154 related articles for article (PubMed ID: 34267879)
1. Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.
Hayashi K; Uehara S; Yamamoto S; Cary DR; Nishikawa J; Ueda T; Ozasa H; Mihara K; Yoshimura N; Kawai T; Ono T; Yamamoto S; Fumoto M; Mikamiyama H
ACS Med Chem Lett; 2021 Jul; 12(7):1093-1101. PubMed ID: 34267879
[TBL] [Abstract][Full Text] [Related]
2. Macrocyclic peptides as allosteric inhibitors of nicotinamide
van Haren MJ; Zhang Y; Thijssen V; Buijs N; Gao Y; Mateuszuk L; Fedak FA; Kij A; Campagna R; Sartini D; Emanuelli M; Chlopicki S; Jongkees SAK; Martin NI
RSC Chem Biol; 2021 Oct; 2(5):1546-1555. PubMed ID: 34704059
[TBL] [Abstract][Full Text] [Related]
3. Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ.
Lee HY; Suciu RM; Horning BD; Vinogradova EV; Ulanovskaya OA; Cravatt BF
Bioorg Med Chem Lett; 2018 Sep; 28(16):2682-2687. PubMed ID: 29731364
[TBL] [Abstract][Full Text] [Related]
4. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase.
Neelakantan H; Wang HY; Vance V; Hommel JD; McHardy SF; Watowich SJ
J Med Chem; 2017 Jun; 60(12):5015-5028. PubMed ID: 28548833
[TBL] [Abstract][Full Text] [Related]
5. High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide
Policarpo RL; Decultot L; May E; Kuzmič P; Carlson S; Huang D; Chu V; Wright BA; Dhakshinamoorthy S; Kannt A; Rani S; Dittakavi S; Panarese JD; Gaudet R; Shair MD
J Med Chem; 2019 Nov; 62(21):9837-9873. PubMed ID: 31589440
[TBL] [Abstract][Full Text] [Related]
6. Bisubstrate Inhibitors of Nicotinamide
Gao Y; van Haren MJ; Moret EE; Rood JJM; Sartini D; Salvucci A; Emanuelli M; Craveur P; Babault N; Jin J; Martin NI
J Med Chem; 2019 Jul; 62(14):6597-6614. PubMed ID: 31265285
[TBL] [Abstract][Full Text] [Related]
7. Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).
Babault N; Allali-Hassani A; Li F; Fan J; Yue A; Ju K; Liu F; Vedadi M; Liu J; Jin J
J Med Chem; 2018 Feb; 61(4):1541-1551. PubMed ID: 29320176
[TBL] [Abstract][Full Text] [Related]
8. Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase Activity.
Neelakantan H; Vance V; Wang HL; McHardy SF; Watowich SJ
Biochemistry; 2017 Feb; 56(6):824-832. PubMed ID: 28121423
[TBL] [Abstract][Full Text] [Related]
9. A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase.
van Haren MJ; Sastre Toraño J; Sartini D; Emanuelli M; Parsons RB; Martin NI
Biochemistry; 2016 Sep; 55(37):5307-15. PubMed ID: 27570878
[TBL] [Abstract][Full Text] [Related]
10. Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state.
van Haren MJ; Taig R; Kuppens J; Sastre Toraño J; Moret EE; Parsons RB; Sartini D; Emanuelli M; Martin NI
Org Biomol Chem; 2017 Aug; 15(31):6656-6667. PubMed ID: 28758655
[TBL] [Abstract][Full Text] [Related]
11. Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target.
Gao Y; Martin NI; van Haren MJ
Drug Discov Today; 2021 Nov; 26(11):2699-2706. PubMed ID: 34029690
[TBL] [Abstract][Full Text] [Related]
12. Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase.
Iyamu ID; Huang R
Anal Biochem; 2020 Sep; 604():113833. PubMed ID: 32622979
[TBL] [Abstract][Full Text] [Related]
13. The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition.
van Haren MJ; Thomas MG; Sartini D; Barlow DJ; Ramsden DB; Emanuelli M; Klamt F; Martin NI; Parsons RB
Int J Biochem Cell Biol; 2018 May; 98():127-136. PubMed ID: 29549048
[TBL] [Abstract][Full Text] [Related]
14. Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation.
Roberti A; Fernández AF; Fraga MF
Mol Metab; 2021 Mar; 45():101165. PubMed ID: 33453420
[TBL] [Abstract][Full Text] [Related]
15. Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides.
Yoshida S; Uehara S; Kondo N; Takahashi Y; Yamamoto S; Kameda A; Kawagoe S; Inoue N; Yamada M; Yoshimura N; Tachibana Y
J Med Chem; 2022 Aug; 65(15):10655-10673. PubMed ID: 35904556
[TBL] [Abstract][Full Text] [Related]
16. Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.
Aksoy S; Szumlanski CL; Weinshilboum RM
J Biol Chem; 1994 May; 269(20):14835-40. PubMed ID: 8182091
[TBL] [Abstract][Full Text] [Related]
17. Potent Inhibition of Nicotinamide
Gao Y; van Haren MJ; Buijs N; Innocenti P; Zhang Y; Sartini D; Campagna R; Emanuelli M; Parsons RB; Jespers W; Gutiérrez-de-Terán H; van Westen GJP; Martin NI
J Med Chem; 2021 Sep; 64(17):12938-12963. PubMed ID: 34424711
[TBL] [Abstract][Full Text] [Related]
18. Human liver nicotinamide N-methyltransferase: ion-pairing radiochemical assay, biochemical properties and individual variation.
Rini J; Szumlanski C; Guerciolini R; Weinshilboum RM
Clin Chim Acta; 1990 Jan; 186(3):359-74. PubMed ID: 2311261
[TBL] [Abstract][Full Text] [Related]
19. Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains.
Scheller T; Orgacka H; Szumlanski CL; Weinshilboum RM
Pharmacogenetics; 1996 Feb; 6(1):43-53. PubMed ID: 8845860
[TBL] [Abstract][Full Text] [Related]
20. Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway.
Thomas MG; Sartini D; Emanuelli M; van Haren MJ; Martin NI; Mountford DM; Barlow DJ; Klamt F; Ramsden DB; Reza M; Parsons RB
Biochem J; 2016 Oct; 473(19):3253-67. PubMed ID: 27389312
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
