These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 34072457)

  • 21. Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4.
    Hsu MH; Johnson EF
    J Biol Chem; 2019 May; 294(20):8015-8022. PubMed ID: 30926609
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Cytochrome P450-The Wonderful Nanomachine Revealed through Dynamic Simulations of the Catalytic Cycle.
    Dubey KD; Shaik S
    Acc Chem Res; 2019 Feb; 52(2):389-399. PubMed ID: 30633519
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism.
    Li H; Lampe JN
    Arch Biochem Biophys; 2019 Sep; 673():108078. PubMed ID: 31445893
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket.
    Ohkura K; Kawaguchi Y; Watanabe Y; Masubuchi Y; Shinohara Y; Hori H
    Anticancer Res; 2009 Mar; 29(3):935-42. PubMed ID: 19414330
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s.
    Yang Y; Wong SE; Lightstone FC
    PLoS One; 2014; 9(2):e87058. PubMed ID: 24498291
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen.
    Shahrokh K; Cheatham TE; Yost GS
    Biochim Biophys Acta; 2012 Oct; 1820(10):1605-17. PubMed ID: 22677141
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Unraveling the Ligand-Binding Sites of CYP3A4 by Molecular Dynamics Simulations with Solvent Probes.
    Feng Y; Gong C; Zhu J; Liu G; Tang Y; Li W
    J Chem Inf Model; 2024 Apr; 64(8):3451-3464. PubMed ID: 38593186
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer.
    Denisov IG; Grinkova YV; Baylon JL; Tajkhorshid E; Sligar SG
    Biochemistry; 2015 Apr; 54(13):2227-39. PubMed ID: 25777547
    [TBL] [Abstract][Full Text] [Related]  

  • 29. The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.
    Roberts AG; Yang J; Halpert JR; Nelson SD; Thummel KT; Atkins WM
    Biochemistry; 2011 Dec; 50(50):10804-18. PubMed ID: 21992114
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase.
    Ducharme J; Sevrioukova IF; Thibodeaux CJ; Auclair K
    Biochemistry; 2021 Jul; 60(28):2259-2271. PubMed ID: 34196520
    [TBL] [Abstract][Full Text] [Related]  

  • 31. HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation.
    Work HM; Hackett JC; Lampe JN
    Drug Metab Dispos; 2024 May; 52(6):516-525. PubMed ID: 38267095
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Loss of CYP3A7 gene induction by 1,25-dihydroxyvitamin D3 is caused by less binding of VDR to the proximal ER6 in CYP3A7 gene.
    Hara H; Yasunami Y; Adachi T
    Biochem Biophys Res Commun; 2004 Sep; 321(4):909-15. PubMed ID: 15358113
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution.
    Chuo SW; Liou SH; Wang LP; Britt RD; Poulos TL; Sevrioukova IF; Goodin DB
    Biochemistry; 2019 Sep; 58(37):3903-3910. PubMed ID: 31456404
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Theoretical Insights into Imidazolidine Oxidation of Imidacloprid by Cytochrome P450 3A4.
    Zheng ML; Li CR; Bai QH; Xiao H; Hu W; Xue Y; Gao JY
    J Mol Graph Model; 2018 Mar; 80():173-181. PubMed ID: 29414036
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth.
    Lacroix D; Sonnier M; Moncion A; Cheron G; Cresteil T
    Eur J Biochem; 1997 Jul; 247(2):625-34. PubMed ID: 9266706
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Development of bacterial expression system with high yield of CYP3A7, a human fetus-specific form of cytochrome P450.
    Inoue E; Takahashi Y; Imai Y; Kamataki T
    Biochem Biophys Res Commun; 2000 Mar; 269(2):623-7. PubMed ID: 10708604
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligand.
    Sevrioukova IF; Poulos TL
    J Biol Chem; 2012 Jan; 287(5):3510-7. PubMed ID: 22157006
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform.
    Kabir M; Padilha EC; Shah P; Huang R; Sakamuru S; Gonzalez E; Ye L; Hu X; Henderson MJ; Xia M; Xu X
    Front Pharmacol; 2022; 13():899536. PubMed ID: 35847040
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations.
    Müller CS; Knehans T; Davydov DR; Bounds PL; von Mandach U; Halpert JR; Caflisch A; Koppenol WH
    Biochemistry; 2015 Jan; 54(3):711-21. PubMed ID: 25545162
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A Mechanism-Based Model for the Prediction of the Metabolic Sites of Steroids Mediated by Cytochrome P450 3A4.
    Dai ZR; Ai CZ; Ge GB; He YQ; Wu JJ; Wang JY; Man HZ; Jia Y; Yang L
    Int J Mol Sci; 2015 Jun; 16(7):14677-94. PubMed ID: 26133240
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.