168 related articles for article (PubMed ID: 34329992)
21. Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study.
Alzahrani AY; Ammar YA; Abu-Elghait M; Salem MA; Assiri MA; Ali TE; Ragab A
Bioorg Chem; 2022 Feb; 119():105571. PubMed ID: 34959177
[TBL] [Abstract][Full Text] [Related]
22. Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge.
Li H; Fang F; Liu Y; Xue L; Wang M; Guo Y; Wang X; Tian C; Liu J; Zhang Z
Bioorg Med Chem; 2018 May; 26(9):2674-2685. PubMed ID: 29691154
[TBL] [Abstract][Full Text] [Related]
23. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
Gangjee A; Vasudevan A; Queener SF; Kisliuk RL
J Med Chem; 1996 Mar; 39(7):1438-46. PubMed ID: 8691474
[TBL] [Abstract][Full Text] [Related]
24. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Gangjee A; Lin X; Kisliuk RL; McGuire JJ
J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
[TBL] [Abstract][Full Text] [Related]
25. Nonclassical antifolates, part 3: synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones.
Al-Omary FA; Hassan GS; El-Messery SM; Nagi MN; Habib el-SE; El-Subbagh HI
Eur J Med Chem; 2013 May; 63():33-45. PubMed ID: 23454532
[TBL] [Abstract][Full Text] [Related]
26. Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors.
Zhou X; Lin K; Ma X; Chui WK; Zhou W
Eur J Med Chem; 2017 Jan; 125():1279-1288. PubMed ID: 27886545
[TBL] [Abstract][Full Text] [Related]
27. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents.
Tian C; Wang M; Han Z; Fang F; Zhang Z; Wang X; Liu J
Eur J Med Chem; 2017 Sep; 138():630-643. PubMed ID: 28711701
[TBL] [Abstract][Full Text] [Related]
28. Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
Rosowsky A; Papoulis AT; Forsch RA; Queener SF
J Med Chem; 1999 Mar; 42(6):1007-17. PubMed ID: 10090784
[TBL] [Abstract][Full Text] [Related]
29. Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation.
Carrasco MP; Enyedy EA; Krupenko NI; Krupenko SA; Nuti E; Tuccinardi T; Santamaria S; Rossello A; Martinelli A; Santos MA
Med Chem; 2011 Jul; 7(4):265-74. PubMed ID: 21568878
[TBL] [Abstract][Full Text] [Related]
30. Synthesis, dihydrofolate reductase inhibition, anti-proliferative testing, and saturation transfer difference ¹H-NMR study of some new 2-substituted-4,6-diaminopyrimidine derivatives.
Mohebbi S; Falcón-Pérez JM; González E; Millet O; Mato JM; Kobarfard F
Chem Pharm Bull (Tokyo); 2012; 60(1):70-8. PubMed ID: 22223377
[TBL] [Abstract][Full Text] [Related]
31. DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents.
Raimondi MV; Randazzo O; La Franca M; Barone G; Vignoni E; Rossi D; Collina S
Molecules; 2019 Mar; 24(6):. PubMed ID: 30909399
[TBL] [Abstract][Full Text] [Related]
32. Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones.
Al-Omary FA; Abou-Zeid LA; Nagi MN; Habib el-SE; Abdel-Aziz AA; El-Azab AS; Abdel-Hamide SG; Al-Omar MA; Al-Obaid AM; El-Subbagh HI
Bioorg Med Chem; 2010 Apr; 18(8):2849-63. PubMed ID: 20350811
[TBL] [Abstract][Full Text] [Related]
33. Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity.
Gangjee A; Zeng Y; Ihnat M; Warnke LA; Green DW; Kisliuk RL; Lin FT
Bioorg Med Chem; 2005 Sep; 13(18):5475-91. PubMed ID: 16039863
[TBL] [Abstract][Full Text] [Related]
34. Synthesis, antitumor testing and molecular modeling study of some new 6-substituted amido, azo or thioureido-quinazolin-4(3H)-ones.
Sabry MA; Ewida HA; Hassan GS; Ghaly MA; El-Subbagh HI
Bioorg Chem; 2019 Jul; 88():102923. PubMed ID: 30991189
[TBL] [Abstract][Full Text] [Related]
35. Synthesis and biological evaluation of novel antifolate analogs as potential anticancer treatment.
Stoicescu DF; Rotaru M
Anticancer Agents Med Chem; 2013 Feb; 13(2):364-72. PubMed ID: 23157590
[TBL] [Abstract][Full Text] [Related]
36. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
Rosowsky A; Wright JE; Vaidya CM; Bader H; Forsch RA; Mota CE; Pardo J; Chen CS; Chen YN
J Med Chem; 1998 Dec; 41(26):5310-9. PubMed ID: 9857098
[TBL] [Abstract][Full Text] [Related]
37. Rational modification of the lead molecule: Enhancement in the anticancer and dihydrofolate reductase inhibitory activity.
Kaur J; Kaur S; Singh P
Bioorg Med Chem Lett; 2016 Apr; 26(8):1936-40. PubMed ID: 26979156
[TBL] [Abstract][Full Text] [Related]
38. The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Gangjee A; Jain HD; Queener SF; Kisliuk RL
J Med Chem; 2008 Aug; 51(15):4589-600. PubMed ID: 18605720
[TBL] [Abstract][Full Text] [Related]
39. Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Gangjee A; Vidwans A; Elzein E; McGuire JJ; Queener SF; Kisliuk RL
J Med Chem; 2001 Jun; 44(12):1993-2003. PubMed ID: 11384244
[TBL] [Abstract][Full Text] [Related]
40. Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-
Salem IM; Mostafa SM; Salama I; El-Sabbagh OI; Hegazy WAH; Ibrahim TS
J Enzyme Inhib Med Chem; 2023 Dec; 38(1):203-215. PubMed ID: 36382444
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
