BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 34136078)

  • 1. Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers.
    Sijbesma E; Hallenbeck KK; Andrei SA; Rust RR; Adriaans JMC; Brunsveld L; Arkin MR; Ottmann C
    ACS Med Chem Lett; 2021 Jun; 12(6):976-982. PubMed ID: 34136078
    [TBL] [Abstract][Full Text] [Related]  

  • 2. From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.
    Visser EJ; Jaishankar P; Sijbesma E; Pennings MAM; Vandenboorn EMF; Guillory X; Neitz RJ; Morrow J; Dutta S; Renslo AR; Brunsveld L; Arkin MR; Ottmann C
    Angew Chem Int Ed Engl; 2023 Sep; 62(37):e202308004. PubMed ID: 37455289
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers.
    Sijbesma E; Somsen BA; Miley GP; Leijten-van de Gevel IA; Brunsveld L; Arkin MR; Ottmann C
    ACS Chem Biol; 2020 Dec; 15(12):3143-3148. PubMed ID: 33196173
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
    Sijbesma E; Hallenbeck KK; Leysen S; de Vink PJ; Skóra L; Jahnke W; Brunsveld L; Arkin MR; Ottmann C
    J Am Chem Soc; 2019 Feb; 141(8):3524-3531. PubMed ID: 30707565
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of 14-3-3 PPI Stabilizers by Extension of an Amidine-Substituted Thiophene Fragment.
    Wu Q; Centorrino F; Guillory X; Wolter M; Ottmann C; Cossar PJ; Brunsveld L
    Chembiochem; 2024 Jan; 25(1):e202300636. PubMed ID: 37902676
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.
    Konstantinidou M; Visser EJ; Vandenboorn E; Chen S; Jaishankar P; Overmans M; Dutta S; Neitz RJ; Renslo AR; Ottmann C; Brunsveld L; Arkin MR
    J Am Chem Soc; 2023 Sep; 145(37):20328-20343. PubMed ID: 37676236
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers.
    Kenanova DN; Visser EJ; Virta JM; Sijbesma E; Centorrino F; Vickery HR; Zhong M; Neitz RJ; Brunsveld L; Ottmann C; Arkin MR
    ACS Cent Sci; 2023 May; 9(5):937-946. PubMed ID: 37252362
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.
    Somsen BA; Schellekens RJC; Verhoef CJA; Arkin MR; Ottmann C; Cossar PJ; Brunsveld L
    J Am Chem Soc; 2023 Mar; 145(12):6741-6752. PubMed ID: 36926879
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
    Cossar PJ; Wolter M; van Dijck L; Valenti D; Levy LM; Ottmann C; Brunsveld L
    J Am Chem Soc; 2021 Jun; 143(22):8454-8464. PubMed ID: 34047554
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fragment-based exploration of the 14-3-3/Amot-p130 interface.
    Centorrino F; Andlovic B; Cossar P; Brunsveld L; Ottmann C
    Curr Res Struct Biol; 2022; 4():21-28. PubMed ID: 35036934
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterizing the stabilization effects of stabilizers in protein-protein systems with end-point binding free energy calculations.
    Tang R; Chen P; Wang Z; Wang L; Hao H; Hou T; Sun H
    Brief Bioinform; 2022 May; 23(3):. PubMed ID: 35395683
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering.
    Wolter M; Valenti D; Cossar PJ; Levy LM; Hristeva S; Genski T; Hoffmann T; Brunsveld L; Tzalis D; Ottmann C
    Angew Chem Int Ed Engl; 2020 Nov; 59(48):21520-21524. PubMed ID: 32816380
    [TBL] [Abstract][Full Text] [Related]  

  • 13. What Makes a Good Protein-Protein Interaction Stabilizer: Analysis and Application of the Dual-Binding Mechanism.
    Chen SY; Zacharias M
    ACS Cent Sci; 2023 May; 9(5):969-979. PubMed ID: 37252344
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fragment Screening Yields a Small-Molecule Stabilizer of 14-3-3 Dimers That Modulates Client Protein Interactions.
    Brink HJ; Riemens R; Thee S; Beishuizen B; da Costa Pereira D; Wijtmans M; de Esch I; Smit MJ; de Boer AH
    Chembiochem; 2022 Sep; 23(17):e202200178. PubMed ID: 35767695
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Stabilization of protein-protein interaction complexes through small molecules.
    Zarzycka B; Kuenemann MA; Miteva MA; Nicolaes GAF; Vriend G; Sperandio O
    Drug Discov Today; 2016 Jan; 21(1):48-57. PubMed ID: 26434617
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products.
    Wolter M; de Vink P; Neves JF; Srdanović S; Higuchi Y; Kato N; Wilson A; Landrieu I; Brunsveld L; Ottmann C
    J Am Chem Soc; 2020 Jul; 142(27):11772-11783. PubMed ID: 32501683
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
    Guillory X; Wolter M; Leysen S; Neves JF; Kuusk A; Genet S; Somsen B; Morrow JK; Rivers E; van Beek L; Patel J; Goodnow R; Schoenherr H; Fuller N; Cao Q; Doveston RG; Brunsveld L; Arkin MR; Castaldi P; Boyd H; Landrieu I; Chen H; Ottmann C
    J Med Chem; 2020 Jul; 63(13):6694-6707. PubMed ID: 32501690
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stabilization of protein-protein interactions in drug discovery.
    Andrei SA; Sijbesma E; Hann M; Davis J; O'Mahony G; Perry MWD; Karawajczyk A; Eickhoff J; Brunsveld L; Doveston RG; Milroy LG; Ottmann C
    Expert Opin Drug Discov; 2017 Sep; 12(9):925-940. PubMed ID: 28695752
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Allosteric Modulators of Protein-Protein Interactions (PPIs).
    Ni D; Liu N; Sheng C
    Adv Exp Med Biol; 2019; 1163():313-334. PubMed ID: 31707709
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Probing the Druggablility on the Interface of the Protein-Protein Interaction and Its Allosteric Regulation Mechanism on the Drug Screening for the CXCR4 Homodimer.
    Shen L; Yuan Y; Guo Y; Li M; Li C; Pu X
    Front Pharmacol; 2019; 10():1310. PubMed ID: 31787895
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.