180 related articles for article (PubMed ID: 34303869)
1. Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020.
Roshdy E; Mustafa M; Shaltout AE; Radwan MO; Ibrahim MAA; Soliman ME; Fujita M; Otsuka M; Ali TFS
Eur J Med Chem; 2021 Nov; 224():113709. PubMed ID: 34303869
[TBL] [Abstract][Full Text] [Related]
2. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
Yang LL; Wang HL; Zhong L; Yuan C; Liu SY; Yu ZJ; Liu S; Yan YH; Wu C; Wang Y; Wang Z; Yu Y; Chen Q; Li GB
Eur J Med Chem; 2018 Jul; 155():806-823. PubMed ID: 29957526
[TBL] [Abstract][Full Text] [Related]
3. Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities.
Spiegelman NA; Price IR; Jing H; Wang M; Yang M; Cao J; Hong JY; Zhang X; Aramsangtienchai P; Sadhukhan S; Lin H
ChemMedChem; 2018 Sep; 13(18):1890-1894. PubMed ID: 30058233
[TBL] [Abstract][Full Text] [Related]
4. Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
Radwan MO; Ciftci HI; Ali TFS; Koga R; Tateishi H; Nakata A; Ito A; Yoshida M; Fujita M; Otsuka M
Bioorg Med Chem Lett; 2020 Oct; 30(19):127458. PubMed ID: 32755678
[TBL] [Abstract][Full Text] [Related]
5. Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells.
Dukanya ; Shanmugam MK; Rangappa S; Metri PK; Mohan S; Basappa ; Rangappa KS
Bioorg Med Chem Lett; 2020 Aug; 30(16):127330. PubMed ID: 32631535
[TBL] [Abstract][Full Text] [Related]
6. Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD
Mellini P; Itoh Y; Elboray EE; Tsumoto H; Li Y; Suzuki M; Takahashi Y; Tojo T; Kurohara T; Miyake Y; Miura Y; Kitao Y; Kotoku M; Iida T; Suzuki T
J Med Chem; 2019 Jun; 62(12):5844-5862. PubMed ID: 31144814
[TBL] [Abstract][Full Text] [Related]
7. Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.
Seifert T; Malo M; Kokkola T; Engen K; Fridén-Saxin M; Wallén EA; Lahtela-Kakkonen M; Jarho EM; Luthman K
J Med Chem; 2014 Dec; 57(23):9870-88. PubMed ID: 25383691
[TBL] [Abstract][Full Text] [Related]
8. Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
Farooqi AS; Hong JY; Cao J; Lu X; Price IR; Zhao Q; Kosciuk T; Yang M; Bai JJ; Lin H
J Med Chem; 2019 Apr; 62(8):4131-4141. PubMed ID: 30986062
[TBL] [Abstract][Full Text] [Related]
9. Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors.
Eren G; Bruno A; Guntekin-Ergun S; Cetin-Atalay R; Ozgencil F; Ozkan Y; Gozelle M; Kaya SG; Costantino G
J Mol Graph Model; 2019 Jun; 89():60-73. PubMed ID: 30870650
[TBL] [Abstract][Full Text] [Related]
10. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors.
Khalil NA; Ahmed EM; Zaher AF; El-Zoghbi MS; Sobh EA
Eur J Med Chem; 2020 Feb; 187():111926. PubMed ID: 31812033
[TBL] [Abstract][Full Text] [Related]
11. Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
Yang L; Ma X; Yuan C; He Y; Li L; Fang S; Xia W; He T; Qian S; Xu Z; Li G; Wang Z
Eur J Med Chem; 2017 Jul; 134():230-241. PubMed ID: 28415012
[TBL] [Abstract][Full Text] [Related]
12. Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies.
Chowdhury S; Sripathy S; Webster A; Park A; Lao U; Hsu JH; Loe T; Bedalov A; Simon JA
Molecules; 2020 Jan; 25(3):. PubMed ID: 31973227
[TBL] [Abstract][Full Text] [Related]
13. Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Moniot S; Forgione M; Lucidi A; Hailu GS; Nebbioso A; Carafa V; Baratta F; Altucci L; Giacché N; Passeri D; Pellicciari R; Mai A; Steegborn C; Rotili D
J Med Chem; 2017 Mar; 60(6):2344-2360. PubMed ID: 28240897
[TBL] [Abstract][Full Text] [Related]
14. Unexpected small molecules as novel SIRT2 suicide inhibitors.
Chen X; Zou Y; Wang J; Cao Z; Liu J; Li Y; Zhao Y; He B
Bioorg Med Chem; 2020 Mar; 28(6):115353. PubMed ID: 32061485
[TBL] [Abstract][Full Text] [Related]
15. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Rumpf T; Schiedel M; Karaman B; Roessler C; North BJ; Lehotzky A; Oláh J; Ladwein KI; Schmidtkunz K; Gajer M; Pannek M; Steegborn C; Sinclair DA; Gerhardt S; Ovádi J; Schutkowski M; Sippl W; Einsle O; Jung M
Nat Commun; 2015 Feb; 6():6263. PubMed ID: 25672491
[TBL] [Abstract][Full Text] [Related]
16. The role of SIRT2 in cancer: A novel therapeutic target.
Chen G; Huang P; Hu C
Int J Cancer; 2020 Dec; 147(12):3297-3304. PubMed ID: 32449165
[TBL] [Abstract][Full Text] [Related]
17. Assessment of SIRT2 Inhibitors in Mouse Models of Cancer.
Negrón Abril YL; Fernández I; Weiss RS
Methods Mol Biol; 2019; 1983():151-171. PubMed ID: 31087297
[TBL] [Abstract][Full Text] [Related]
18. Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells.
Hamaidi I; Zhang L; Kim N; Wang MH; Iclozan C; Fang B; Liu M; Koomen JM; Berglund AE; Yoder SJ; Yao J; Engelman RW; Creelan BC; Conejo-Garcia JR; Antonia SJ; Mulé JJ; Kim S
Cell Metab; 2020 Sep; 32(3):420-436.e12. PubMed ID: 32768387
[TBL] [Abstract][Full Text] [Related]
19. Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
Cui H; Kamal Z; Ai T; Xu Y; More SS; Wilson DJ; Chen L
J Med Chem; 2014 Oct; 57(20):8340-57. PubMed ID: 25275824
[TBL] [Abstract][Full Text] [Related]
20. Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers.
Wang T; Xu Z; Lu Y; Shi J; Liu W; Zhang C; Jiang Z; Qi B; Bai L
Curr Top Med Chem; 2019; 19(12):1051-1058. PubMed ID: 31074370
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]