These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 34226276)

  • 21. Loss of the DNA repair protein, polynucleotide kinase/phosphatase, activates the type 1 interferon response independent of ionizing radiation.
    Kate WD; Fanta M; Weinfeld M
    Nucleic Acids Res; 2024 Sep; 52(16):9630-9653. PubMed ID: 39087523
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage.
    Jilani A; Ramotar D; Slack C; Ong C; Yang XM; Scherer SW; Lasko DD
    J Biol Chem; 1999 Aug; 274(34):24176-86. PubMed ID: 10446192
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites.
    Della-Maria J; Hegde ML; McNeill DR; Matsumoto Y; Tsai MS; Ellenberger T; Wilson DM; Mitra S; Tomkinson AE
    J Biol Chem; 2012 Nov; 287(46):39233-44. PubMed ID: 22992732
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Functional analysis of a conserved site mutation in the DNA end processing enzyme PNKP leading to ataxia with oculomotor apraxia type 4 in humans.
    Islam A; Chakraborty A; Gambardella S; Campopiano R; Sarker AH; Boldogh I; Hazra T
    J Biol Chem; 2023 May; 299(5):104714. PubMed ID: 37061005
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
    Chakraborty A; Tapryal N; Venkova T; Mitra J; Vasquez V; Sarker AH; Duarte-Silva S; Huai W; Ashizawa T; Ghosh G; Maciel P; Sarkar PS; Hegde ML; Chen X; Hazra TK
    Proc Natl Acad Sci U S A; 2020 Apr; 117(14):8154-8165. PubMed ID: 32205441
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Genetic screening for synthetic lethal partners of polynucleotide kinase/phosphatase: potential for targeting SHP-1-depleted cancers.
    Mereniuk TR; Maranchuk RA; Schindler A; Penner-Chea J; Freschauf GK; Hegazy S; Lai R; Foley E; Weinfeld M
    Cancer Res; 2012 Nov; 72(22):5934-44. PubMed ID: 22962271
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Changes in characteristics of murine hair follicles and tissue stem cells by aging.
    Sugaya K
    Mech Dev; 2020 Sep; 163():103630. PubMed ID: 32645346
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Domain analysis of PNKP-XRCC1 interactions: Influence of genetic variants of XRCC1.
    Mani RS; Mermershtain I; Abdou I; Fanta M; Hendzel MJ; Glover JNM; Weinfeld M
    J Biol Chem; 2019 Jan; 294(2):520-530. PubMed ID: 30446622
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Mutations in PNKP cause microcephaly, seizures and defects in DNA repair.
    Shen J; Gilmore EC; Marshall CA; Haddadin M; Reynolds JJ; Eyaid W; Bodell A; Barry B; Gleason D; Allen K; Ganesh VS; Chang BS; Grix A; Hill RS; Topcu M; Caldecott KW; Barkovich AJ; Walsh CA
    Nat Genet; 2010 Mar; 42(3):245-9. PubMed ID: 20118933
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
    Coquelle N; Havali-Shahriari Z; Bernstein N; Green R; Glover JN
    Proc Natl Acad Sci U S A; 2011 Dec; 108(52):21022-7. PubMed ID: 22171004
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair.
    Tahbaz N; Subedi S; Weinfeld M
    Nucleic Acids Res; 2012 Apr; 40(8):3484-95. PubMed ID: 22210862
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Nanoencapsulation of Novel Inhibitors of PNKP for Selective Sensitization to Ionizing Radiation and Irinotecan and Induction of Synthetic Lethality.
    Shire Z; Vakili MR; Morgan TDR; Hall DG; Lavasanifar A; Weinfeld M
    Mol Pharm; 2018 Jun; 15(6):2316-2326. PubMed ID: 29688721
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The Phenotypic Spectrum of PNKP-Associated Disease and the Absence of Immunodeficiency and Cancer Predisposition in a Dutch Cohort.
    Garrelfs MR; Takada S; Kamsteeg EJ; Pegge S; Mancini G; Engelen M; van de Warrenburg B; Rennings A; van Gaalen J; Peters I; Weemaes C; van der Burg M; Willemsen MA
    Pediatr Neurol; 2020 Dec; 113():26-32. PubMed ID: 32980744
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.
    Sanchez A; Gadaleta MC; Limbo O; Russell P
    PLoS Genet; 2017 Sep; 13(9):e1007013. PubMed ID: 28922417
    [TBL] [Abstract][Full Text] [Related]  

  • 35. DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation.
    Ma X; Han Y; Song X; Do T; Yang Z; Ni J; Xie T
    Development; 2016 Dec; 143(23):4312-4323. PubMed ID: 27729408
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Differential response of epithelial stem cell populations in hair follicles to TGF-β signaling.
    Lin HY; Yang LT
    Dev Biol; 2013 Jan; 373(2):394-406. PubMed ID: 23103542
    [TBL] [Abstract][Full Text] [Related]  

  • 37. A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer.
    Sadat SMA; Paiva IM; Shire Z; Sanaee F; Morgan TDR; Paladino M; Karimi-Busheri F; Mani RS; Martin GR; Jirik FR; Hall DG; Weinfeld M; Lavasanifar A
    J Control Release; 2021 Jun; 334():335-352. PubMed ID: 33933518
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
    Gao R; Chakraborty A; Geater C; Pradhan S; Gordon KL; Snowden J; Yuan S; Dickey AS; Choudhary S; Ashizawa T; Ellerby LM; La Spada AR; Thompson LM; Hazra TK; Sarkar PS
    Elife; 2019 Apr; 8():. PubMed ID: 30994454
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery of potential inhibitors targeting the kinase domain of polynucleotide kinase/phosphatase (PNKP): Homology modeling, virtual screening based on multiple conformations, and molecular dynamics simulation.
    Zhu J; Zhang H; Jia L; Ma L; Xu L; Chen Y; Cai Y; Li H; Huang G; Jin J
    Comput Biol Chem; 2021 Oct; 94():107517. PubMed ID: 34456161
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Independent mechanisms of stimulation of polynucleotide kinase/phosphatase by phosphorylated and non-phosphorylated XRCC1.
    Lu M; Mani RS; Karimi-Busheri F; Fanta M; Wang H; Litchfeld DW; Weinfeld M
    Nucleic Acids Res; 2010 Jan; 38(2):510-21. PubMed ID: 19910369
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.