BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 34080888)

  • 1. Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity.
    Ruan DT; Tang N; Akasaka H; Lu R; Ruan KH
    Future Med Chem; 2021 Jul; 13(13):1091-1103. PubMed ID: 34080888
    [No Abstract]   [Full Text] [Related]  

  • 2. Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2.
    Akasaka H; So SP; Ruan KH
    Biochemistry; 2015 Jun; 54(23):3707-15. PubMed ID: 25988363
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
    Ochiai T; Sasaki Y; Kuwata H; Nakatani Y; Yokoyama C; Hara S
    Biochem Biophys Res Commun; 2021 Mar; 546():124-129. PubMed ID: 33582554
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and characterization of lead compounds as anti-inflammatory drugs targeting mPGES-1 via enzymelink screening.
    Lu R; Akasaka H; Ruan KH
    Future Med Chem; 2023 May; 15(9):757-767. PubMed ID: 37248701
    [No Abstract]   [Full Text] [Related]  

  • 5. Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli.
    Galán M; Miguel M; Beltrán AE; Rodríguez C; García-Redondo AB; Rodríguez-Calvo R; Alonso MJ; Martínez-González J; Salaices M
    J Hypertens; 2011 Mar; 29(3):529-36. PubMed ID: 21169864
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
    Sasaki Y; Kamiyama S; Kamiyama A; Matsumoto K; Akatsu M; Nakatani Y; Kuwata H; Ishikawa Y; Ishii T; Yokoyama C; Hara S
    Sci Rep; 2015 Nov; 5():17376. PubMed ID: 26611322
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Divergent roles of prostacyclin and PGE
    Bergqvist F; Carr AJ; Wheway K; Watkins B; Oppermann U; Jakobsson PJ; Dakin SG
    Arthritis Res Ther; 2019 Mar; 21(1):74. PubMed ID: 30867043
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis.
    Hayakawa T; Fujiwara Y; Hamaguchi M; Sugawa T; Okuyama M; Sasaki E; Watanabe T; Tominaga K; Oshitani N; Higuchi K; Arakawa T
    Gut; 2006 Apr; 55(4):450-6. PubMed ID: 16210398
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of prostacyclin synthase in carcinogenesis.
    Sasaki Y; Ochiai T; Takamura M; Kondo Y; Yokoyama C; Hara S
    Prostaglandins Other Lipid Mediat; 2017 Nov; 133():49-52. PubMed ID: 28506876
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin.
    Ruan KH; Deng H; So SP
    Biochemistry; 2006 Nov; 45(47):14003-11. PubMed ID: 17115695
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2.
    Ruan KH; Cervantes V; So SP
    Protein Eng Des Sel; 2009 Dec; 22(12):733-40. PubMed ID: 19850676
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer.
    Shyue SK; Tsai MJ; Liou JY; Willerson JT; Wu KK
    Circulation; 2001 Apr; 103(16):2090-5. PubMed ID: 11319200
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol.
    Rörsch F; Wobst I; Zettl H; Schubert-Zsilavecz M; Grösch S; Geisslinger G; Schneider G; Proschak E
    J Med Chem; 2010 Jan; 53(2):911-5. PubMed ID: 20025212
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Augmented renal prostacyclin by intrarenal bicistronic cyclo-oxygenase-1/prostacyclin synthase gene transfer attenuates renal ischemia-reperfusion injury.
    Yang CC; Chen KH; Hsu SP; Chien CT
    Transplantation; 2013 Dec; 96(12):1043-51. PubMed ID: 24092384
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential expression and regulation of cylooxygenases, prostaglandin E synthases and prostacyclin synthase in rat uterus during the peri-implantation period.
    Cong J; Diao HL; Zhao YC; Ni H; Yan YQ; Yang ZM
    Reproduction; 2006 Jan; 131(1):139-51. PubMed ID: 16388017
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis.
    Kapoor M; Kojima F; Qian M; Yang L; Crofford LJ
    FASEB J; 2006 Nov; 20(13):2387-9. PubMed ID: 17023389
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Establishment of a cell-based drug screening system for identifying selective down-regulators of mPGES-1.
    Guo L; Lian JH; Ji W; Hu WR; Wu GL; Gong BQ
    Inflamm Res; 2006 Mar; 55(3):114-8. PubMed ID: 16673154
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage.
    Ling QL; Mohite AJ; Murdoch E; Akasaka H; Li QY; So SP; Ruan KH
    Sci Rep; 2018 Jan; 8(1):1653. PubMed ID: 29374184
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Prostacyclin Synthase as an Ambivalent Regulator of Inflammatory Reactions.
    Ochiai T; Honsawa T; Sasaki Y; Hara S
    Biol Pharm Bull; 2022; 45(8):979-984. PubMed ID: 35908907
    [TBL] [Abstract][Full Text] [Related]  

  • 20. An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector.
    Ruan KH; So SP; Cervantes V; Wu H; Wijaya C; Jentzen RR
    FEBS J; 2008 Dec; 275(23):5820-9. PubMed ID: 19021758
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.