BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

120 related articles for article (PubMed ID: 34146963)

  • 1. Thymidylate synthase is essential for efficient HIV-1 replication in macrophages.
    Desrosiers V; Barat C; Breton Y; Ouellet M; Tremblay MJ
    Virology; 2021 Sep; 561():47-57. PubMed ID: 34146963
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The anticytomegaloviral activity of raltitrexed is abrogated in quiescent mouse fibroblasts that overexpress thymidylate synthase.
    Gribaudo G; Riera L; Lembo D; De Andrea M; Johnson LF; Landolfo S
    Virus Res; 2001 Jan; 73(1):57-65. PubMed ID: 11163644
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme.
    Keyomarsi K; Samet J; Molnar G; Pardee AB
    J Biol Chem; 1993 Jul; 268(20):15142-9. PubMed ID: 8325888
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
    van der Wilt CL; Backus HH; Smid K; Comijn L; Veerman G; Wouters D; Voorn DA; Priest DG; Bunni MA; Mitchell F; Jackman AL; Jansen G; Peters GJ
    Cancer Res; 2001 May; 61(9):3675-81. PubMed ID: 11325838
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages.
    Shepard C; Xu J; Holler J; Kim DH; Mansky LM; Schinazi RF; Kim B
    Retrovirology; 2019 Oct; 16(1):29. PubMed ID: 31655617
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Murine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replication.
    Gribaudo G; Riera L; Lembo D; De Andrea M; Gariglio M; Rudge TL; Johnson LF; Landolfo S
    J Virol; 2000 Jun; 74(11):4979-87. PubMed ID: 10799571
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase.
    Waldman BC; Wang Y; Kilaru K; Yang Z; Bhasin A; Wyatt MD; Waldman AS
    DNA Repair (Amst); 2008 Oct; 7(10):1624-35. PubMed ID: 18603020
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells.
    Dolnick BJ; Lu K; Yin MB; Rustum YM
    Adv Enzyme Regul; 1997; 37():95-109. PubMed ID: 9381988
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
    Farrugia DC; Ford HE; Cunningham D; Danenberg KD; Danenberg PV; Brabender J; McVicar AD; Aherne GW; Hardcastle A; McCarthy K; Jackman AL
    Clin Cancer Res; 2003 Feb; 9(2):792-801. PubMed ID: 12576452
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.
    Tong Y; Liu-Chen X; Ercikan-Abali EA; Zhao SC; Banerjee D; Maley F; Bertino JR
    J Biol Chem; 1998 Nov; 273(47):31209-14. PubMed ID: 9813027
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytosolic sulfotransferase 1A1 regulates HIV-1 minus-strand DNA elongation in primary human monocyte-derived macrophages.
    Swann J; Murry J; Young JA
    Virol J; 2016 Feb; 13():30. PubMed ID: 26906565
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antisense targeting of thymidylate synthase (TS) mRNA increases TS gene transcription and TS protein: effects on human tumor cell sensitivity to TS enzyme-inhibiting drugs.
    Jason TL; Berg RW; Vincent MD; Koropatnick J
    Gene Expr; 2007; 13(4-5):227-39. PubMed ID: 17605297
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach.
    El-Mesallamy HO; El Magdoub HM; Chapman JM; Hamdy NM; Schaalan MF; Hammad LN; Berger SH
    PLoS One; 2018; 13(3):e0193810. PubMed ID: 29538414
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
    Bijnsdorp IV; Comijn EM; Padron JM; Gmeiner WH; Peters GJ
    Oncol Rep; 2007 Jul; 18(1):287-91. PubMed ID: 17549381
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Involvement of base excision repair in response to therapy targeted at thymidylate synthase.
    Li L; Berger SH; Wyatt MD
    Mol Cancer Ther; 2004 Jun; 3(6):747-53. PubMed ID: 15210861
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay.
    Horowitz RW; Zhang H; Schwartz EL; Ladner RD; Wadler S
    Biochem Pharmacol; 1997 Sep; 54(5):635-8. PubMed ID: 9337081
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
    Jackman AL; Kelland LR; Kimbell R; Brown M; Gibson W; Aherne GW; Hardcastle A; Boyle FT
    Br J Cancer; 1995 May; 71(5):914-24. PubMed ID: 7537518
    [TBL] [Abstract][Full Text] [Related]  

  • 18. p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway.
    Allouch A; David A; Amie SM; Lahouassa H; Chartier L; Margottin-Goguet F; Barré-Sinoussi F; Kim B; Sáez-Cirión A; Pancino G
    Proc Natl Acad Sci U S A; 2013 Oct; 110(42):E3997-4006. PubMed ID: 24082141
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells.
    Ferguson PJ; Collins O; Dean NM; DeMoor J; Li CS; Vincent MD; Koropatnick J
    Br J Pharmacol; 1999 Aug; 127(8):1777-86. PubMed ID: 10482907
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
    Aherne GW; Hardcastle A; Raynaud F; Jackman AL
    Biochem Pharmacol; 1996 May; 51(10):1293-301. PubMed ID: 8787544
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.