BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

210 related articles for article (PubMed ID: 34274950)

  • 1. Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia.
    Kopach O; Esteras N; Wray S; Abramov AY; Rusakov DA
    Cell Death Dis; 2021 Jul; 12(8):716. PubMed ID: 34274950
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia.
    Kopach O; Esteras N; Wray S; Rusakov DA; Abramov AY
    J Cell Sci; 2020 May; 133(10):. PubMed ID: 32299835
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Iovino M; Agathou S; González-Rueda A; Del Castillo Velasco-Herrera M; Borroni B; Alberici A; Lynch T; O'Dowd S; Geti I; Gaffney D; Vallier L; Paulsen O; Káradóttir RT; Spillantini MG
    Brain; 2015 Nov; 138(Pt 11):3345-59. PubMed ID: 26220942
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes.
    Verheyen A; Diels A; Reumers J; Van Hoorde K; Van den Wyngaert I; van Outryve d'Ydewalle C; De Bondt A; Kuijlaars J; De Muynck L; De Hoogt R; Bretteville A; Jaensch S; Buist A; Cabrera-Socorro A; Wray S; Ebneth A; Roevens P; Royaux I; Peeters PJ
    Stem Cell Reports; 2018 Aug; 11(2):363-379. PubMed ID: 30057263
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT.
    Sposito T; Preza E; Mahoney CJ; Setó-Salvia N; Ryan NS; Morris HR; Arber C; Devine MJ; Houlden H; Warner TT; Bushell TJ; Zagnoni M; Kunath T; Livesey FJ; Fox NC; Rossor MN; Hardy J; Wray S
    Hum Mol Genet; 2015 Sep; 24(18):5260-9. PubMed ID: 26136155
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration.
    Esteras N; Rohrer JD; Hardy J; Wray S; Abramov AY
    Redox Biol; 2017 Aug; 12():410-422. PubMed ID: 28319892
    [TBL] [Abstract][Full Text] [Related]  

  • 7. MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations.
    Biswas MHU; Almeida S; Lopez-Gonzalez R; Mao W; Zhang Z; Karydas A; Geschwind MD; Biernat J; Mandelkow EM; Futai K; Miller BL; Gao FB
    Stem Cell Reports; 2016 Sep; 7(3):316-324. PubMed ID: 27594586
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells.
    Wren MC; Zhao J; Liu CC; Murray ME; Atagi Y; Davis MD; Fu Y; Okano HJ; Ogaki K; Strongosky AJ; Tacik P; Rademakers R; Ross OA; Dickson DW; Wszolek ZK; Kanekiyo T; Bu G
    Mol Neurodegener; 2015 Sep; 10():46. PubMed ID: 26373282
    [TBL] [Abstract][Full Text] [Related]  

  • 9. [The genetics of dementias. Part 1: Molecular basis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)].
    Kowalska A
    Postepy Hig Med Dosw (Online); 2009 Jun; 63():278-86. PubMed ID: 19535823
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration.
    Giannini LAA; Ohm DT; Rozemuller AJM; Dratch L; Suh E; van Deerlin VM; Trojanowski JQ; Lee EB; van Swieten JC; Grossman M; Seelaar H; Irwin DJ;
    Acta Neuropathol; 2022 Dec; 144(6):1065-1084. PubMed ID: 36066634
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.
    García-León JA; Cabrera-Socorro A; Eggermont K; Swijsen A; Terryn J; Fazal R; Nami F; Ordovás L; Quiles A; Lluis F; Serneels L; Wierda K; Sierksma A; Kreir M; Pestana F; Van Damme P; De Strooper B; Thorrez L; Ebneth A; Verfaillie CM
    Alzheimers Dement; 2018 Oct; 14(10):1261-1280. PubMed ID: 30036493
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
    Karch CM; Kao AW; Karydas A; Onanuga K; Martinez R; Argouarch A; Wang C; Huang C; Sohn PD; Bowles KR; Spina S; Silva MC; Marsh JA; Hsu S; Pugh DA; Ghoshal N; Norton J; Huang Y; Lee SE; Seeley WW; Theofilas P; Grinberg LT; Moreno F; McIlroy K; Boeve BF; Cairns NJ; Crary JF; Haggarty SJ; Ichida JK; Kosik KS; Miller BL; Gan L; Goate AM; Temple S;
    Stem Cell Reports; 2019 Nov; 13(5):939-955. PubMed ID: 31631020
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Familial tauopathy with P364S MAPT mutation: clinical course, neuropathology and ultrastructure of neuronal tau inclusions.
    Štrafela P; Pleško J; Magdič J; Koritnik B; Zupan A; Glavač D; Bresjanac M; Popović M
    Neuropathol Appl Neurobiol; 2018 Oct; 44(6):550-562. PubMed ID: 29215752
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.
    Forrest SL; Kril JJ; Stevens CH; Kwok JB; Hallupp M; Kim WS; Huang Y; McGinley CV; Werka H; Kiernan MC; Götz J; Spillantini MG; Hodges JR; Ittner LM; Halliday GM
    Brain; 2018 Feb; 141(2):521-534. PubMed ID: 29253099
    [TBL] [Abstract][Full Text] [Related]  

  • 15. MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD.
    Korn L; Speicher AM; Schroeter CB; Gola L; Kaehne T; Engler A; Disse P; Fernández-Orth J; Csatári J; Naumann M; Seebohm G; Meuth SG; Schöler HR; Wiendl H; Kovac S; Pawlowski M
    Redox Biol; 2023 Feb; 59():102597. PubMed ID: 36599286
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation.
    Setó-Salvia N; Esteras N; de Silva R; de Pablo-Fernandez E; Arber C; Toomey CE; Polke JM; Morris HR; Rohrer JD; Abramov AY; Patani R; Wray S; Warner TT
    J Cell Mol Med; 2022 Feb; 26(4):1327-1331. PubMed ID: 34951131
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.
    Bowles KR; Pugh DA; Pedicone C; Oja L; Weitzman SA; Liu Y; Chen JL; Disney MD; Goate AM
    bioRxiv; 2023 Jun; ():. PubMed ID: 37333200
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Generation of 17q21.31 duplication iPSC-derived neurons as a model for primary tauopathies.
    Miguel L; Rovelet-Lecrux A; Chambon P; Joly-Helas G; Rousseau S; Wallon D; Epelbaum S; Frébourg T; Campion D; Nicolas G; Lecourtois M
    Stem Cell Res; 2022 May; 61():102762. PubMed ID: 35358831
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons.
    Imamura K; Sahara N; Kanaan NM; Tsukita K; Kondo T; Kutoku Y; Ohsawa Y; Sunada Y; Kawakami K; Hotta A; Yawata S; Watanabe D; Hasegawa M; Trojanowski JQ; Lee VM; Suhara T; Higuchi M; Inoue H
    Sci Rep; 2016 Oct; 6():34904. PubMed ID: 27721502
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT).
    Rasmussen MA; Hjermind LE; Hasholt LF; Waldemar G; Nielsen JE; Clausen C; Hyttel P; Holst B
    Stem Cell Res; 2016 Jan; 16(1):75-8. PubMed ID: 27345789
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.