211 related articles for article (PubMed ID: 34158378)
1. Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma.
Besse L; Besse A; Stolze SC; Sobh A; Zaal EA; van der Ham AJ; Ruiz M; Phuyal S; Büchler L; Sathianathan M; Florea BI; Borén J; Ståhlman M; Huber J; Bolomsky A; Ludwig H; Hannich JT; Loguinov A; Everts B; Berkers CR; Pilon M; Farhan H; Vulpe CD; Overkleeft HS; Driessen C
Cancer Res; 2021 Sep; 81(17):4581-4593. PubMed ID: 34158378
[TBL] [Abstract][Full Text] [Related]
2. Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma.
Besse A; Stolze SC; Rasche L; Weinhold N; Morgan GJ; Kraus M; Bader J; Overkleeft HS; Besse L; Driessen C
Leukemia; 2018 Feb; 32(2):391-401. PubMed ID: 28676669
[TBL] [Abstract][Full Text] [Related]
3. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.
Gills JJ; Lopiccolo J; Tsurutani J; Shoemaker RH; Best CJ; Abu-Asab MS; Borojerdi J; Warfel NA; Gardner ER; Danish M; Hollander MC; Kawabata S; Tsokos M; Figg WD; Steeg PS; Dennis PA
Clin Cancer Res; 2007 Sep; 13(17):5183-94. PubMed ID: 17785575
[TBL] [Abstract][Full Text] [Related]
4. The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo.
Bono C; Karlin L; Harel S; Mouly E; Labaume S; Galicier L; Apcher S; Sauvageon H; Fermand JP; Bories JC; Arnulf B
Haematologica; 2012 Jul; 97(7):1101-9. PubMed ID: 22271897
[TBL] [Abstract][Full Text] [Related]
5. Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08).
Driessen C; Kraus M; Joerger M; Rosing H; Bader J; Hitz F; Berset C; Xyrafas A; Hawle H; Berthod G; Overkleeft HS; Sessa C; Huitema A; Pabst T; von Moos R; Hess D; Mey UJ
Haematologica; 2016 Mar; 101(3):346-55. PubMed ID: 26659919
[TBL] [Abstract][Full Text] [Related]
6. Nelfinavir inhibits human DDI2 and potentiates cytotoxicity of proteasome inhibitors.
Gu Y; Wang X; Wang Y; Wang Y; Li J; Yu FX
Cell Signal; 2020 Nov; 75():109775. PubMed ID: 32916277
[TBL] [Abstract][Full Text] [Related]
7. Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir.
Abt D; Besse A; Sedlarikova L; Kraus M; Bader J; Silzle T; Vodinska M; Slaby O; Schmid HP; Engeler DS; Driessen C; Besse L
BJU Int; 2018 Apr; 121(4):600-609. PubMed ID: 29161753
[TBL] [Abstract][Full Text] [Related]
8. Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.
Fukuda Y; Takenaka K; Sparreboom A; Cheepala SB; Wu CP; Ekins S; Ambudkar SV; Schuetz JD
Mol Pharmacol; 2013 Sep; 84(3):361-71. PubMed ID: 23775562
[TBL] [Abstract][Full Text] [Related]
9. Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations.
Kraus M; Müller-Ide H; Rückrich T; Bader J; Overkleeft H; Driessen C
Leuk Res; 2014 Mar; 38(3):383-92. PubMed ID: 24418752
[TBL] [Abstract][Full Text] [Related]
10. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.
Pyrko P; Kardosh A; Wang W; Xiong W; Schönthal AH; Chen TC
Cancer Res; 2007 Nov; 67(22):10920-8. PubMed ID: 18006837
[TBL] [Abstract][Full Text] [Related]
11. Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis.
Brüning A; Burger P; Vogel M; Rahmeh M; Gingelmaiers A; Friese K; Lenhard M; Burges A
Cancer Biol Ther; 2009 Feb; 8(3):226-32. PubMed ID: 19106637
[TBL] [Abstract][Full Text] [Related]
12. Phospholipids and cholesterol: Inducers of cancer multidrug resistance and therapeutic targets.
Kopecka J; Trouillas P; Gašparović AČ; Gazzano E; Assaraf YG; Riganti C
Drug Resist Updat; 2020 Mar; 49():100670. PubMed ID: 31846838
[TBL] [Abstract][Full Text] [Related]
13. Antitumorigenic action of nelfinavir: Effects on multiple myeloma and hematologic malignancies (Review).
Allegra A; Innao V; Allegra AG; Pulvirenti N; Pugliese M; Musolino C
Oncol Rep; 2020 Jun; 43(6):1729-1736. PubMed ID: 32236596
[TBL] [Abstract][Full Text] [Related]
14. Could the FDA-approved anti-HIV PR inhibitors be promising anticancer agents? An answer from enhanced docking approach and molecular dynamics analyses.
Arodola OA; Soliman ME
Drug Des Devel Ther; 2015; 9():6055-65. PubMed ID: 26622167
[TBL] [Abstract][Full Text] [Related]
15. The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.
Kushchayeva Y; Jensen K; Recupero A; Costello J; Patel A; Klubo-Gwiezdzinska J; Boyle L; Burman K; Vasko V
J Clin Endocrinol Metab; 2014 May; 99(5):E734-45. PubMed ID: 24483157
[TBL] [Abstract][Full Text] [Related]
16. The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response.
Gupta AK; Li B; Cerniglia GJ; Ahmed MS; Hahn SM; Maity A
Neoplasia; 2007 Apr; 9(4):271-8. PubMed ID: 17460771
[TBL] [Abstract][Full Text] [Related]
17. Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate.
Kachko I; Maissel A; Mazor L; Ben-Romano R; Watson RT; Hou JC; Pessin JE; Bashan N; Rudich A
Endocrinology; 2009 Jun; 150(6):2618-26. PubMed ID: 19179444
[TBL] [Abstract][Full Text] [Related]
18. Bortezomib targets the caspase-like proteasome activity in cervical cancer cells, triggering apoptosis that can be enhanced by nelfinavir.
Bruning A; Vogel M; Mylonas I; Friese K; Burges A
Curr Cancer Drug Targets; 2011 Sep; 11(7):799-809. PubMed ID: 21762082
[TBL] [Abstract][Full Text] [Related]
19. Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Okubo K; Isono M; Asano T; Sato A
Anticancer Res; 2018 Oct; 38(10):5615-5626. PubMed ID: 30275179
[TBL] [Abstract][Full Text] [Related]
20. Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.
Shim JS; Rao R; Beebe K; Neckers L; Han I; Nahta R; Liu JO
J Natl Cancer Inst; 2012 Oct; 104(20):1576-90. PubMed ID: 23042933
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
