200 related articles for article (PubMed ID: 34023639)
1. Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition.
Sadiq A; Mahnashi MH; Alyami BA; Alqahtani YS; Alqarni AO; Rashid U
Bioorg Chem; 2021 Jul; 112():104969. PubMed ID: 34023639
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.
Jan MS; Ahmad S; Hussain F; Ahmad A; Mahmood F; Rashid U; Abid OU; Ullah F; Ayaz M; Sadiq A
Eur J Med Chem; 2020 Jan; 186():111863. PubMed ID: 31740050
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of novel 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives as cytotoxic agents and COX-2/LOX inhibitors.
Lamie PF; Philoppes JN; Rárová L
Arch Pharm (Weinheim); 2018 Apr; 351(3-4):e1700311. PubMed ID: 29400411
[TBL] [Abstract][Full Text] [Related]
4. Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.
Cai H; Huang X; Xu S; Shen H; Zhang P; Huang Y; Jiang J; Sun Y; Jiang B; Wu X; Yao H; Xu J
Eur J Med Chem; 2016 Jan; 108():89-103. PubMed ID: 26638042
[TBL] [Abstract][Full Text] [Related]
5. Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
Jiang B; Huang X; Yao H; Jiang J; Wu X; Jiang S; Wang Q; Lu T; Xu J
Org Biomol Chem; 2014 Apr; 12(13):2114-27. PubMed ID: 24562695
[TBL] [Abstract][Full Text] [Related]
6. Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR.
Meshram MA; Bhise UO; Makhal PN; Kaki VR
Eur J Med Chem; 2021 Dec; 225():113804. PubMed ID: 34479036
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
J Med Chem; 2006 Mar; 49(5):1668-83. PubMed ID: 16509583
[TBL] [Abstract][Full Text] [Related]
8. Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS.
Xie L; Lee DY; Shang Y; Cao X; Wang S; Liao J; Zhang T; Dai R
Phytomedicine; 2020 Oct; 77():153284. PubMed ID: 32707371
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents.
Li Z; Wang ZC; Li X; Abbas M; Wu SY; Ren SZ; Liu QX; Liu Y; Chen PW; Duan YT; Lv PC; Zhu HL
Eur J Med Chem; 2019 May; 169():168-184. PubMed ID: 30877972
[TBL] [Abstract][Full Text] [Related]
10. Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids.
Abdu-Allah HHM; Abdelmoez AAB; Tarazi H; El-Shorbagi AA; El-Awady R
Bioorg Chem; 2020 Jan; 94():103378. PubMed ID: 31677858
[TBL] [Abstract][Full Text] [Related]
11. Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes: Synthesis, biological evaluation and docking study.
El-Nagar MKS; Abdu-Allah HHM; Salem OIA; Kafafy AN; Farghaly HSM
Bioorg Chem; 2018 Aug; 78():80-93. PubMed ID: 29550533
[TBL] [Abstract][Full Text] [Related]
12. Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
Ghanim AM; Rezq S; Ibrahim TS; Romero DG; Kothayer H
Eur J Med Chem; 2021 Jul; 219():113457. PubMed ID: 33892270
[TBL] [Abstract][Full Text] [Related]
13. Synthesis, biological evaluation and docking study of 1,3,4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX.
Omar YM; Abdu-Allah HHM; Abdel-Moty SG
Bioorg Chem; 2018 Oct; 80():461-471. PubMed ID: 29986191
[TBL] [Abstract][Full Text] [Related]
14. Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations.
Ahmad S; Mahnashi MH; Alyami BA; Alqahtani YS; Ullah F; Ayaz M; Tariq M; Sadiq A; Rashid U
Drug Des Devel Ther; 2021; 15():1299-1313. PubMed ID: 33790541
[TBL] [Abstract][Full Text] [Related]
15. Identification and development of thiazole leads as COX-2/5-LOX inhibitors through in-vitro and in-vivo biological evaluation for anti-inflammatory activity.
Jacob P J; Manju SL
Bioorg Chem; 2020 Jul; 100():103882. PubMed ID: 32361295
[TBL] [Abstract][Full Text] [Related]
16. New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.
El-Miligy MMM; Hazzaa AA; El-Messmary H; Nassra RA; El-Hawash SAM
Bioorg Chem; 2017 Jun; 72():102-115. PubMed ID: 28390993
[TBL] [Abstract][Full Text] [Related]
17. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
Maghraby MT; Abou-Ghadir OMF; Abdel-Moty SG; Ali AY; Salem OIA
Bioorg Med Chem; 2020 Apr; 28(7):115403. PubMed ID: 32127262
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2/5-LOX enzymes: Histopathological and docking studies.
Abdelgawad MA; Labib MB; Ali WAM; Kamel G; Azouz AA; El-Nahass ES
Bioorg Chem; 2018 Aug; 78():103-114. PubMed ID: 29550530
[TBL] [Abstract][Full Text] [Related]
19. Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.
Shen FQ; Wang ZC; Wu SY; Ren SZ; Man RJ; Wang BZ; Zhu HL
Bioorg Med Chem Lett; 2017 Aug; 27(16):3653-3660. PubMed ID: 28720504
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
Tan CM; Chen GS; Chen CS; Chang PT; Chern JW
Bioorg Med Chem; 2011 Nov; 19(21):6316-28. PubMed ID: 21958737
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
