BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

213 related articles for article (PubMed ID: 34142837)

  • 1. Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.
    Gajewiak J; Christensen SB; Dowell C; Hararah F; Fisher F; Huynh PN; Olivera BM; McIntosh JM
    J Med Chem; 2021 Jul; 64(13):9271-9278. PubMed ID: 34142837
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.
    Zheng N; Christensen SB; Dowell C; Purushottam L; Skalicky JJ; McIntosh JM; Chou DH
    J Med Chem; 2021 Jul; 64(13):9513-9524. PubMed ID: 34161094
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues.
    Ellison M; Feng ZP; Park AJ; Zhang X; Olivera BM; McIntosh JM; Norton RS
    J Mol Biol; 2008 Apr; 377(4):1216-27. PubMed ID: 18295795
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models.
    Kryukova EV; Ivanov IA; Lebedev DS; Spirova EN; Egorova NS; Zouridakis M; Kasheverov IE; Tzartos SJ; Tsetlin VI
    Mar Drugs; 2018 Nov; 16(12):. PubMed ID: 30469507
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors.
    Zheng N; Christensen SB; Blakely A; Dowell C; Purushottam L; McIntosh JM; Chou DH
    J Med Chem; 2020 Aug; 63(15):8380-8387. PubMed ID: 32597184
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
    Mohammadi SA; Christie MJ
    Toxins (Basel); 2015 Sep; 7(10):3916-32. PubMed ID: 26426047
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-Activity Studies Reveal the Molecular Basis for GABA
    Sadeghi M; Carstens BB; Callaghan BP; Daniel JT; Tae HS; O'Donnell T; Castro J; Brierley SM; Adams DJ; Craik DJ; Clark RJ
    ACS Chem Biol; 2018 Jun; 13(6):1577-1587. PubMed ID: 29746088
    [TBL] [Abstract][Full Text] [Related]  

  • 8. From Crystal Structures of RgIA4 in Complex with
    Pan S; Fan Y; Zhu X; Xue Y; Luo S; Wang X
    Mar Drugs; 2021 Dec; 19(12):. PubMed ID: 34940708
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and evaluation of disulfide-rich cyclic α-conotoxin [S9A]TxID analogues as novel α3β4 nAChR antagonists.
    Wang S; Ren J; Li R; Li X; Zhangsun D; Wu Y; Luo S
    Bioorg Chem; 2021 Jul; 112():104875. PubMed ID: 33823404
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors.
    Huynh PN; Harvey PJ; Gajewiak J; Craik DJ; Michael McIntosh J
    Biochem Pharmacol; 2020 Nov; 181():114124. PubMed ID: 32593612
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Substitution of D-Arginine at Position 11 of α-RgIA Potently Inhibits α7 Nicotinic Acetylcholine Receptor.
    Wu Y; Zhang J; Ren J; Zhu X; Li R; Zhangsun D; Luo S
    Mar Drugs; 2023 May; 21(6):. PubMed ID: 37367650
    [TBL] [Abstract][Full Text] [Related]  

  • 12. d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability.
    Ren J; Zhu X; Xu P; Li R; Fu Y; Dong S; Zhangsun D; Wu Y; Luo S
    Mar Drugs; 2019 Feb; 17(3):. PubMed ID: 30823399
    [TBL] [Abstract][Full Text] [Related]  

  • 13. αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors.
    Christensen SB; Bandyopadhyay PK; Olivera BM; McIntosh JM
    Biochem Pharmacol; 2015 Aug; 96(4):349-56. PubMed ID: 26074268
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.
    Armishaw CJ; Singh N; Medina-Franco JL; Clark RJ; Scott KC; Houghten RA; Jensen AA
    J Biol Chem; 2010 Jan; 285(3):1809-21. PubMed ID: 19901032
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha9alpha10 nicotinic acetylcholine receptor.
    Halai R; Clark RJ; Nevin ST; Jensen JE; Adams DJ; Craik DJ
    J Biol Chem; 2009 Jul; 284(30):20275-84. PubMed ID: 19447885
    [TBL] [Abstract][Full Text] [Related]  

  • 16. αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.
    Zhangsun D; Zhu X; Kaas Q; Wu Y; Craik DJ; McIntosh JM; Luo S
    Neuropharmacology; 2017 Dec; 127():243-252. PubMed ID: 28416445
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors.
    Tae HS; Gao B; Jin AH; Alewood PF; Adams DJ
    Biochem Pharmacol; 2021 Aug; 190():114638. PubMed ID: 34062129
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-activity studies on alpha-conotoxins.
    Muttenthaler M; Akondi KB; Alewood PF
    Curr Pharm Des; 2011 Dec; 17(38):4226-41. PubMed ID: 22204424
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model.
    AlSharari SD; Toma W; Mahmood HM; Michael McIntosh J; Imad Damaj M
    Eur J Pharmacol; 2020 Sep; 883():173320. PubMed ID: 32645334
    [TBL] [Abstract][Full Text] [Related]  

  • 20. α-Conotoxin Bt1.8 from Conus betulinus selectively inhibits α6/α3β2β3 and α3β2 nicotinic acetylcholine receptor subtypes.
    Ning H; Huang B; Tae HS; Liu Z; Yu S; Li L; Zhang L; Adams DJ; Guo C; Dai Q
    J Neurochem; 2021 Oct; 159(1):90-100. PubMed ID: 34008858
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.