BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

345 related articles for article (PubMed ID: 33958721)

  • 1. Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma.
    Pietrobono S; Gaudio E; Gagliardi S; Zitani M; Carrassa L; Migliorini F; Petricci E; Manetti F; Makukhin N; Bond AG; Paradise BD; Ciulli A; Fernandez-Zapico ME; Bertoni F; Stecca B
    Oncogene; 2021 Jun; 40(22):3799-3814. PubMed ID: 33958721
    [TBL] [Abstract][Full Text] [Related]  

  • 2. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
    Gruber W; Hutzinger M; Elmer DP; Parigger T; Sternberg C; Cegielkowski L; Zaja M; Leban J; Michel S; Hamm S; Vitt D; Aberger F
    Oncotarget; 2016 Feb; 7(6):7134-48. PubMed ID: 26784250
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe.
    Pietrobono S; Santini R; Gagliardi S; Dapporto F; Colecchia D; Chiariello M; Leone C; Valoti M; Manetti F; Petricci E; Taddei M; Stecca B
    Cell Death Dis; 2018 Feb; 9(2):142. PubMed ID: 29396391
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.
    Gruber W; Peer E; Elmer DP; Sternberg C; Tesanovic S; Del Burgo P; Coni S; Canettieri G; Neureiter D; Bartz R; Kohlhof H; Vitt D; Aberger F
    Int J Cancer; 2018 Mar; 142(5):968-975. PubMed ID: 29055107
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hedgehog-GLI signaling drives self-renewal and tumorigenicity of human melanoma-initiating cells.
    Santini R; Vinci MC; Pandolfi S; Penachioni JY; Montagnani V; Olivito B; Gattai R; Pimpinelli N; Gerlini G; Borgognoni L; Stecca B
    Stem Cells; 2012 Sep; 30(9):1808-18. PubMed ID: 22730244
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Gli as a novel therapeutic target in malignant pleural mesothelioma.
    Li H; Lui N; Cheng T; Tseng HH; Yue D; Giroux-Leprieur E; Do HT; Sheng Q; Jin JQ; Luh TW; Jablons DM; He B
    PLoS One; 2013; 8(3):e57346. PubMed ID: 23483902
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.
    You M; Varona-Santos J; Singh S; Robbins DJ; Savaraj N; Nguyen DM
    J Thorac Cardiovasc Surg; 2014 Jan; 147(1):508-16. PubMed ID: 24094913
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.
    Mazumdar T; DeVecchio J; Agyeman A; Shi T; Houghton JA
    Oncotarget; 2011 Aug; 2(8):638-45. PubMed ID: 21860067
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.
    Benvenuto M; Masuelli L; De Smaele E; Fantini M; Mattera R; Cucchi D; Bonanno E; Di Stefano E; Frajese GV; Orlandi A; Screpanti I; Gulino A; Modesti A; Bei R
    Oncotarget; 2016 Feb; 7(8):9250-70. PubMed ID: 26843616
    [TBL] [Abstract][Full Text] [Related]  

  • 10. NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo.
    Jalili A; Mertz KD; Romanov J; Wagner C; Kalthoff F; Stuetz A; Pathria G; Gschaider M; Stingl G; Wagner SN
    PLoS One; 2013; 8(7):e69064. PubMed ID: 23935925
    [TBL] [Abstract][Full Text] [Related]  

  • 11. HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth.
    Pandolfi S; Montagnani V; Lapucci A; Stecca B
    Cell Death Differ; 2015 Dec; 22(12):2006-19. PubMed ID: 26024388
    [TBL] [Abstract][Full Text] [Related]  

  • 12. SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.
    Santini R; Pietrobono S; Pandolfi S; Montagnani V; D'Amico M; Penachioni JY; Vinci MC; Borgognoni L; Stecca B
    Oncogene; 2014 Sep; 33(38):4697-708. PubMed ID: 24681955
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells.
    Koike Y; Ohta Y; Saitoh W; Yamashita T; Kanomata N; Moriya T; Kurebayashi J
    Breast Cancer; 2017 Sep; 24(5):683-693. PubMed ID: 28144905
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of Hedgehog Signaling in Fibroblasts, Pancreatic, and Lung Tumor Cells by Oxy186, an Oxysterol Analogue with Drug-Like Properties.
    Wang F; Stappenbeck F; Parhami F
    Cells; 2019 May; 8(5):. PubMed ID: 31137846
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crosstalk between Hedgehog pathway and the glucocorticoid receptor pathway as a basis for combination therapy in T-cell acute lymphoblastic leukemia.
    Bongiovanni D; Tosello V; Saccomani V; Dalla Santa S; Amadori A; Zanovello P; Piovan E
    Oncogene; 2020 Oct; 39(42):6544-6555. PubMed ID: 32917954
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.
    Wickström M; Dyberg C; Shimokawa T; Milosevic J; Baryawno N; FuskevÄg OM; Larsson R; Kogner P; Zaphiropoulos PG; Johnsen JI
    Int J Cancer; 2013 Apr; 132(7):1516-24. PubMed ID: 22949014
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.
    Grzelak CA; Martelotto LG; Sigglekow ND; Patkunanathan B; Ajami K; Calabro SR; Dwyer BJ; Tirnitz-Parker JE; Watkins DN; Warner FJ; Shackel NA; McCaughan GW
    J Hepatol; 2014 Jan; 60(1):143-51. PubMed ID: 23978713
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold.
    Berardozzi S; Bernardi F; Infante P; Ingallina C; Toscano S; De Paolis E; Alfonsi R; Caimano M; Botta B; Mori M; Di Marcotullio L; Ghirga F
    Eur J Med Chem; 2018 Aug; 156():554-562. PubMed ID: 30025349
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.
    Guo J; Gao J; Li Z; Gong Y; Man X; Jin J; Wu H
    Cancer Lett; 2013 Oct; 339(2):185-94. PubMed ID: 23791879
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting the Hedgehog pathway with novel Gli1 hydrophobic tagging degraders.
    Li X; Sun R; Wu H; Zheng C; Long YQ
    Bioorg Chem; 2023 Sep; 138():106649. PubMed ID: 37307715
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.