BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 34241941)

  • 1. Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099, in a xenograft mouse model of canine histiocytic sarcoma.
    Tani H; Miyamoto R; Nagashima T; Michishita M; Tamura K; Bonkobara M
    Vet Comp Oncol; 2022 Mar; 20(1):109-117. PubMed ID: 34241941
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099.
    Tani H; Kurita S; Miyamoto R; Ochiai K; Tamura K; Bonkobara M
    Vet Comp Oncol; 2020 Jun; 18(2):161-168. PubMed ID: 31339650
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PTPN11 mutations in canine and human disseminated histiocytic sarcoma.
    Hédan B; Rault M; Abadie J; Ulvé R; Botherel N; Devauchelle P; Copie-Bergman C; Cadieu E; Parrens M; Alten J; Zalcman EL; Cario G; Damaj G; Mokhtari K; Le Loarer F; Coulomb-Lhermine A; Derrien T; Hitte C; Bachelot L; Breen M; Gilot D; Blay JY; Donadieu J; André C
    Int J Cancer; 2020 Sep; 147(6):1657-1665. PubMed ID: 32212266
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2.
    Ito K; Miyamoto R; Tani H; Kurita S; Kobayashi M; Tamura K; Bonkobara M
    J Vet Pharmacol Ther; 2018 Feb; 41(1):e45-e48. PubMed ID: 28833247
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Gain-of-function mutation in PTPN11 in histiocytic sarcomas of Bernese Mountain Dogs.
    Thaiwong T; Sirivisoot S; Takada M; Yuzbasiyan-Gurkan V; Kiupel M
    Vet Comp Oncol; 2018 Jun; 16(2):220-228. PubMed ID: 28929581
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.
    LaRochelle JR; Fodor M; Vemulapalli V; Mohseni M; Wang P; Stams T; LaMarche MJ; Chopra R; Acker MG; Blacklow SC
    Nat Commun; 2018 Oct; 9(1):4508. PubMed ID: 30375388
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
    Chen YN; LaMarche MJ; Chan HM; Fekkes P; Garcia-Fortanet J; Acker MG; Antonakos B; Chen CH; Chen Z; Cooke VG; Dobson JR; Deng Z; Fei F; Firestone B; Fodor M; Fridrich C; Gao H; Grunenfelder D; Hao HX; Jacob J; Ho S; Hsiao K; Kang ZB; Karki R; Kato M; Larrow J; La Bonte LR; Lenoir F; Liu G; Liu S; Majumdar D; Meyer MJ; Palermo M; Perez L; Pu M; Price E; Quinn C; Shakya S; Shultz MD; Slisz J; Venkatesan K; Wang P; Warmuth M; Williams S; Yang G; Yuan J; Zhang JH; Zhu P; Ramsey T; Keen NJ; Sellers WR; Stams T; Fortin PD
    Nature; 2016 Jul; 535(7610):148-52. PubMed ID: 27362227
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2
    Du S; Lu XH; Li WY; Li LP; Ma YC; Zhou L; Wu JW; Ma Y; Wang RL
    Mol Divers; 2021 Aug; 25(3):1873-1887. PubMed ID: 33392964
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of an Orthotopic Intrasplenic Xenograft Mouse Model of Canine Histiocytic Sarcoma and Its Use in Evaluating the Efficacy of Treatment with Dasatinib.
    Takada M; Smyth LA; Hix JM; Corner SM; Kiupel M; Yuzbasiyan-Gurkan V
    Comp Med; 2019 Feb; 69(1):22-28. PubMed ID: 30717820
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of the drug sensitivity and expression of 16 drug resistance-related genes in canine histiocytic sarcoma cell lines.
    Asada H; Tomiyasu H; Goto-Koshino Y; Fujino Y; Ohno K; Tsujimoto H
    J Vet Med Sci; 2015 Jun; 77(6):677-84. PubMed ID: 25715778
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Activating Mutations in
    Takada M; Smyth LA; Thaiwong T; Richter M; Corner SM; Schall PZ; Kiupel M; Yuzbasiyan-Gurkan V
    Genes (Basel); 2019 Jul; 10(7):. PubMed ID: 31277422
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Establishment and characterisation of cell lines and xenograft mouse models of canine systemic histiocytosis and disseminated histiocytic sarcoma.
    Hirabayashi M; Chambers JK; Kishimoto TE; Nguyen SV; Ishikawa Y; Rimpo K; Nakayama H; Uchida K
    Vet Comp Oncol; 2022 Jun; 20(2):465-475. PubMed ID: 34907644
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma.
    Asada H; Tsuboi M; Chambers JK; Uchida K; Tomiyasu H; Goto-Koshino Y; Ohno K; Tsujimoto H
    J Vet Med Sci; 2017 Oct; 79(10):1721-1726. PubMed ID: 28867679
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma.
    Asada H; Tomiyasu H; Okada K; Chambers JK; Goto-Koshino Y; Uchida K; Kagawa Y; Ohno K; Tsujimoto H
    Res Vet Sci; 2019 Jun; 124():57-60. PubMed ID: 30852355
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers.
    Hao HX; Wang H; Liu C; Kovats S; Velazquez R; Lu H; Pant B; Shirley M; Meyer MJ; Pu M; Lim J; Fleming M; Alexander L; Farsidjani A; LaMarche MJ; Moody S; Silver SJ; Caponigro G; Stuart DD; Abrams TJ; Hammerman PS; Williams J; Engelman JA; Goldoni S; Mohseni M
    Mol Cancer Ther; 2019 Dec; 18(12):2368-2380. PubMed ID: 31439712
    [No Abstract]   [Full Text] [Related]  

  • 16. Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells.
    Ito K; Kuroki S; Kobayashi M; Ono K; Washizu T; Bonkobara M
    Vet J; 2013 Jun; 196(3):536-40. PubMed ID: 23369384
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Survivin suppressor (YM155) enhances chemotherapeutic efficacy against canine histiocytic sarcoma in murine transplantation models.
    Yamazaki H; Takagi S; Hosoya K; Okumura M
    Res Vet Sci; 2015 Apr; 99():137-44. PubMed ID: 25744435
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies.
    Takada M; Parys M; Gregory-Bryson E; Vilar Saavedra P; Kiupel M; Yuzbasiyan-Gurkan V
    BMC Cancer; 2018 Mar; 18(1):237. PubMed ID: 29490634
    [TBL] [Abstract][Full Text] [Related]  

  • 19. mRNA sequencing analysis and growth inhibitory effects of palbociclib on cell lines from canine histiocytic proliferative disorders.
    Hirabayashi M; Chambers JK; Tani A; Tomiyasu H; Motegi T; Rimpo K; Nakayama H; Uchida K
    Vet Comp Oncol; 2022 Sep; 20(3):587-601. PubMed ID: 35278028
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma.
    Asada H; Ichii O; Tomiyasu H; Uchida K; Chambers JK; Goto-Koshino Y; Ohno K; Kon Y; Tsujimoto H
    J Vet Med Sci; 2019 Mar; 81(3):353-356. PubMed ID: 30662044
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.