These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

166 related articles for article (PubMed ID: 34125095)

  • 1. Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source.
    Douangamath A; Powell A; Fearon D; Collins PM; Talon R; Krojer T; Skyner R; Brandao-Neto J; Dunnett L; Dias A; Aimon A; Pearce NM; Wild C; Gorrie-Stone T; von Delft F
    J Vis Exp; 2021 May; (171):. PubMed ID: 34125095
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening.
    Collins PM; Douangamath A; Talon R; Dias A; Brandao-Neto J; Krojer T; von Delft F
    Methods Enzymol; 2018; 610():251-264. PubMed ID: 30390801
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking.
    Metz A; Wollenhaupt J; Glöckner S; Messini N; Huber S; Barthel T; Merabet A; Gerber HD; Heine A; Klebe G; Weiss MS
    Acta Crystallogr D Struct Biol; 2021 Sep; 77(Pt 9):1168-1182. PubMed ID: 34473087
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystallographic fragment screening.
    Badger J
    Methods Mol Biol; 2012; 841():161-77. PubMed ID: 22222452
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery.
    Coutard B; Decroly E; Li C; Sharff A; Lescar J; Bricogne G; Barral K
    Antiviral Res; 2014 Jun; 106():61-70. PubMed ID: 24704437
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.
    Thomas SE; Collins P; James RH; Mendes V; Charoensutthivarakul S; Radoux C; Abell C; Coyne AG; Floto RA; von Delft F; Blundell TL
    Philos Trans A Math Phys Eng Sci; 2019 Jun; 377(2147):20180422. PubMed ID: 31030650
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin.
    Wollenhaupt J; Barthel T; Lima GMA; Metz A; Wallacher D; Jagudin E; Huschmann FU; Hauß T; Feiler CG; Gerlach M; Hellmig M; Förster R; Steffien M; Heine A; Klebe G; Mueller U; Weiss MS
    J Vis Exp; 2021 Mar; (169):. PubMed ID: 33749678
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Fast fragment- and compound-screening pipeline at the Swiss Light Source.
    Kaminski JW; Vera L; Stegmann DP; Vering J; Eris D; Smith KML; Huang CY; Meier N; Steuber J; Wang M; Fritz G; Wojdyla JA; Sharpe ME
    Acta Crystallogr D Struct Biol; 2022 Mar; 78(Pt 3):328-336. PubMed ID: 35234147
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Protein X-ray Crystallography and Drug Discovery.
    Maveyraud L; Mourey L
    Molecules; 2020 Feb; 25(5):. PubMed ID: 32106588
    [TBL] [Abstract][Full Text] [Related]  

  • 10. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery.
    Tsai Y; McPhillips SE; González A; McPhillips TM; Zinn D; Cohen AE; Feese MD; Bushnell D; Tiefenbrunn T; Stout CD; Ludaescher B; Hedman B; Hodgson KO; Soltis SM
    Acta Crystallogr D Biol Crystallogr; 2013 May; 69(Pt 5):796-803. PubMed ID: 23633588
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.
    Barthel T; Wollenhaupt J; Lima GMA; Wahl MC; Weiss MS
    J Med Chem; 2022 Nov; 65(21):14630-14641. PubMed ID: 36260741
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography.
    Gelin M; Delfosse V; Allemand F; Hoh F; Sallaz-Damaz Y; Pirocchi M; Bourguet W; Ferrer JL; Labesse G; Guichou JF
    Acta Crystallogr D Biol Crystallogr; 2015 Aug; 71(Pt 8):1777-87. PubMed ID: 26249358
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures.
    Baker LM; Aimon A; Murray JB; Surgenor AE; Matassova N; Roughley SD; Collins PM; Krojer T; von Delft F; Hubbard RE
    Commun Chem; 2020 Sep; 3(1):122. PubMed ID: 36703375
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fragment Hits: What do They Look Like and How do They Bind?
    Giordanetto F; Jin C; Willmore L; Feher M; Shaw DE
    J Med Chem; 2019 Apr; 62(7):3381-3394. PubMed ID: 30875465
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Fragment based drug design: from experimental to computational approaches.
    Kumar A; Voet A; Zhang KY
    Curr Med Chem; 2012; 19(30):5128-47. PubMed ID: 22934764
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Advancing fragment binders to lead-like compounds using ligand and protein-based NMR spectroscopy.
    Maurer T
    Methods Enzymol; 2011; 493():469-85. PubMed ID: 21371602
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lead generation and examples opinion regarding how to follow up hits.
    Orita M; Ohno K; Warizaya M; Amano Y; Niimi T
    Methods Enzymol; 2011; 493():383-419. PubMed ID: 21371599
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study.
    Schiebel J; Radeva N; Krimmer SG; Wang X; Stieler M; Ehrmann FR; Fu K; Metz A; Huschmann FU; Weiss MS; Mueller U; Heine A; Klebe G
    ACS Chem Biol; 2016 Jun; 11(6):1693-701. PubMed ID: 27028906
    [TBL] [Abstract][Full Text] [Related]  

  • 19. FragMAX: the fragment-screening platform at the MAX IV Laboratory.
    Lima GMA; Talibov VO; Jagudin E; Sele C; Nyblom M; Knecht W; Logan DT; Sjögren T; Mueller U
    Acta Crystallogr D Struct Biol; 2020 Aug; 76(Pt 8):771-777. PubMed ID: 32744259
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fragments as Novel Starting Points for tRNA-Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies.
    Hassaan E; Eriksson PO; Geschwindner S; Heine A; Klebe G
    ChemMedChem; 2020 Feb; 15(3):324-337. PubMed ID: 31808981
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.