BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 34097389)

  • 1. Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents.
    Peng X; Chen J; Li L; Sun Z; Liu J; Ren Y; Huang J; Chen J
    J Med Chem; 2021 Jun; 64(12):8447-8473. PubMed ID: 34097389
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.
    Peng X; Li L; Chen J; Ren Y; Liu J; Yu Z; Cao H; Chen J
    J Med Chem; 2022 Feb; 65(3):2434-2457. PubMed ID: 35043615
    [TBL] [Abstract][Full Text] [Related]  

  • 3. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition.
    Singh A; Chang TY; Kaur N; Hsu KC; Yen Y; Lin TE; Lai MJ; Lee SB; Liou JP
    Eur J Med Chem; 2021 Apr; 215():113169. PubMed ID: 33588178
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity.
    Mourad AAE; Mourad MAE; Jones PG
    Drug Des Devel Ther; 2020; 14():3111-3130. PubMed ID: 32848361
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
    Wang Y; Sun M; Wang Y; Qin J; Zhang Y; Pang Y; Yao Y; Yang H; Duan Y
    Eur J Med Chem; 2021 Dec; 225():113790. PubMed ID: 34454126
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities.
    Komuraiah B; Ren Y; Xue M; Cheng B; Liu J; Liu Y; Chen J
    Chem Biol Drug Des; 2021 May; 97(5):1109-1116. PubMed ID: 33638903
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.
    Wang B; Chen X; Gao J; Su L; Zhang L; Xu H; Luan Y
    Bioorg Med Chem Lett; 2019 Sep; 29(18):2638-2645. PubMed ID: 31400938
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.
    Yang Z; Shen M; Tang M; Zhang W; Cui X; Zhang Z; Pei H; Li Y; Hu M; Bai P; Chen L
    Eur J Med Chem; 2019 Sep; 178():116-130. PubMed ID: 31177073
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors.
    Shuai W; Li X; Li W; Xu F; Lu L; Yao H; Yang L; Zhu H; Xu S; Zhu Z; Xu J
    Eur J Med Chem; 2020 Jul; 197():112308. PubMed ID: 32339853
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
    Chen H; Deng S; Albadari N; Yun MK; Zhang S; Li Y; Ma D; Parke DN; Yang L; Seagroves TN; White SW; Miller DD; Li W
    J Med Chem; 2021 Aug; 64(16):12049-12074. PubMed ID: 34378386
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, biological evaluation, and molecular docking analysis of novel linker-less benzamide based potent and selective HDAC3 inhibitors.
    Routholla G; Pulya S; Patel T; Abdul Amin S; Adhikari N; Biswas S; Jha T; Ghosh B
    Bioorg Chem; 2021 Sep; 114():105050. PubMed ID: 34120025
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.
    Zhang X; Kong Y; Zhang J; Su M; Zhou Y; Zang Y; Li J; Chen Y; Fang Y; Zhang X; Lu W
    Eur J Med Chem; 2015 May; 95():127-35. PubMed ID: 25805446
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
    Li Y; Liu Y; Zhu Z; Yan W; Zhang C; Yang Z; Bai P; Tang M; Shi M; He W; Fu S; Liu J; Han K; Li J; Xie L; Ye H; Yang J; Chen L
    J Med Chem; 2022 Feb; 65(3):2675-2693. PubMed ID: 35084853
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of a 2,6-diarylpyridine-based hydroxamic acid derivative as novel histone deacetylase 8 and tubulin dual inhibitor for the treatment of neuroblastoma.
    Tang H; Liang Y; Shen H; Cai S; Yu M; Fan H; Ding K; Wang Y
    Bioorg Chem; 2022 Nov; 128():106112. PubMed ID: 36070628
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study.
    Ma W; Chen P; Huo X; Ma Y; Li Y; Diao P; Yang F; Zheng S; Hu M; You W; Zhao P
    Eur J Med Chem; 2020 Dec; 208():112847. PubMed ID: 33022479
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.
    Wang G; Peng F; Cao D; Yang Z; Han X; Liu J; Wu W; He L; Ma L; Chen J; Sang Y; Xiang M; Peng A; Wei Y; Chen L
    Bioorg Med Chem; 2013 Nov; 21(21):6844-54. PubMed ID: 23993668
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo.
    Li YR; Liu FF; Liu WB; Zhang YF; Tian XY; Fu XJ; Xu Y; Song J; Zhang SY
    Biochem Pharmacol; 2022 Jul; 201():115070. PubMed ID: 35526597
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of novel CA-4 analogs as dual inhibitors of tubulin polymerization and PD-1/PD-L1 interaction for cancer treatment.
    Yang X; Cheng B; Xiao Y; Xue M; Liu T; Cao H; Chen J
    Eur J Med Chem; 2021 Mar; 213():113058. PubMed ID: 33280898
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site.
    Shao YY; Yin Y; Lian BP; Leng JF; Xia YZ; Kong LY
    Eur J Med Chem; 2020 Mar; 190():112105. PubMed ID: 32035399
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site.
    Li W; Sun H; Xu F; Shuai W; Liu J; Xu S; Yao H; Ma C; Zhu Z; Xu J
    Bioorg Chem; 2019 Apr; 85():49-59. PubMed ID: 30599412
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.