BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

238 related articles for article (PubMed ID: 34239038)

  • 1. Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.
    Galaz-Montoya JG; Shahmoradian SH; Shen K; Frydman J; Chiu W
    Commun Biol; 2021 Jul; 4(1):849. PubMed ID: 34239038
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.
    Darrow MC; Sergeeva OA; Isas JM; Galaz-Montoya JG; King JA; Langen R; Schmid MF; Chiu W
    J Biol Chem; 2015 Jul; 290(28):17451-61. PubMed ID: 25995452
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural insight into transmissive mutant huntingtin species by correlative light and electron microscopy and cryo-electron tomography.
    Kuang X; Nunn K; Jiang J; Castellano P; Hardikar U; Horgan A; Kong J; Tan Z; Dai W
    Biochem Biophys Res Commun; 2021 Jun; 560():99-104. PubMed ID: 33984771
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural insights into the aggregation mechanism of huntingtin exon 1 protein fragment with different polyQ-lengths.
    Priya SB; Gromiha MM
    J Cell Biochem; 2019 Jun; 120(6):10519-10529. PubMed ID: 30672003
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington's disease.
    Chen M; Wolynes PG
    Proc Natl Acad Sci U S A; 2017 Apr; 114(17):4406-4411. PubMed ID: 28400517
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Autophagy preferentially degrades non-fibrillar polyQ aggregates.
    Zhao DY; Bäuerlein FJB; Saha I; Hartl FU; Baumeister W; Wilfling F
    Mol Cell; 2024 May; 84(10):1980-1994.e8. PubMed ID: 38759629
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT.
    Chongtham A; Bornemann DJ; Barbaro BA; Lukacsovich T; Agrawal N; Syed A; Worthge S; Purcell J; Burke J; Chin TM; Marsh JL
    Hum Mol Genet; 2020 Mar; 29(4):674-688. PubMed ID: 31943010
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Polyglutamine tracts regulate beclin 1-dependent autophagy.
    Ashkenazi A; Bento CF; Ricketts T; Vicinanza M; Siddiqi F; Pavel M; Squitieri F; Hardenberg MC; Imarisio S; Menzies FM; Rubinsztein DC
    Nature; 2017 May; 545(7652):108-111. PubMed ID: 28445460
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy.
    Carbo M; Brandi V; Pascarella G; Staid DS; Colotti G; Polticelli F; Ilari A; Morea V
    Int J Mol Med; 2019 Dec; 44(6):2223-2233. PubMed ID: 31638189
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.
    Peskett TR; Rau F; O'Driscoll J; Patani R; Lowe AR; Saibil HR
    Mol Cell; 2018 May; 70(4):588-601.e6. PubMed ID: 29754822
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conformation-dependent recognition of mutant HTT (huntingtin) proteins by selective autophagy.
    Sun X; Fu Y; Pan Y; Lu B
    Autophagy; 2017; 13(12):2111-2112. PubMed ID: 28976800
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Searching for Correlations Between the Development of Neurodegenerative Hallmarks: Targeting Huntingtin as a Contributing Factor.
    Angelova NP
    Adv Exp Med Biol; 2017; 987():269-281. PubMed ID: 28971465
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphomimetic Mutations Impact Huntingtin Aggregation in the Presence of a Variety of Lipid Systems.
    Groover SE; Beasley M; Ramamurthy V; Legleiter J
    Biochemistry; 2020 Dec; 59(49):4681-4693. PubMed ID: 33256402
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions.
    Davranche A; Aviolat H; Zeder-Lutz G; Busso D; Altschuh D; Trottier Y; Klein FA
    Hum Mol Genet; 2011 Jul; 20(14):2795-806. PubMed ID: 21518730
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils.
    Isas JM; Langen A; Isas MC; Pandey NK; Siemer AB
    Biochemistry; 2017 Jul; 56(28):3579-3586. PubMed ID: 28621522
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
    Liu L; Prime ME; Lee MR; Khetarpal V; Brown CJ; Johnson PD; Miranda-Azpiazu P; Chen X; Clark-Frew D; Coe S; Davis R; Dickie A; Ebneth A; Esposito S; Gadouleau E; Gai X; Galan S; Green S; Greenaway C; Giles P; Halldin C; Hayes S; Herbst T; Herrmann F; Heßmann M; Jia Z; Kiselyov A; Kotey A; Krulle T; Mangette JE; Marston RW; Menta S; Mills MR; Monteagudo E; Nag S; Nibbio M; Orsatti L; Schaertl S; Scheich C; Sproston J; Stepanov V; Svedberg M; Takano A; Taylor M; Thomas W; Toth M; Vaidya D; Vanräs K; Weddell D; Wigginton I; Wityak J; Mrzljak L; Munoz-Sanjuan I; Bard JA; Dominguez C
    J Med Chem; 2020 Aug; 63(15):8608-8633. PubMed ID: 32662649
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.
    Shen K; Calamini B; Fauerbach JA; Ma B; Shahmoradian SH; Serrano Lachapel IL; Chiu W; Lo DC; Frydman J
    Elife; 2016 Oct; 5():. PubMed ID: 27751235
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model.
    van Hagen M; Piebes DGE; de Leeuw WC; Vuist IM; van Roon-Mom WMC; Moerland PD; Verschure PJ
    BMC Genomics; 2017 May; 18(1):373. PubMed ID: 28499347
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples.
    Ast A; Schindler F; Buntru A; Schnoegl S; Wanker EE
    Methods Mol Biol; 2018; 1780():31-40. PubMed ID: 29856013
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington's disease.
    Norrbacka S; Lindholm D; Myöhänen TT
    J Cell Mol Med; 2019 Dec; 23(12):8511-8515. PubMed ID: 31565846
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 12.