BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

261 related articles for article (PubMed ID: 34023907)

  • 1. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress.
    Misra J; Holmes MJ; T Mirek E; Langevin M; Kim HG; Carlson KR; Watford M; Dong XC; Anthony TG; Wek RC
    Nucleic Acids Res; 2021 Jun; 49(10):5726-5742. PubMed ID: 34023907
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
    Nikonorova IA; Mirek ET; Signore CC; Goudie MP; Wek RC; Anthony TG
    J Biol Chem; 2018 Apr; 293(14):5005-5015. PubMed ID: 29449374
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
    Nikonorova IA; Al-Baghdadi RJT; Mirek ET; Wang Y; Goudie MP; Wetstein BB; Dixon JL; Hine C; Mitchell JR; Adams CM; Wek RC; Anthony TG
    J Biol Chem; 2017 Apr; 292(16):6786-6798. PubMed ID: 28242759
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
    Kim Y; Sundrud MS; Zhou C; Edenius M; Zocco D; Powers K; Zhang M; Mazitschek R; Rao A; Yeo CY; Noss EH; Brenner MB; Whitman M; Keller TL
    Proc Natl Acad Sci U S A; 2020 Apr; 117(16):8900-8911. PubMed ID: 32253314
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer.
    Chen GQ; Gong RH; Yang DJ; Zhang G; Lu AP; Yan SC; Lin SH; Bian ZX
    Cell Death Dis; 2017 May; 8(5):e2789. PubMed ID: 28492544
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling.
    Brüggenthies JB; Fiore A; Russier M; Bitsina C; Brötzmann J; Kordes S; Menninger S; Wolf A; Conti E; Eickhoff JE; Murray PJ
    J Biol Chem; 2022 Dec; 298(12):102629. PubMed ID: 36273589
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy.
    Battu S; Afroz S; Giddaluru J; Naz S; Huang W; Khumukcham SS; Khan RA; Bhat SY; Qureshi IA; Manavathi B; Khan AA; August A; Hasnain SE; Khan N
    PLoS Biol; 2018 Apr; 16(4):e2005317. PubMed ID: 29621237
    [TBL] [Abstract][Full Text] [Related]  

  • 8. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.
    Bunpo P; Dudley A; Cundiff JK; Cavener DR; Wek RC; Anthony TG
    J Biol Chem; 2009 Nov; 284(47):32742-9. PubMed ID: 19783659
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice.
    Pettit AP; Jonsson WO; Bargoud AR; Mirek ET; Peelor FF; Wang Y; Gettys TW; Kimball SR; Miller BF; Hamilton KL; Wek RC; Anthony TG
    J Nutr; 2017 Jun; 147(6):1031-1040. PubMed ID: 28446632
    [No Abstract]   [Full Text] [Related]  

  • 10. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.
    Averous J; Lambert-Langlais S; Mesclon F; Carraro V; Parry L; Jousse C; Bruhat A; Maurin AC; Pierre P; Proud CG; Fafournoux P
    Sci Rep; 2016 Jun; 6():27698. PubMed ID: 27297692
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.
    Al-Baghdadi RJT; Nikonorova IA; Mirek ET; Wang Y; Park J; Belden WJ; Wek RC; Anthony TG
    Sci Rep; 2017 Apr; 7(1):1272. PubMed ID: 28455513
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction.
    Wanders D; Stone KP; Forney LA; Cortez CC; Dille KN; Simon J; Xu M; Hotard EC; Nikonorova IA; Pettit AP; Anthony TG; Gettys TW
    Diabetes; 2016 Jun; 65(6):1499-510. PubMed ID: 26936965
    [TBL] [Abstract][Full Text] [Related]  

  • 13. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
    Ye J; Palm W; Peng M; King B; Lindsten T; Li MO; Koumenis C; Thompson CB
    Genes Dev; 2015 Nov; 29(22):2331-6. PubMed ID: 26543160
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
    Harding HP; Ordonez A; Allen F; Parts L; Inglis AJ; Williams RL; Ron D
    Elife; 2019 Nov; 8():. PubMed ID: 31749445
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency.
    Ge MK; Zhang C; Zhang N; He P; Cai HY; Li S; Wu S; Chu XL; Zhang YX; Ma HM; Xia L; Yang S; Yu JX; Yao SY; Zhou XL; Su B; Chen GQ; Shen SM
    Cell Metab; 2023 Dec; 35(12):2216-2230.e8. PubMed ID: 37979583
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.
    Bunpo P; Cundiff JK; Reinert RB; Wek RC; Aldrich CJ; Anthony TG
    J Nutr; 2010 Nov; 140(11):2020-7. PubMed ID: 20861212
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Genetic removal of eIF2α kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity.
    Zimmermann HR; Yang W; Beckelman BC; Kasica NP; Zhou X; Galli LD; Ryazanov AG; Ma T
    J Neurochem; 2018 Jul; 146(2):133-144. PubMed ID: 29337352
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR.
    Follo C; Vidoni C; Morani F; Ferraresi A; Seca C; Isidoro C
    Cell Commun Signal; 2019 May; 17(1):39. PubMed ID: 31046771
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.
    Wilson GJ; Bunpo P; Cundiff JK; Wek RC; Anthony TG
    Am J Physiol Endocrinol Metab; 2013 Nov; 305(9):E1124-33. PubMed ID: 24002574
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress.
    Qin P; Arabacilar P; Bernard RE; Bao W; Olzinski AR; Guo Y; Lal H; Eisennagel SH; Platchek MC; Xie W; Del Rosario J; Nayal M; Lu Q; Roethke T; Schnackenberg CG; Wright F; Quaile MP; Halsey WS; Hughes AM; Sathe GM; Livi GP; Kirkpatrick RB; Qu XA; Rajpal DK; Faelth Savitski M; Bantscheff M; Joberty G; Bergamini G; Force TL; Gatto GJ; Hu E; Willette RN
    J Am Heart Assoc; 2017 May; 6(5):. PubMed ID: 28487390
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.