These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

252 related articles for article (PubMed ID: 34131120)

  • 1. Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses.
    Uyanik B; Goloudina AR; Akbarali A; Grigorash BB; Petukhov AV; Singhal S; Eruslanov E; Chaloyard J; Lagorgette L; Hadi T; Baidyuk EV; Sakai H; Tessarollo L; Ryffel B; Mazur SJ; Lirussi F; Garrido C; Appella E; Demidov ON
    Nat Commun; 2021 Jun; 12(1):3622. PubMed ID: 34131120
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner.
    Esfandiari A; Hawthorne TA; Nakjang S; Lunec J
    Mol Cancer Ther; 2016 Mar; 15(3):379-91. PubMed ID: 26832796
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.
    Pechackova S; Burdova K; Benada J; Kleiblova P; Jenikova G; Macurek L
    Oncotarget; 2016 Mar; 7(12):14458-75. PubMed ID: 26883108
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer.
    Inoue Y; Yamashita N; Kitao H; Tanaka K; Saeki H; Oki E; Oda Y; Tokunaga E; Maehara Y
    Clin Breast Cancer; 2018 Aug; 18(4):e643-e650. PubMed ID: 29275106
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PPM1D is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma.
    Yu Z; Song Y; Cai M; Jiang B; Zhang Z; Wang L; Jiang Y; Zou L; Liu X; Yu N; Mao X; Peng C; Liu S
    Aging (Albany NY); 2021 Sep; 13(17):21294-21308. PubMed ID: 34470916
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
    Nannenga B; Lu X; Dumble M; Van Maanen M; Nguyen TA; Sutton R; Kumar TR; Donehower LA
    Mol Carcinog; 2006 Aug; 45(8):594-604. PubMed ID: 16652371
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine glioma.
    Akamandisa MP; Nie K; Nahta R; Hambardzumyan D; Castellino RC
    Neuro Oncol; 2019 Jun; 21(6):786-799. PubMed ID: 30852603
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of Ser/Thr phosphatase PPM1D induces neutrophil differentiation in HL-60 cells.
    Kamada R; Kudoh F; Yoshimura F; Tanino K; Sakaguchi K
    J Biochem; 2017 Oct; 162(4):303-308. PubMed ID: 28486685
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.
    Sakai H; Fujigaki H; Mazur SJ; Appella E
    Cell Cycle; 2014; 13(6):1015-29. PubMed ID: 24552809
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon.
    Burocziova M; Burdova K; Martinikova AS; Kasparek P; Kleiblova P; Danielsen SA; Borecka M; Jenikova G; Janečková L; Pavel J; Zemankova P; Schneiderova M; Schwarzova L; Ticha I; Sun XF; Jiraskova K; Liska V; Vodickova L; Vodicka P; Sedlacek R; Kleibl Z; Lothe RA; Korinek V; Macurek L
    Cell Death Dis; 2019 Oct; 10(11):818. PubMed ID: 31659152
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy.
    Clausse V; Goloudina AR; Uyanik B; Kochetkova EY; Richaud S; Fedorova OA; Hammann A; Bardou M; Barlev NA; Garrido C; Demidov ON
    Cell Death Dis; 2016 Apr; 7(4):e2195. PubMed ID: 27077811
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.
    Martinikova AS; Burocziova M; Stoyanov M; Macurek L
    Cells; 2020 Sep; 9(9):. PubMed ID: 32927737
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The role of PPM1D in cancer and advances in studies of its inhibitors.
    Deng W; Li J; Dorrah K; Jimenez-Tapia D; Arriaga B; Hao Q; Cao W; Gao Z; Vadgama J; Wu Y
    Biomed Pharmacother; 2020 May; 125():109956. PubMed ID: 32006900
    [TBL] [Abstract][Full Text] [Related]  

  • 14. PPM1D activity promotes cellular transformation by preventing senescence and cell death.
    Stoyanov M; Martinikova AS; Matejkova K; Horackova K; Zemankova P; Burdova K; Zemanova Z; Kleiblova P; Kleibl Z; Macurek L
    Oncogene; 2024 Oct; 43(42):3081-3093. PubMed ID: 39237765
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
    Miller PG; Sperling AS; Mayerhofer C; McConkey ME; Ellegast JM; Da Silva C; Cohen DN; Wang C; Sharda A; Yan N; Saha S; Schluter C; Schechter I; Słabicki M; Sandoval B; Kahn J; Boettcher S; Gibson CJ; Scadden DT; Stegmaier K; Bhatt S; Lindsley RC; Ebert BL
    Blood; 2023 Dec; 142(24):2079-2091. PubMed ID: 37595362
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.
    Kleiblova P; Shaltiel IA; Benada J; Ševčík J; Pecháčková S; Pohlreich P; Voest EE; Dundr P; Bartek J; Kleibl Z; Medema RH; Macurek L
    J Cell Biol; 2013 May; 201(4):511-21. PubMed ID: 23649806
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.
    Lu X; Nguyen TA; Donehower LA
    Cell Cycle; 2005 Aug; 4(8):1060-4. PubMed ID: 15970689
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Silencing of PPM1D inhibits cell proliferation and invasion through the p38 MAPK and p53 signaling pathway in papillary thyroid carcinoma.
    Lu ZW; Wen D; Wei WJ; Han LT; Xiang J; Wang YL; Wang Y; Liao T; Ji QH
    Oncol Rep; 2020 Mar; 43(3):783-794. PubMed ID: 31922231
    [TBL] [Abstract][Full Text] [Related]  

  • 19. TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
    Xu C; Liu H; Pirozzi CJ; Chen LH; Greer PK; Diplas BH; Zhang L; Waitkus MS; He Y; Yan H
    Acta Neuropathol Commun; 2021 Nov; 9(1):178. PubMed ID: 34732238
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.
    Cheeseman MD; Faisal A; Rayter S; Barbeau OR; Kalusa A; Westlake M; Burke R; Swan M; van Montfort R; Linardopoulos S; Jones K
    Bioorg Med Chem Lett; 2014 Aug; 24(15):3469-74. PubMed ID: 24953599
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.