
    Matsuoka K; Tsukuda K; Suda M; Kobayashi K; Ota T; Okita A; Watanabe K; Suzuki E; Murakami M; Doihara H; Shimizu N
    Int J Oncol; 2004 Jan; 24(1):217-22. PubMed ID: 14654960
    [TBL] [Abstract][Full Text] [Related]  

  • 13. [Significance of measuring 5-fluorouracil incorporated into RNA of tumor tissue as a parameter for the antitumor activity of 5-fluorouracil and its analogs].
    Uchida J; Umeno Y; Takeda S
    Gan To Kagaku Ryoho; 1992 May; 19(5):677-83. PubMed ID: 1580641
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Relationship between antitumor effect and metabolites of 5-fluorouracil in combination treatment with 5-fluorouracil and guanosine in ascites sarcoma 180 tumor system.
    Iigo M; Kuretani K; Hoshi A
    Cancer Res; 1983 Dec; 43(12 Pt 1):5687-94. PubMed ID: 6640523
    [TBL] [Abstract][Full Text] [Related]  

  • 15. [Invention of a tumor-selective 5-fluorouracil derivative named S-1 by biochemical modulation of 5-fluorouracil].
    Shirasaka T; Shimamoto Y; Kato T; Fukushima M
    Gan To Kagaku Ryoho; 1998 Feb; 25(3):371-84. PubMed ID: 9492831
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.
    Spears CP; Shahinian AH; Moran RG; Heidelberger C; Corbett TH
    Cancer Res; 1982 Feb; 42(2):450-6. PubMed ID: 6173112
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Peters GJ; Smitskamp-Wilms E; Smid K; Pinedo HM; Jansen G
    Cancer Res; 1999 Nov; 59(21):5529-35. PubMed ID: 10554030
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B; Pinedo HM; van Hensbergen Y; Smid K; Telleman F; Schoenmakers PS; van der Wilt CL; van Laar JA; Noordhuis P; Jansen G; Peters GJ
    Clin Cancer Res; 1999 Mar; 5(3):643-54. PubMed ID: 10100718
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.
    Van der Wilt CL; Pinedo HM; Smid K; Peters GJ
    Cancer Res; 1992 Sep; 52(18):4922-8. PubMed ID: 1516048
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Roles of thymidylate synthase and dihydropyrimidine dehydrogenase in tumor progression and sensitivity to 5-fluorouracil in human gastric cancer.
    Terashima M; Irinoda T; Fujiwara H; Nakaya T; Takagane A; Abe K; Yonezawa H; Oyama K; Inaba T; Saito K; Takechi T; Fukushima M
    Anticancer Res; 2002; 22(2A):761-8. PubMed ID: 12014648
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.