BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

226 related articles for article (PubMed ID: 34168128)

  • 1. Residue 6.43 defines receptor function in class F GPCRs.
    Turku A; Schihada H; Kozielewicz P; Bowin CF; Schulte G
    Nat Commun; 2021 Jun; 12(1):3919. PubMed ID: 34168128
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors.
    Zhang X; Dong S; Xu F
    Trends Biochem Sci; 2018 Dec; 43(12):1033-1046. PubMed ID: 30309741
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine.
    Kozielewicz P; Bowin CF; Turku A; Schulte G
    Mol Pharmacol; 2020 Jan; 97(1):23-34. PubMed ID: 31707356
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular Pharmacology of Class F Receptor Activation.
    Kozielewicz P; Turku A; Schulte G
    Mol Pharmacol; 2020 Feb; 97(2):62-71. PubMed ID: 31591260
    [TBL] [Abstract][Full Text] [Related]  

  • 5. WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction.
    Bowin CF; Kozielewicz P; Grätz L; Kowalski-Jahn M; Schihada H; Schulte G
    Sci Signal; 2023 Apr; 16(779):eabo4974. PubMed ID: 37014927
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric G
    Qi X; Liu H; Thompson B; McDonald J; Zhang C; Li X
    Nature; 2019 Jul; 571(7764):279-283. PubMed ID: 31168089
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation mechanism of the human Smoothened receptor.
    Bansal PD; Dutta S; Shukla D
    Biophys J; 2023 Apr; 122(7):1400-1413. PubMed ID: 36883002
    [TBL] [Abstract][Full Text] [Related]  

  • 8. FZD
    Wright SC; Cañizal MCA; Benkel T; Simon K; Le Gouill C; Matricon P; Namkung Y; Lukasheva V; König GM; Laporte SA; Carlsson J; Kostenis E; Bouvier M; Schulte G; Hoffmann C
    Sci Signal; 2018 Dec; 11(559):. PubMed ID: 30514810
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The tyrosine Y250
    Strakova K; Matricon P; Yokota C; Arthofer E; Bernatik O; Rodriguez D; Arenas E; Carlsson J; Bryja V; Schulte G
    Cell Signal; 2017 Oct; 38():85-96. PubMed ID: 28668722
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure of the Frizzled 4 receptor in a ligand-free state.
    Yang S; Wu Y; Xu TH; de Waal PW; He Y; Pu M; Chen Y; DeBruine ZJ; Zhang B; Zaidi SA; Popov P; Guo Y; Han GW; Lu Y; Suino-Powell K; Dong S; Harikumar KG; Miller LJ; Katritch V; Xu HE; Shui W; Stevens RC; Melcher K; Zhao S; Xu F
    Nature; 2018 Aug; 560(7720):666-670. PubMed ID: 30135577
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.
    Hedger G; Koldsø H; Chavent M; Siebold C; Rohatgi R; Sansom MSP
    Structure; 2019 Mar; 27(3):549-559.e2. PubMed ID: 30595453
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
    Qi X; Friedberg L; De Bose-Boyd R; Long T; Li X
    Nat Chem Biol; 2020 Dec; 16(12):1368-1375. PubMed ID: 32929279
    [TBL] [Abstract][Full Text] [Related]  

  • 13. WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3.
    Dijksterhuis JP; Petersen J; Schulte G
    Br J Pharmacol; 2014 Mar; 171(5):1195-209. PubMed ID: 24032637
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Multiscale simulations on human Frizzled and Taste2 GPCRs.
    Alfonso-Prieto M; Giorgetti A; Carloni P
    Curr Opin Struct Biol; 2019 Apr; 55():8-16. PubMed ID: 30933747
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.
    Grätz L; Kowalski-Jahn M; Scharf MM; Kozielewicz P; Jahn M; Bous J; Lambert NA; Gloriam DE; Schulte G
    Nat Commun; 2023 Jul; 14(1):4573. PubMed ID: 37516754
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.
    Valnohova J; Kowalski-Jahn M; Sunahara RK; Schulte G
    J Biol Chem; 2018 Nov; 293(46):17875-17887. PubMed ID: 30237173
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular modeling study on the dynamical structural features of human smoothened receptor and binding mechanism of antagonist LY2940680 by metadynamics simulation and free energy calculation.
    Bai Q; Shen Y; Jin N; Liu H; Yao X
    Biochim Biophys Acta; 2014 Jul; 1840(7):2128-38. PubMed ID: 24637074
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics.
    Schulte G
    Eur J Pharmacol; 2015 Sep; 763(Pt B):191-5. PubMed ID: 26003275
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Frizzleds act as dynamic pharmacological entities.
    Schulte G; Scharf MM; Bous J; Voss JH; Grätz L; Kozielewicz P
    Trends Pharmacol Sci; 2024 May; 45(5):419-429. PubMed ID: 38594145
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Molecular basis of drug resistance in smoothened receptor: An in silico study of protein resistivity and specificity.
    Sinha N; Chowdhury S; Sarkar RR
    Proteins; 2020 Mar; 88(3):514-526. PubMed ID: 31589795
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.