These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

124 related articles for article (PubMed ID: 34090207)

  • 21. A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
    Du T; Lin S; Ji M; Xue N; Liu Y; Zhang Z; Zhang K; Zhang J; Zhang Y; Wang Q; Sheng L; Li Y; Lu D; Chen X; Xu H
    Cancer Lett; 2020 Dec; 495():22-32. PubMed ID: 32931884
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Development of novel ADCs: conjugation of tubulysin analogues to trastuzumab monitored by dual radiolabeling.
    Cohen R; Vugts DJ; Visser GW; Stigter-van Walsum M; Bolijn M; Spiga M; Lazzari P; Shankar S; Sani M; Zanda M; van Dongen GA
    Cancer Res; 2014 Oct; 74(20):5700-10. PubMed ID: 25145670
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.
    Gherbovet O; Sánchez-Murcia PA; García Alvarez MC; Bignon J; Thoret S; Gago F; Roussi F
    Org Biomol Chem; 2015 Mar; 13(10):3144-54. PubMed ID: 25634805
    [TBL] [Abstract][Full Text] [Related]  

  • 24. High-resolution model of the microtubule.
    Nogales E; Whittaker M; Milligan RA; Downing KH
    Cell; 1999 Jan; 96(1):79-88. PubMed ID: 9989499
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria.
    Khalil MW; Sasse F; Lünsdorf H; Elnakady YA; Reichenbach H
    Chembiochem; 2006 Apr; 7(4):678-83. PubMed ID: 16491500
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Structural comparison of the interaction of tubulin with various ligands affecting microtubule dynamics.
    Stec-Martyna E; Ponassi M; Miele M; Parodi S; Felli L; Rosano C
    Curr Cancer Drug Targets; 2012 Jul; 12(6):658-66. PubMed ID: 22385515
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Structural plasticity of tubulin assembly probed by vinca-domain ligands.
    Ranaivoson FM; Gigant B; Berritt S; Joullié M; Knossow M
    Acta Crystallogr D Biol Crystallogr; 2012 Aug; 68(Pt 8):927-34. PubMed ID: 22868758
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.
    Waight AB; Bargsten K; Doronina S; Steinmetz MO; Sussman D; Prota AE
    PLoS One; 2016; 11(8):e0160890. PubMed ID: 27518442
    [TBL] [Abstract][Full Text] [Related]  

  • 29. One-pot synthesis of vinca alkaloids-phomopsin hybrids.
    Gherbovet O; Coderch C; García Alvarez MC; Bignon J; Thoret S; Guéritte F; Gago F; Roussi F
    J Med Chem; 2014 Jun; 57(12):5470-6. PubMed ID: 24871162
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Molecular mechanism of action of microtubule-stabilizing anticancer agents.
    Prota AE; Bargsten K; Zurwerra D; Field JJ; Díaz JF; Altmann KH; Steinmetz MO
    Science; 2013 Feb; 339(6119):587-90. PubMed ID: 23287720
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.
    Aldaz H; Rice LM; Stearns T; Agard DA
    Nature; 2005 May; 435(7041):523-7. PubMed ID: 15917813
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structural basis for the regulation of tubulin by vinblastine.
    Gigant B; Wang C; Ravelli RB; Roussi F; Steinmetz MO; Curmi PA; Sobel A; Knossow M
    Nature; 2005 May; 435(7041):519-22. PubMed ID: 15917812
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity.
    Zhang D; Kanakkanthara A
    Cancers (Basel); 2020 Jun; 12(7):. PubMed ID: 32610496
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
    Wang Y; Zhang H; Gigant B; Yu Y; Wu Y; Chen X; Lai Q; Yang Z; Chen Q; Yang J
    FEBS J; 2016 Jan; 283(1):102-11. PubMed ID: 26462166
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1
    Wang Q; Arnst KE; Wang Y; Kumar G; Ma D; White SW; Miller DD; Li W; Li W
    J Med Chem; 2019 Jul; 62(14):6734-6750. PubMed ID: 31251599
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors.
    Staben LR; Yu SF; Chen J; Yan G; Xu Z; Del Rosario G; Lau JT; Liu L; Guo J; Zheng B; Cruz-Chuh JD; Lee BC; Ohri R; Cai W; Zhou H; Kozak KR; Xu K; Lewis Phillips GD; Lu J; Wai J; Polson AG; Pillow TH
    ACS Med Chem Lett; 2017 Oct; 8(10):1037-1041. PubMed ID: 29057047
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.
    Wieczorek M; Tcherkezian J; Bernier C; Prota AE; Chaaban S; Rolland Y; Godbout C; Hancock MA; Arezzo JC; Ocal O; Rocha C; Olieric N; Hall A; Ding H; Bramoullé A; Annis MG; Zogopoulos G; Harran PG; Wilkie TM; Brekken RA; Siegel PM; Steinmetz MO; Shore GC; Brouhard GJ; Roulston A
    Sci Transl Med; 2016 Nov; 8(365):365ra159. PubMed ID: 27856798
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The determinants that govern microtubule assembly from the atomic structure of GTP-tubulin.
    Nawrotek A; Knossow M; Gigant B
    J Mol Biol; 2011 Sep; 412(1):35-42. PubMed ID: 21787788
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Structure of 4'-demethylepipodophyllotoxin in complex with tubulin provides a rationale for drug design.
    Niu L; Wang Y; Wang C; Wang Y; Jiang X; Ma L; Wu C; Yu Y; Chen Q
    Biochem Biophys Res Commun; 2017 Nov; 493(1):718-722. PubMed ID: 28864414
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics.
    Thompson P; Fleming R; Bezabeh B; Huang F; Mao S; Chen C; Harper J; Zhong H; Gao X; Yu XQ; Hinrichs MJ; Reed M; Kamal A; Strout P; Cho S; Woods R; Hollingsworth RE; Dixit R; Wu H; Gao C; Dimasi N
    J Control Release; 2016 Aug; 236():100-16. PubMed ID: 27327768
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.