BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

256 related articles for article (PubMed ID: 34058053)

  • 1. Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases.
    Jane EP; Premkumar DR; Rajasundaram D; Thambireddy S; Reslink MC; Agnihotri S; Pollack IF
    Mol Oncol; 2022 Jan; 16(1):219-249. PubMed ID: 34058053
    [TBL] [Abstract][Full Text] [Related]  

  • 2. RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680).
    Martens S; Goossens V; Devisscher L; Hofmans S; Claeys P; Vuylsteke M; Takahashi N; Augustyns K; Vandenabeele P
    Cell Death Dis; 2018 Feb; 9(2):211. PubMed ID: 29434255
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Diversity of the pyruvate dehydrogenase kinase gene family in humans.
    Gudi R; Bowker-Kinley MM; Kedishvili NY; Zhao Y; Popov KM
    J Biol Chem; 1995 Dec; 270(48):28989-94. PubMed ID: 7499431
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer.
    Nunes-Xavier CE; Mingo J; Emaldi M; Flem-Karlsen K; Mælandsmo GM; Fodstad Ø; Llarena R; López JI; Pulido R
    Front Oncol; 2022; 12():873516. PubMed ID: 35692804
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Marked differences between two isoforms of human pyruvate dehydrogenase kinase.
    Baker JC; Yan X; Peng T; Kasten S; Roche TE
    J Biol Chem; 2000 May; 275(21):15773-81. PubMed ID: 10748134
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis.
    Jha MK; Song GJ; Lee MG; Jeoung NH; Go Y; Harris RA; Park DH; Kook H; Lee IK; Suk K
    J Neurosci; 2015 Oct; 35(42):14353-69. PubMed ID: 26490872
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.
    Tuganova A; Boulatnikov I; Popov KM
    Biochem J; 2002 Aug; 366(Pt 1):129-36. PubMed ID: 11978179
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
    Min BK; Park S; Kang HJ; Kim DW; Ham HJ; Ha CM; Choi BJ; Lee JY; Oh CJ; Yoo EK; Kim HE; Kim BG; Jeon JH; Hyeon DY; Hwang D; Kim YH; Lee CH; Lee T; Kim JW; Choi YK; Park KG; Chawla A; Lee J; Harris RA; Lee IK
    Front Immunol; 2019; 10():944. PubMed ID: 31134063
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression.
    Sugden MC; Kraus A; Harris RA; Holness MJ
    Biochem J; 2000 Mar; 346 Pt 3(Pt 3):651-7. PubMed ID: 10698691
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance.
    Woolbright BL; Choudhary D; Mikhalyuk A; Trammel C; Shanmugam S; Abbott E; Pilbeam CC; Taylor JA
    Mol Cancer Ther; 2018 Sep; 17(9):2004-2012. PubMed ID: 29907593
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.
    Holness MJ; Kraus A; Harris RA; Sugden MC
    Diabetes; 2000 May; 49(5):775-81. PubMed ID: 10905486
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.
    Kolobova E; Tuganova A; Boulatnikov I; Popov KM
    Biochem J; 2001 Aug; 358(Pt 1):69-77. PubMed ID: 11485553
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion.
    Sugden MC; Bulmer K; Augustine D; Holness MJ
    Diabetes; 2001 Dec; 50(12):2729-36. PubMed ID: 11723055
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis.
    Flora GD; Nayak MK; Ghatge M; Kumskova M; Patel RB; Chauhan AK
    Blood Adv; 2023 Jun; 7(11):2347-2359. PubMed ID: 36971790
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.
    Dunford EC; Herbst EA; Jeoung NH; Gittings W; Inglis JG; Vandenboom R; LeBlanc PJ; Harris RA; Peters SJ
    Am J Physiol Regul Integr Comp Physiol; 2011 Jun; 300(6):R1487-93. PubMed ID: 21411764
    [TBL] [Abstract][Full Text] [Related]  

  • 16. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
    Piao L; Sidhu VK; Fang YH; Ryan JJ; Parikh KS; Hong Z; Toth PT; Morrow E; Kutty S; Lopaschuk GD; Archer SL
    J Mol Med (Berl); 2013 Mar; 91(3):333-46. PubMed ID: 23247844
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.
    Korotchkina LG; Patel MS
    J Biol Chem; 2001 Oct; 276(40):37223-9. PubMed ID: 11486000
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation.
    Gan L; Yang Y; Liang Z; Zhang M; He Y; Zhang SL
    Eur J Med Chem; 2024 Jan; 264():116008. PubMed ID: 38056298
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
    Tao R; Xiong X; Harris RA; White MF; Dong XC
    PLoS One; 2013; 8(8):e71997. PubMed ID: 23940800
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.
    Sugden MC; Holness MJ
    Curr Drug Targets Immune Endocr Metabol Disord; 2002 Jul; 2(2):151-65. PubMed ID: 12476789
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.