247 related articles for article (PubMed ID: 34174329)
1. The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer.
Kabra A; Bushweller J
J Mol Biol; 2022 Jan; 434(1):167117. PubMed ID: 34174329
[TBL] [Abstract][Full Text] [Related]
2. Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors.
Yang Y; Ahmad E; Premkumar V; Liu A; Ashikur Rahman SM; Nikolovska-Coleska Z
Protein Sci; 2024 Jun; 33(6):e5019. PubMed ID: 38747396
[TBL] [Abstract][Full Text] [Related]
3. The YEATS domain epigenetic reader proteins ENL and AF9 and their therapeutic value in leukemia.
Hu H; Muntean AG
Exp Hematol; 2023 Aug; 124():15-21. PubMed ID: 37295550
[TBL] [Abstract][Full Text] [Related]
4. Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth.
Wu F; Nie S; Yao Y; Huo T; Li X; Wu X; Zhao J; Lin YL; Zhang Y; Mo Q; Song Y
Theranostics; 2021; 11(17):8172-8184. PubMed ID: 34373735
[TBL] [Abstract][Full Text] [Related]
5. Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9.
Christott T; Bennett J; Coxon C; Monteiro O; Giroud C; Beke V; Felce SL; Gamble V; Gileadi C; Poda G; Al-Awar R; Farnie G; Fedorov O
SLAS Discov; 2019 Feb; 24(2):133-141. PubMed ID: 30359161
[TBL] [Abstract][Full Text] [Related]
6. Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity.
Ui A; Yasui A
Nucleus; 2016 Apr; 7(2):138-45. PubMed ID: 27310306
[TBL] [Abstract][Full Text] [Related]
7. ENL: structure, function, and roles in hematopoiesis and acute myeloid leukemia.
Zhou J; Ng Y; Chng WJ
Cell Mol Life Sci; 2018 Nov; 75(21):3931-3941. PubMed ID: 30066088
[TBL] [Abstract][Full Text] [Related]
8. MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.
Perlman EJ; Gadd S; Arold ST; Radhakrishnan A; Gerhard DS; Jennings L; Huff V; Guidry Auvil JM; Davidsen TM; Dome JS; Meerzaman D; Hsu CH; Nguyen C; Anderson J; Ma Y; Mungall AJ; Moore RA; Marra MA; Mullighan CG; Ma J; Wheeler DA; Hampton OA; Gastier-Foster JM; Ross N; Smith MA
Nat Commun; 2015 Dec; 6():10013. PubMed ID: 26635203
[TBL] [Abstract][Full Text] [Related]
9. A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.
Mueller D; Bach C; Zeisig D; Garcia-Cuellar MP; Monroe S; Sreekumar A; Zhou R; Nesvizhskii A; Chinnaiyan A; Hess JL; Slany RK
Blood; 2007 Dec; 110(13):4445-54. PubMed ID: 17855633
[TBL] [Abstract][Full Text] [Related]
10. Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins.
Shen C; Jo SY; Liao C; Hess JL; Nikolovska-Coleska Z
J Biol Chem; 2013 Oct; 288(42):30585-30596. PubMed ID: 23996074
[TBL] [Abstract][Full Text] [Related]
11. Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.
Leach BI; Kuntimaddi A; Schmidt CR; Cierpicki T; Johnson SA; Bushweller JH
Structure; 2013 Jan; 21(1):176-183. PubMed ID: 23260655
[TBL] [Abstract][Full Text] [Related]
12. The leukemia-associated gene Mllt1/ENL: characterization of a murine homolog and demonstration of an essential role in embryonic development.
Doty RT; Vanasse GJ; Disteche CM; Willerford DM
Blood Cells Mol Dis; 2002; 28(3):407-17. PubMed ID: 12367585
[TBL] [Abstract][Full Text] [Related]
13. Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Moustakim M; Christott T; Monteiro OP; Bennett J; Giroud C; Ward J; Rogers CM; Smith P; Panagakou I; Díaz-Sáez L; Felce SL; Gamble V; Gileadi C; Halidi N; Heidenreich D; Chaikuad A; Knapp S; Huber KVM; Farnie G; Heer J; Manevski N; Poda G; Al-Awar R; Dixon DJ; Brennan PE; Fedorov O
Angew Chem Int Ed Engl; 2018 Dec; 57(50):16302-16307. PubMed ID: 30288907
[TBL] [Abstract][Full Text] [Related]
14. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Raux B; Buchan KA; Bennett J; Christott T; Dowling MS; Farnie G; Fedorov O; Gamble V; Gileadi C; Giroud C; Huber KVM; Korczynska M; Limberakis C; Narayanan A; Owen DR; Sáez LD; Stock IA; Londregan AT
Bioorg Med Chem Lett; 2024 Jan; 98():129546. PubMed ID: 37944866
[TBL] [Abstract][Full Text] [Related]
15. SIRT2 regulates proliferation and chemotherapy response of MLL-ENL-driven acute myeloid leukemia.
Hao C; Shao X; Song J; Peng M; Lao Y; Mack R; Zhang L; Wei W; Liu N; Wang T; Wu Y; Feng L; Yin L; Wang S; Sun X; Chen S; Zhang J; Li B
Biochem Biophys Res Commun; 2022 Mar; 596():36-42. PubMed ID: 35108652
[TBL] [Abstract][Full Text] [Related]
16. Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.
He N; Chan CK; Sobhian B; Chou S; Xue Y; Liu M; Alber T; Benkirane M; Zhou Q
Proc Natl Acad Sci U S A; 2011 Sep; 108(36):E636-45. PubMed ID: 21873227
[TBL] [Abstract][Full Text] [Related]
17. BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity.
Schmidt CR; Achille NJ; Kuntimaddi A; Boulton AM; Leach BI; Zhang S; Zeleznik-Le NJ; Bushweller JH
Blood Cancer Discov; 2020 Sep; 1(2):162-177. PubMed ID: 32954361
[TBL] [Abstract][Full Text] [Related]
18. The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia.
Hu H; Saha N; Yang Y; Ahmad E; Lachowski L; Shrestha U; Premkumar V; Ropa J; Chen L; Teahan B; Grigsby S; Marschalek R; Nikolovska-Coleska Z; Muntean AG
Leukemia; 2023 Jan; 37(1):190-201. PubMed ID: 36435883
[TBL] [Abstract][Full Text] [Related]
19. YEATS domain proteins: a diverse family with many links to chromatin modification and transcription.
Schulze JM; Wang AY; Kobor MS
Biochem Cell Biol; 2009 Feb; 87(1):65-75. PubMed ID: 19234524
[TBL] [Abstract][Full Text] [Related]
20. MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.
Monroe SC; Jo SY; Sanders DS; Basrur V; Elenitoba-Johnson KS; Slany RK; Hess JL
Exp Hematol; 2011 Jan; 39(1):77-86.e1-5. PubMed ID: 20854876
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
