BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

138 related articles for article (PubMed ID: 34303878)

  • 1. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
    Byles V; Cormerais Y; Kalafut K; Barrera V; Hughes Hallett JE; Sui SH; Asara JM; Adams CM; Hoxhaj G; Ben-Sahra I; Manning BD
    Mol Metab; 2021 Nov; 53():101309. PubMed ID: 34303878
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
    Torrence ME; MacArthur MR; Hosios AM; Valvezan AJ; Asara JM; Mitchell JR; Manning BD
    Elife; 2021 Mar; 10():. PubMed ID: 33646118
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes.
    Griffiths A; Wang J; Song Q; Iyamu ID; Liu L; Park J; Jiang Y; Huang R; Song Z
    Am J Physiol Cell Physiol; 2021 Sep; 321(3):C585-C595. PubMed ID: 34378991
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.
    Al-Baghdadi RJT; Nikonorova IA; Mirek ET; Wang Y; Park J; Belden WJ; Wek RC; Anthony TG
    Sci Rep; 2017 Apr; 7(1):1272. PubMed ID: 28455513
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Activation of mTORC1 by Free Fatty Acids Suppresses LAMP2 and Autophagy Function via ER Stress in Alcohol-Related Liver Disease.
    Guo W; Zhong W; Hao L; Sun X; Zhou Z
    Cells; 2021 Oct; 10(10):. PubMed ID: 34685712
    [TBL] [Abstract][Full Text] [Related]  

  • 6. TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
    O'Leary EM; Tian Y; Nigdelioglu R; Witt LJ; Cetin-Atalay R; Meliton AY; Woods PS; Kimmig LM; Sun KA; Gökalp GA; Mutlu GM; Hamanaka RB
    Am J Respir Cell Mol Biol; 2020 Nov; 63(5):601-612. PubMed ID: 32668192
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
    Kim HJ; Joe Y; Kim SK; Park SU; Park J; Chen Y; Kim J; Ryu J; Cho GJ; Surh YJ; Ryter SW; Kim UH; Chung HT
    Free Radic Biol Med; 2017 Sep; 110():81-91. PubMed ID: 28578014
    [TBL] [Abstract][Full Text] [Related]  

  • 8. ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation.
    Xu D; Dai W; Kutzler L; Lacko HA; Jefferson LS; Dennis MD; Kimball SR
    J Nutr; 2020 May; 150(5):1022-1030. PubMed ID: 31875479
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
    Nikonorova IA; Al-Baghdadi RJT; Mirek ET; Wang Y; Goudie MP; Wetstein BB; Dixon JL; Hine C; Mitchell JR; Adams CM; Wek RC; Anthony TG
    J Biol Chem; 2017 Apr; 292(16):6786-6798. PubMed ID: 28242759
    [TBL] [Abstract][Full Text] [Related]  

  • 10. mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4.
    Park Y; Reyna-Neyra A; Philippe L; Thoreen CC
    Cell Rep; 2017 May; 19(6):1083-1090. PubMed ID: 28494858
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
    Nikonorova IA; Mirek ET; Signore CC; Goudie MP; Wek RC; Anthony TG
    J Biol Chem; 2018 Apr; 293(14):5005-5015. PubMed ID: 29449374
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Resistance exercise enhances long-term mTORC1 sensitivity to leucine.
    D'Hulst G; Masschelein E; De Bock K
    Mol Metab; 2022 Dec; 66():101615. PubMed ID: 36252815
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ATF4 Regulates CD4
    Yang X; Xia R; Yue C; Zhai W; Du W; Yang Q; Cao H; Chen X; Obando D; Zhu Y; Chen X; Chen JJ; Piganelli J; Wipf P; Jiang Y; Xiao G; Wu C; Jiang J; Lu B
    Cell Rep; 2018 May; 23(6):1754-1766. PubMed ID: 29742431
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).
    Dennis MD; McGhee NK; Jefferson LS; Kimball SR
    Cell Signal; 2013 Dec; 25(12):2709-16. PubMed ID: 24018049
    [TBL] [Abstract][Full Text] [Related]  

  • 15. mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b.
    Uehara K; Lee WD; Stefkovich M; Biswas D; Santoleri D; Garcia Whitlock A; Quinn W; Coopersmith T; Creasy KT; Rader DJ; Sakamoto K; Rabinowitz JD; Titchenell PM
    J Clin Invest; 2024 Jan; 134(7):. PubMed ID: 38290087
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4.
    Alonge KM; Meares GP; Hillgartner FB
    J Biol Chem; 2017 Mar; 292(13):5239-5252. PubMed ID: 28188284
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.
    Guan BJ; Krokowski D; Majumder M; Schmotzer CL; Kimball SR; Merrick WC; Koromilas AE; Hatzoglou M
    J Biol Chem; 2014 May; 289(18):12593-611. PubMed ID: 24648524
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR).
    van der Mijn JC; Chen Q; Laursen KB; Khani F; Wang X; Dorsaint P; Sboner A; Gross SS; Nanus DM; Gudas LJ
    Mol Carcinog; 2022 Sep; 61(9):851-864. PubMed ID: 35726553
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice.
    Gong Q; Hu Z; Zhang F; Cui A; Chen X; Jiang H; Gao J; Chen X; Han Y; Liang Q; Ye D; Shi L; Chin YE; Wang Y; Xiao H; Guo F; Liu Y; Zang M; Xu A; Li Y
    Hepatology; 2016 Aug; 64(2):425-38. PubMed ID: 26926384
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
    Copps KD; Hançer NJ; Qiu W; White MF
    J Biol Chem; 2016 Apr; 291(16):8602-17. PubMed ID: 26846849
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.