BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

259 related articles for article (PubMed ID: 34041484)

  • 1. Fragment-based drug discovery: opportunities for organic synthesis.
    St Denis JD; Hall RJ; Murray CW; Heightman TD; Rees DC
    RSC Med Chem; 2020 Dec; 12(3):321-329. PubMed ID: 34041484
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries.
    Klein HF; Hamilton DJ; de Esch IJP; Wijtmans M; O'Brien P
    Drug Discov Today; 2022 Sep; 27(9):2484-2496. PubMed ID: 35636722
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery.
    Coutard B; Decroly E; Li C; Sharff A; Lescar J; Bricogne G; Barral K
    Antiviral Res; 2014 Jun; 106():61-70. PubMed ID: 24704437
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections.
    Kidd SL; Osberger TJ; Mateu N; Sore HF; Spring DR
    Front Chem; 2018; 6():460. PubMed ID: 30386766
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Fragment informatics and computational fragment-based drug design: an overview and update.
    Sheng C; Zhang W
    Med Res Rev; 2013 May; 33(3):554-98. PubMed ID: 22430881
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Fragment-based drug discovery for disorders of the central nervous system: designing better drugs piece by piece.
    Chan BWGL; Lynch NB; Tran W; Joyce JM; Savage GP; Meutermans W; Montgomery AP; Kassiou M
    Front Chem; 2024; 12():1379518. PubMed ID: 38698940
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Perspectives on Fragment-based Drug Discovery: A Strategy Applicable to Diverse Targets.
    Li Q; Kang C
    Curr Top Med Chem; 2021; 21(13):1099-1112. PubMed ID: 34348623
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enabling synthesis in fragment-based drug discovery (FBDD): microscale high-throughput optimisation of the medicinal chemist's toolbox reactions.
    Townley C; Branduardi D; Chessari G; Cons BD; Griffiths-Jones C; Hall RJ; Johnson CN; Ochi Y; Whibley S; Grainger R
    RSC Med Chem; 2023 Dec; 14(12):2699-2713. PubMed ID: 38107176
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In silico fragment-based drug design.
    Konteatis ZD
    Expert Opin Drug Discov; 2010 Nov; 5(11):1047-65. PubMed ID: 22827744
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fragment-based drug discovery-the importance of high-quality molecule libraries.
    Bon M; Bilsland A; Bower J; McAulay K
    Mol Oncol; 2022 Nov; 16(21):3761-3777. PubMed ID: 35749608
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities.
    Huang B; Kang D; Zhan P; Liu X
    Expert Opin Drug Discov; 2015 Dec; 10(12):1271-81. PubMed ID: 26372893
    [TBL] [Abstract][Full Text] [Related]  

  • 12. C-H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD).
    Chessari G; Grainger R; Holvey RS; Ludlow RF; Mortenson PN; Rees DC
    Chem Sci; 2021 Sep; 12(36):11976-11985. PubMed ID: 34667563
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease.
    Quek JP; Liu S; Zhang Z; Li Y; Ng EY; Loh YR; Hung AW; Luo D; Kang C
    Antiviral Res; 2020 Mar; 175():104707. PubMed ID: 31953156
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel approach of fragment-based lead discovery applied to renin inhibitors.
    Tawada M; Suzuki S; Imaeda Y; Oki H; Snell G; Behnke CA; Kondo M; Tarui N; Tanaka T; Kuroita T; Tomimoto M
    Bioorg Med Chem; 2016 Nov; 24(22):6066-6074. PubMed ID: 27720325
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery.
    Morrison CN; Prosser KE; Stokes RW; Cordes A; Metzler-Nolte N; Cohen SM
    Chem Sci; 2019 Dec; 11(5):1216-1225. PubMed ID: 34123246
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD).
    Palmer N; Peakman TM; Norton D; Rees DC
    Org Biomol Chem; 2016 Feb; 14(5):1599-610. PubMed ID: 26741115
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In Silico Structure-Based Approach for Group Efficiency Estimation in Fragment-Based Drug Design Using Evaluation of Fragment Contributions.
    Shulga DA; Ivanov NN; Palyulin VA
    Molecules; 2022 Mar; 27(6):. PubMed ID: 35335347
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Recent Development in Small Molecules for SARS-CoV-2 and the Opportunity for Fragment-Based Drug Discovery.
    Mahato S
    Med Chem; 2022; 18(8):847-858. PubMed ID: 35156586
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Fragment-Based Drug Discovery against Mycobacteria: The Success and Challenges.
    Togre NS; Vargas AM; Bhargavi G; Mallakuntla MK; Tiwari S
    Int J Mol Sci; 2022 Sep; 23(18):. PubMed ID: 36142582
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Experiences in fragment-based drug discovery.
    Murray CW; Verdonk ML; Rees DC
    Trends Pharmacol Sci; 2012 May; 33(5):224-32. PubMed ID: 22459076
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.