These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

215 related articles for article (PubMed ID: 34043193)

  • 1. Two Methods to Analyze LRRK2 Functions Under Lysosomal Stress: The Measurements of Cathepsin Release and Lysosomal Enlargement.
    Sakurai M; Kuwahara T
    Methods Mol Biol; 2021; 2322():63-72. PubMed ID: 34043193
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation.
    Kuwahara T; Funakawa K; Komori T; Sakurai M; Yoshii G; Eguchi T; Fukuda M; Iwatsubo T
    Neurobiol Dis; 2020 Nov; 145():105081. PubMed ID: 32919031
    [TBL] [Abstract][Full Text] [Related]  

  • 3. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
    Eguchi T; Kuwahara T; Sakurai M; Komori T; Fujimoto T; Ito G; Yoshimura SI; Harada A; Fukuda M; Koike M; Iwatsubo T
    Proc Natl Acad Sci U S A; 2018 Sep; 115(39):E9115-E9124. PubMed ID: 30209220
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
    Mir R; Tonelli F; Lis P; Macartney T; Polinski NK; Martinez TN; Chou MY; Howden AJM; König T; Hotzy C; Milenkovic I; Brücke T; Zimprich A; Sammler E; Alessi DR
    Biochem J; 2018 Jun; 475(11):1861-1883. PubMed ID: 29743203
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Lysosomal positioning regulates Rab10 phosphorylation at LRRK2
    Kluss JH; Beilina A; Williamson CD; Lewis PA; Cookson MR; Bonet-Ponce L
    Proc Natl Acad Sci U S A; 2022 Oct; 119(43):e2205492119. PubMed ID: 36256825
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
    Wang X; Bondar VV; Davis OB; Maloney MT; Agam M; Chin MY; Cheuk-Nga Ho A; Ghosh R; Leto DE; Joy D; Calvert MEK; Lewcock JW; Di Paolo G; Thorne RG; Sweeney ZK; Henry AG
    Elife; 2023 Oct; 12():. PubMed ID: 37874617
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanisms of lysosomal tubulation and sorting driven by LRRK2.
    Bonet-Ponce L; Kluss JH; Cookson MR
    Biochem Soc Trans; 2024 Aug; 52(4):1909-1919. PubMed ID: 39083004
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease.
    Taylor M; Alessi DR
    Curr Opin Cell Biol; 2020 Apr; 63():102-113. PubMed ID: 32036294
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of phospho-specific Rab protein antibodies to monitor
    Lis P; Burel S; Steger M; Mann M; Brown F; Diez F; Tonelli F; Holton JL; Ho PW; Ho SL; Chou MY; Polinski NK; Martinez TN; Davies P; Alessi DR
    Biochem J; 2018 Jan; 475(1):1-22. PubMed ID: 29127256
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
    Mamais A; Kluss JH; Bonet-Ponce L; Landeck N; Langston RG; Smith N; Beilina A; Kaganovich A; Ghosh MC; Pellegrini L; Kumaran R; Papazoglou I; Heaton GR; Bandopadhyay R; Maio N; Kim C; LaVoie MJ; Gershlick DC; Cookson MR
    PLoS Biol; 2021 Dec; 19(12):e3001480. PubMed ID: 34914695
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2.
    Komori T; Kuwahara T; Fujimoto T; Sakurai M; Koyama-Honda I; Fukuda M; Iwatsubo T
    J Cell Sci; 2023 Jul; 136(14):. PubMed ID: 37365944
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Role of LRRK2 in Intracellular Organelle Dynamics.
    Boecker CA
    J Mol Biol; 2023 Jun; 435(12):167998. PubMed ID: 36764357
    [TBL] [Abstract][Full Text] [Related]  

  • 13. LRRK2 mediates tubulation and vesicle sorting from lysosomes.
    Bonet-Ponce L; Beilina A; Williamson CD; Lindberg E; Kluss JH; Saez-Atienzar S; Landeck N; Kumaran R; Mamais A; Bleck CKE; Li Y; Cookson MR
    Sci Adv; 2020 Nov; 6(46):. PubMed ID: 33177079
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Detection of Substrate Phosphorylation of LRRK2 in Tissues and Cultured Cells.
    Ito K; Xu L; Ito G; Tomita T
    Methods Mol Biol; 2021; 2322():53-61. PubMed ID: 34043192
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.
    Rivero-Ríos P; Romo-Lozano M; Madero-Pérez J; Thomas AP; Biosa A; Greggio E; Hilfiker S
    J Biol Chem; 2019 Mar; 294(13):4738-4758. PubMed ID: 30709905
    [TBL] [Abstract][Full Text] [Related]  

  • 16. LRRK2 and idiopathic Parkinson's disease.
    Rocha EM; Keeney MT; Di Maio R; De Miranda BR; Greenamyre JT
    Trends Neurosci; 2022 Mar; 45(3):224-236. PubMed ID: 34991886
    [TBL] [Abstract][Full Text] [Related]  

  • 17. LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease.
    Hu D; Niu JY; Xiong J; Nie SK; Zeng F; Zhang ZH
    Curr Med Sci; 2018 Dec; 38(6):1012-1017. PubMed ID: 30536063
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
    Schapansky J; Khasnavis S; DeAndrade MP; Nardozzi JD; Falkson SR; Boyd JD; Sanderson JB; Bartels T; Melrose HL; LaVoie MJ
    Neurobiol Dis; 2018 Mar; 111():26-35. PubMed ID: 29246723
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.
    Cookson MR
    Biochem Soc Trans; 2016 Dec; 44(6):1603-1610. PubMed ID: 27913668
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons.
    Mamais A; Sanyal A; Fajfer A; Zykoski CG; Guldin M; Riley-DiPaolo A; Subrahmanian N; Gibbs W; Lin S; LaVoie MJ
    Stem Cell Reports; 2024 Feb; 19(2):163-173. PubMed ID: 38307024
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.