297 related articles for article (PubMed ID: 34073805)
1. State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis.
Deslignière E; Ehkirch A; Duivelshof BL; Toftevall H; Sjögren J; Guillarme D; D'Atri V; Beck A; Hernandez-Alba O; Cianférani S
Pharmaceuticals (Basel); 2021 May; 14(6):. PubMed ID: 34073805
[TBL] [Abstract][Full Text] [Related]
2. Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.
Botzanowski T; Erb S; Hernandez-Alba O; Ehkirch A; Colas O; Wagner-Rousset E; Rabuka D; Beck A; Drake PM; Cianférani S
MAbs; 2017 Jul; 9(5):801-811. PubMed ID: 28406343
[TBL] [Abstract][Full Text] [Related]
3. Quantitative collision-induced unfolding differentiates model antibody-drug conjugates.
Tian Y; Lippens JL; Netirojjanakul C; Campuzano IDG; Ruotolo BT
Protein Sci; 2019 Mar; 28(3):598-608. PubMed ID: 30499138
[TBL] [Abstract][Full Text] [Related]
4. A Combination of Native LC-MS Approaches for the Comprehensive Characterization of the Antibody-Drug Conjugate Trastuzumab Deruxtecan.
Deslignière E; Diemer H; Erb S; Coliat P; Pivot X; Detappe A; Hernandez-Alba O; Cianférani S
Front Biosci (Landmark Ed); 2022 Oct; 27(10):290. PubMed ID: 36336868
[TBL] [Abstract][Full Text] [Related]
5. Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.
Debaene F; Boeuf A; Wagner-Rousset E; Colas O; Ayoub D; Corvaïa N; Van Dorsselaer A; Beck A; Cianférani S
Anal Chem; 2014 Nov; 86(21):10674-83. PubMed ID: 25270580
[TBL] [Abstract][Full Text] [Related]
6. Analysis of ADCs by Native Mass Spectrometry.
Hernandez-Alba O; Ehkirch A; Beck A; Cianférani S
Methods Mol Biol; 2020; 2078():197-211. PubMed ID: 31643058
[TBL] [Abstract][Full Text] [Related]
7. Conjugation site analysis of antibody-drug-conjugates (ADCs) by signature ion fingerprinting and normalized area quantitation approach using nano-liquid chromatography coupled to high resolution mass spectrometry.
Sang H; Lu G; Liu Y; Hu Q; Xing W; Cui D; Zhou F; Zhang J; Hao H; Wang G; Ye H
Anal Chim Acta; 2017 Feb; 955():67-78. PubMed ID: 28088282
[TBL] [Abstract][Full Text] [Related]
8. Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related products.
Ehkirch A; Hernandez-Alba O; Colas O; Beck A; Guillarme D; Cianférani S
J Chromatogr B Analyt Technol Biomed Life Sci; 2018 Jun; 1086():176-183. PubMed ID: 29684909
[TBL] [Abstract][Full Text] [Related]
9. A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry.
Hernandez-Alba O; Houel S; Hessmann S; Erb S; Rabuka D; Huguet R; Josephs J; Beck A; Drake PM; Cianférani S
J Am Soc Mass Spectrom; 2019 Nov; 30(11):2419-2429. PubMed ID: 31429052
[TBL] [Abstract][Full Text] [Related]
10. Practical approaches for overcoming challenges in heightened characterization of antibody-drug conjugates with new methodologies and ultrahigh-resolution mass spectrometry.
Friese OV; Smith JN; Brown PW; Rouse JC
MAbs; 2018 Apr; 10(3):335-345. PubMed ID: 29393747
[TBL] [Abstract][Full Text] [Related]
11. Toward Automation of Collision-Induced Unfolding Experiments through Online Size Exclusion Chromatography Coupled to Native Mass Spectrometry.
Deslignière E; Ehkirch A; Botzanowski T; Beck A; Hernandez-Alba O; Cianférani S
Anal Chem; 2020 Oct; 92(19):12900-12908. PubMed ID: 32886492
[TBL] [Abstract][Full Text] [Related]
12. Glycan-Mediated Technology for Obtaining Homogeneous Site-Specific Conjugated Antibody-Drug Conjugates: Synthesis and Analytical Characterization by Using Complementary Middle-up LC/HRMS Analysis.
Duivelshof BL; Deslignière E; Hernandez-Alba O; Ehkirch A; Toftevall H; Sjögren J; Cianferani S; Beck A; Guillarme D; D'Atri V
Anal Chem; 2020 Jun; 92(12):8170-8177. PubMed ID: 32407621
[TBL] [Abstract][Full Text] [Related]
13. Combination of IM-Based Approaches to Unravel the Coexistence of Two Conformers on a Therapeutic Multispecific mAb.
Deslignière E; Ollivier S; Ehkirch A; Martelet A; Ropartz D; Lechat N; Hernandez-Alba O; Menet JM; Clavier S; Rogniaux H; Genet B; Cianférani S
Anal Chem; 2022 Jun; 94(22):7981-7989. PubMed ID: 35604400
[TBL] [Abstract][Full Text] [Related]
14. Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.
Behrens CR; Ha EH; Chinn LL; Bowers S; Probst G; Fitch-Bruhns M; Monteon J; Valdiosera A; Bermudez A; Liao-Chan S; Wong T; Melnick J; Theunissen JW; Flory MR; Houser D; Venstrom K; Levashova Z; Sauer P; Migone TS; van der Horst EH; Halcomb RL; Jackson DY
Mol Pharm; 2015 Nov; 12(11):3986-98. PubMed ID: 26393951
[TBL] [Abstract][Full Text] [Related]
15. Online Collision-Induced Unfolding of Therapeutic Monoclonal Antibody Glyco-Variants through Direct Hyphenation of Cation Exchange Chromatography with Native Ion Mobility-Mass Spectrometry.
van Schaick G; Domínguez-Vega E; Castel J; Wuhrer M; Hernandez-Alba O; Cianférani S
Anal Chem; 2023 Feb; 95(8):3932-3939. PubMed ID: 36791123
[TBL] [Abstract][Full Text] [Related]
16. Conjugation Site Analysis of Lysine-Conjugated ADCs.
Sang H; Wan N; Lu G; Tian Y; Wang G; Ye H
Methods Mol Biol; 2020; 2078():235-250. PubMed ID: 31643061
[TBL] [Abstract][Full Text] [Related]
17. Drug deconjugation-assisted peptide mapping by LC-MS/MS to identify conjugation sites and quantify site occupancy for antibody-drug conjugates.
Wang T; Huang ZA; Zhou M; Wang R; Li Y; Guo L; Cao X; Huang J
J Pharm Biomed Anal; 2024 Jun; 243():116098. PubMed ID: 38493753
[TBL] [Abstract][Full Text] [Related]
18. Current methods for the synthesis of homogeneous antibody-drug conjugates.
Sochaj AM; Świderska KW; Otlewski J
Biotechnol Adv; 2015 Nov; 33(6 Pt 1):775-84. PubMed ID: 25981886
[TBL] [Abstract][Full Text] [Related]
19. High-Throughput Multi-attribute Analysis of Antibody-Drug Conjugates Enabled by Trapped Ion Mobility Spectrometry and Top-Down Mass Spectrometry.
Larson EJ; Roberts DS; Melby JA; Buck KM; Zhu Y; Zhou S; Han L; Zhang Q; Ge Y
Anal Chem; 2021 Jul; 93(29):10013-10021. PubMed ID: 34258999
[TBL] [Abstract][Full Text] [Related]
20. Native size-exclusion chromatography-mass spectrometry: suitability for antibody-drug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levels.
Jones J; Pack L; Hunter JH; Valliere-Douglass JF
MAbs; 2020; 12(1):1682895. PubMed ID: 31769727
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
