BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 34161085)

  • 1. A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation.
    Kolla R; Gopinath P; Ricci J; Reif A; Rostami I; Lashuel HA
    J Am Chem Soc; 2021 Jul; 143(26):9798-9812. PubMed ID: 34161085
    [TBL] [Abstract][Full Text] [Related]  

  • 2. N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.
    DeGuire SM; Ruggeri FS; Fares MB; Chiki A; Cendrowska U; Dietler G; Lashuel HA
    J Biol Chem; 2018 Nov; 293(48):18540-18558. PubMed ID: 30185623
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation.
    Vieweg S; Ansaloni A; Wang ZM; Warner JB; Lashuel HA
    J Biol Chem; 2016 Jun; 291(23):12074-86. PubMed ID: 27002149
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy.
    Reif A; Chiki A; Ricci J; Lashuel HA
    J Vis Exp; 2018 Jun; (136):. PubMed ID: 30010666
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease.
    Chen M; Wolynes PG
    Proc Natl Acad Sci U S A; 2017 Apr; 114(17):4406-4411. PubMed ID: 28400517
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington's Disease.
    Wetzel R
    Acc Chem Res; 2020 Oct; 53(10):2347-2357. PubMed ID: 32975927
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT.
    Chongtham A; Bornemann DJ; Barbaro BA; Lukacsovich T; Agrawal N; Syed A; Worthge S; Purcell J; Burke J; Chin TM; Marsh JL
    Hum Mol Genet; 2020 Mar; 29(4):674-688. PubMed ID: 31943010
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The emerging role of the first 17 amino acids of huntingtin in Huntington's disease.
    Arndt JR; Chaibva M; Legleiter J
    Biomol Concepts; 2015 Mar; 6(1):33-46. PubMed ID: 25741791
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.
    Mishra R; Hoop CL; Kodali R; Sahoo B; van der Wel PC; Wetzel R
    J Mol Biol; 2012 Nov; 424(1-2):1-14. PubMed ID: 22999956
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Amplification of neurotoxic HTTex1 assemblies in human neurons.
    Chongtham A; Isas JM; Pandey NK; Rawat A; Yoo JH; Mastro T; Kennedy MB; Langen R; Khoshnan A
    Neurobiol Dis; 2021 Nov; 159():105517. PubMed ID: 34563643
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1.
    Vieweg S; Mahul-Mellier AL; Ruggeri FS; Riguet N; DeGuire SM; Chiki A; Cendrowska U; Dietler G; Lashuel HA
    J Mol Biol; 2021 Oct; 433(21):167222. PubMed ID: 34492254
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.
    Chiki A; DeGuire SM; Ruggeri FS; Sanfelice D; Ansaloni A; Wang ZM; Cendrowska U; Burai R; Vieweg S; Pastore A; Dietler G; Lashuel HA
    Angew Chem Int Ed Engl; 2017 May; 56(19):5202-5207. PubMed ID: 28334491
    [TBL] [Abstract][Full Text] [Related]  

  • 13. N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.
    Chen MZ; Mok SA; Ormsby AR; Muchowski PJ; Hatters DM
    J Huntingtons Dis; 2017; 6(1):79-91. PubMed ID: 28339398
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
    Busch A; Engemann S; Lurz R; Okazawa H; Lehrach H; Wanker EE
    J Biol Chem; 2003 Oct; 278(42):41452-61. PubMed ID: 12888569
    [TBL] [Abstract][Full Text] [Related]  

  • 15. One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease.
    Ansaloni A; Wang ZM; Jeong JS; Ruggeri FS; Dietler G; Lashuel HA
    Angew Chem Int Ed Engl; 2014 Feb; 53(7):1928-33. PubMed ID: 24446188
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis.
    Zheng S; Ghitani N; Blackburn JS; Liu JP; Zeitlin SO
    Mol Brain; 2012 Aug; 5():28. PubMed ID: 22892315
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation.
    Chiki A; Zhang Z; Rajasekhar K; Abriata LA; Rostami I; Krapp LF; Boudeffa D; Dal Peraro M; Lashuel HA
    Front Mol Biosci; 2021; 8():686086. PubMed ID: 34381813
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phosphomimetic Mutations Impact Huntingtin Aggregation in the Presence of a Variety of Lipid Systems.
    Groover SE; Beasley M; Ramamurthy V; Legleiter J
    Biochemistry; 2020 Dec; 59(49):4681-4693. PubMed ID: 33256402
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Aggregation behavior of chemically synthesized, full-length huntingtin exon1.
    Sahoo B; Singer D; Kodali R; Zuchner T; Wetzel R
    Biochemistry; 2014 Jun; 53(24):3897-907. PubMed ID: 24921664
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
    Sahoo B; Arduini I; Drombosky KW; Kodali R; Sanders LH; Greenamyre JT; Wetzel R
    PLoS One; 2016; 11(6):e0155747. PubMed ID: 27271685
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.