BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

135 related articles for article (PubMed ID: 33957093)

  • 1. Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.
    Wijaya LS; Trairatphisan P; Gabor A; Niemeijer M; Keet J; Alcalà Morera A; Snijders KE; Wink S; Yang H; Schildknecht S; Stevens JL; Bouwman P; Kamp H; Hengstler J; Beltman J; Leist M; Le Dévédec S; Saez-Rodriguez J; van de Water B
    Biochem Pharmacol; 2021 Aug; 190():114591. PubMed ID: 33957093
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury.
    Wink S; Hiemstra SW; Huppelschoten S; Klip JE; van de Water B
    Arch Toxicol; 2018 May; 92(5):1797-1814. PubMed ID: 29502165
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability.
    Hiemstra S; Ramaiahgari SC; Wink S; Callegaro G; Coonen M; Meerman J; Jennen D; van den Nieuwendijk K; Dankers A; Snoeys J; de Bont H; Price L; van de Water B
    Arch Toxicol; 2019 Oct; 93(10):2895-2911. PubMed ID: 31552476
    [TBL] [Abstract][Full Text] [Related]  

  • 4. High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.
    Wink S; Hiemstra S; Herpers B; van de Water B
    Arch Toxicol; 2017 Mar; 91(3):1367-1383. PubMed ID: 27358234
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.
    Herpers B; Wink S; Fredriksson L; Di Z; Hendriks G; Vrieling H; de Bont H; van de Water B
    Arch Toxicol; 2016 May; 90(5):1163-79. PubMed ID: 26026609
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability.
    Vlasveld M; Callegaro G; Fisher C; Eakins J; Walker P; Lok S; van Oost S; de Jong B; Pellegrino-Coppola D; Burger G; Wink S; van de Water B
    Liver Int; 2024 Mar; 44(3):760-775. PubMed ID: 38217387
    [TBL] [Abstract][Full Text] [Related]  

  • 7. CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.
    Uzi D; Barda L; Scaiewicz V; Mills M; Mueller T; Gonzalez-Rodriguez A; Valverde AM; Iwawaki T; Nahmias Y; Xavier R; Chung RT; Tirosh B; Shibolet O
    J Hepatol; 2013 Sep; 59(3):495-503. PubMed ID: 23665281
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2α-ATF4-CHOP pathway.
    Guo HL; Hassan HM; Ding PP; Wang SJ; Chen X; Wang T; Sun LX; Zhang LY; Jiang ZZ
    Toxicology; 2017 Mar; 378():65-75. PubMed ID: 28063906
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Psoralen induces hepatic toxicity through PERK and ATF6 related ER stress pathways in HepG2 cells.
    Yu Y; Yu R; Men W; Zhang P; Zhang Y; Song L; Zhou K
    Toxicol Mech Methods; 2020 Jan; 30(1):39-47. PubMed ID: 31364909
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity.
    Campos G; Schmidt-Heck W; Ghallab A; Rochlitz K; Pütter L; Medinas DB; Hetz C; Widera A; Cadenas C; Begher-Tibbe B; Reif R; Günther G; Sachinidis A; Hengstler JG; Godoy P
    Arch Toxicol; 2014 Jun; 88(6):1267-80. PubMed ID: 24748426
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of gammaherpesvirus lytic replication by endoplasmic reticulum stress-induced transcription factors ATF4 and CHOP.
    Zhou XC; Dong SH; Liu ZS; Liu S; Zhang CC; Liang XZ
    J Biol Chem; 2018 Feb; 293(8):2801-2814. PubMed ID: 29305424
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.
    Fredriksson L; Wink S; Herpers B; Benedetti G; Hadi M; de Bont H; Groothuis G; Luijten M; Danen E; de Graauw M; Meerman J; van de Water B
    Toxicol Sci; 2014 Jul; 140(1):144-59. PubMed ID: 24752500
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
    Babcock JT; Nguyen HB; He Y; Hendricks JW; Wek RC; Quilliam LA
    J Biol Chem; 2013 May; 288(22):15687-98. PubMed ID: 23612979
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.
    Fusakio ME; Willy JA; Wang Y; Mirek ET; Al Baghdadi RJ; Adams CM; Anthony TG; Wek RC
    Mol Biol Cell; 2016 May; 27(9):1536-51. PubMed ID: 26960794
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway.
    Ren Z; Chen S; Pak S; Guo L
    Chem Biol Interact; 2021 Jan; 334():109353. PubMed ID: 33309543
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Study of ATF4/CHOP axis-mediated mitochondrial unfolded protein response in neuronal apoptosis induced by methylmercury.
    Xu S; Liu H; Wang C; Deng Y; Xu B; Yang T; Liu W
    Food Chem Toxicol; 2023 Dec; 182():114190. PubMed ID: 37967789
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lipopolysaccharide preconditioning protects hepatocytes from ischemia/reperfusion injury (IRI) through inhibiting ATF4-CHOP pathway in mice.
    Rao J; Qin J; Qian X; Lu L; Wang P; Wu Z; Zhai Y; Zhang F; Li G; Wang X
    PLoS One; 2013; 8(6):e65568. PubMed ID: 23750267
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway.
    Cao J; Dai DL; Yao L; Yu HH; Ning B; Zhang Q; Chen J; Cheng WH; Shen W; Yang ZX
    Mol Cell Biochem; 2012 May; 364(1-2):115-29. PubMed ID: 22246806
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response.
    Hiramatsu N; Messah C; Han J; LaVail MM; Kaufman RJ; Lin JH
    Mol Biol Cell; 2014 May; 25(9):1411-20. PubMed ID: 24623724
    [TBL] [Abstract][Full Text] [Related]  

  • 20. PKCδ regulates death receptor 5 expression induced by PS-341 through ATF4-ATF3/CHOP axis in human lung cancer cells.
    Xu L; Su L; Liu X
    Mol Cancer Ther; 2012 Oct; 11(10):2174-82. PubMed ID: 22848091
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.