BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

458 related articles for article (PubMed ID: 34040612)

  • 1. Characterization of DNA G-Quadruplex Structures in Human Immunoglobulin Heavy Variable (IGHV) Genes.
    Tang C; MacCarthy T
    Front Immunol; 2021; 12():671944. PubMed ID: 34040612
    [TBL] [Abstract][Full Text] [Related]  

  • 2. AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes.
    Tang C; Bagnara D; Chiorazzi N; Scharff MD; MacCarthy T
    Front Immunol; 2020; 11():788. PubMed ID: 32425948
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Interpretable deep learning reveals the role of an E-box motif in suppressing somatic hypermutation of AGCT motifs within human immunoglobulin variable regions.
    Tambe A; MacCarthy T; Pavri R
    Front Immunol; 2024; 15():1407470. PubMed ID: 38863710
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots.
    Krantsevich A; Tang C; MacCarthy T
    Front Immunol; 2020; 11():618409. PubMed ID: 33603748
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.
    Yuan C; Chu CC; Yan XJ; Bagnara D; Chiorazzi N; MacCarthy T
    PLoS One; 2017; 12(1):e0167602. PubMed ID: 28125682
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.
    Perlot T; Li G; Alt FW
    Proc Natl Acad Sci U S A; 2008 Mar; 105(10):3843-8. PubMed ID: 18292225
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells.
    Baughn LB; Kalis SL; MacCarthy T; Wei L; Fan M; Bergman A; Scharff MD
    mBio; 2011; 2(5):. PubMed ID: 21990614
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes.
    Duan Z; Baughn LB; Wang X; Zhang Y; Gupta V; MacCarthy T; Scharff MD; Yu G
    Proc Natl Acad Sci U S A; 2021 Jul; 118(29):. PubMed ID: 34253616
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region.
    Pan-Hammarström Q; Dai S; Zhao Y; van Dijk-Härd IF; Gatti RA; Børresen-Dale AL; Hammarström L
    J Immunol; 2003 Apr; 170(7):3707-16. PubMed ID: 12646636
    [TBL] [Abstract][Full Text] [Related]  

  • 10. RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination.
    Ribeiro de Almeida C; Dhir S; Dhir A; Moghaddam AE; Sattentau Q; Meinhart A; Proudfoot NJ
    Mol Cell; 2018 May; 70(4):650-662.e8. PubMed ID: 29731414
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Analysis of 6912 unselected somatic hypermutations in human VDJ rearrangements reveals lack of strand specificity and correlation between phase II substitution rates and distance to the nearest 3' activation-induced cytidine deaminase target.
    Ohm-Laursen L; Barington T
    J Immunol; 2007 Apr; 178(7):4322-34. PubMed ID: 17371989
    [TBL] [Abstract][Full Text] [Related]  

  • 12. DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.
    Schrader CE; Linehan EK; Ucher AJ; Bertocci B; Stavnezer J
    DNA Repair (Amst); 2013 Dec; 12(12):1087-93. PubMed ID: 24084171
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.
    Yewdell WT; Kim Y; Chowdhury P; Lau CM; Smolkin RM; Belcheva KT; Fernandez KC; Cols M; Yen WF; Vaidyanathan B; Angeletti D; McDermott AB; Yewdell JW; Sun JC; Chaudhuri J
    Immunity; 2020 Nov; 53(5):952-970.e11. PubMed ID: 33098766
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
    Chaudhuri J; Basu U; Zarrin A; Yan C; Franco S; Perlot T; Vuong B; Wang J; Phan RT; Datta A; Manis J; Alt FW
    Adv Immunol; 2007; 94():157-214. PubMed ID: 17560275
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Overlapping hotspots in CDRs are critical sites for V region diversification.
    Wei L; Chahwan R; Wang S; Wang X; Pham PT; Goodman MF; Bergman A; Scharff MD; MacCarthy T
    Proc Natl Acad Sci U S A; 2015 Feb; 112(7):E728-37. PubMed ID: 25646473
    [TBL] [Abstract][Full Text] [Related]  

  • 16. What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis?
    Oppezzo P; Dighiero G
    Curr Top Microbiol Immunol; 2005; 294():71-89. PubMed ID: 16323428
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line.
    Chezar I; Lobel-Lavi L; Steinitz M; Laskov R
    Mol Immunol; 2008 Nov; 46(1):80-90. PubMed ID: 18718665
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques.
    Guo K; Halemano K; Schmitt K; Katuwal M; Wang Y; Harper MS; Heilman KJ; Kuwata T; Stephens EB; Santiago ML
    Immunogenetics; 2015 Jul; 67(7):355-70. PubMed ID: 25994147
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes.
    Mayorov VI; Rogozin IB; Adkison LR; Frahm C; Kunkel TA; Pavlov YI
    BMC Immunol; 2005 Jun; 6():10. PubMed ID: 15949042
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Why does somatic hypermutation by AID require transcription of its target genes?
    Storb U
    Adv Immunol; 2014; 122():253-77. PubMed ID: 24507160
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.