These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

201 related articles for article (PubMed ID: 34360555)

  • 1. Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies.
    Pang L; Weeks SD; Juhás M; Strelkov SV; Zitko J; Van Aerschot A
    Int J Mol Sci; 2021 Jul; 22(15):. PubMed ID: 34360555
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.
    Adachi R; Okada K; Skene R; Ogawa K; Miwa M; Tsuchinaga K; Ohkubo S; Henta T; Kawamoto T
    Biochem Biophys Res Commun; 2017 Jun; 488(2):393-399. PubMed ID: 28501621
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of Selective Novel Hits against
    Nyamai DW; Tastan Bishop Ö
    Int J Mol Sci; 2020 May; 21(11):. PubMed ID: 32471245
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
    Son J; Lee EH; Park M; Kim JH; Kim J; Kim S; Jeon YH; Hwang KY
    Acta Crystallogr D Biol Crystallogr; 2013 Oct; 69(Pt 10):2136-45. PubMed ID: 24100331
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase.
    Yaremchuk A; Tukalo M; Grøtli M; Cusack S
    J Mol Biol; 2001 Jun; 309(4):989-1002. PubMed ID: 11399074
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In silico discovery of aminoacyl-tRNA synthetase inhibitors.
    Zhao Y; Meng Q; Bai L; Zhou H
    Int J Mol Sci; 2014 Jan; 15(1):1358-73. PubMed ID: 24447926
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
    Hewitt SN; Dranow DM; Horst BG; Abendroth JA; Forte B; Hallyburton I; Jansen C; Baragaña B; Choi R; Rivas KL; Hulverson MA; Dumais M; Edwards TE; Lorimer DD; Fairlamb AH; Gray DW; Read KD; Lehane AM; Kirk K; Myler PJ; Wernimont A; Walpole C; Stacy R; Barrett LK; Gilbert IH; Van Voorhis WC
    ACS Infect Dis; 2017 Jan; 3(1):34-44. PubMed ID: 27798837
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
    Nautiyal M; De Graef S; Pang L; Gadakh B; Strelkov SV; Weeks SD; Van Aerschot A
    Eur J Med Chem; 2019 Jul; 173():154-166. PubMed ID: 30995568
    [TBL] [Abstract][Full Text] [Related]  

  • 9. tRNA(Pro) anticodon recognition by Thermus thermophilus prolyl-tRNA synthetase.
    Cusack S; Yaremchuk A; Krikliviy I; Tukalo M
    Structure; 1998 Jan; 6(1):101-8. PubMed ID: 9493271
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
    Jain V; Kikuchi H; Oshima Y; Sharma A; Yogavel M
    J Struct Funct Genomics; 2014 Dec; 15(4):181-90. PubMed ID: 25047712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
    Zhou H; Sun L; Yang XL; Schimmel P
    Nature; 2013 Feb; 494(7435):121-4. PubMed ID: 23263184
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening.
    Shapiro AB; Plant H; Walsh J; Sylvester M; Hu J; Gao N; Livchak S; Tentarelli S; Thresher J
    J Biomol Screen; 2014 Sep; 19(8):1137-46. PubMed ID: 24820111
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibitors of aminoacyl-tRNA synthetases as antimycobacterial compounds: An up-to-date review.
    Bouz G; Zitko J
    Bioorg Chem; 2021 May; 110():104806. PubMed ID: 33799176
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.
    De Ruysscher D; Pang L; De Graef S; Nautiyal M; De Borggraeve WM; Rozenski J; Strelkov SV; Weeks SD; Van Aerschot A
    Eur J Med Chem; 2019 Jul; 174():252-264. PubMed ID: 31048140
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Aminoacyl-tRNA synthetase inhibitors as potent antibacterials.
    Lv PC; Zhu HL
    Curr Med Chem; 2012; 19(21):3550-63. PubMed ID: 22680640
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
    Fang P; Han H; Wang J; Chen K; Chen X; Guo M
    Chem Biol; 2015 Jun; 22(6):734-44. PubMed ID: 26074468
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery.
    Pang L; Weeks SD; Van Aerschot A
    Int J Mol Sci; 2021 Feb; 22(4):. PubMed ID: 33578647
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.
    Zhang B; Pang L; Nautiyal M; De Graef S; Gadakh B; Lescrinier E; Rozenski J; Strelkov SV; Weeks SD; Van Aerschot A
    Molecules; 2020 Oct; 25(20):. PubMed ID: 33081246
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase.
    Gadakh B; Vondenhoff G; Pang L; Nautiyal M; De Graef S; Strelkov SV; Weeks SD; Van Aerschot A
    Bioorg Med Chem; 2020 Sep; 28(17):115645. PubMed ID: 32773091
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Active site nanospace of aminoacyl tRNA synthetase: difference between the class I and class II synthetases.
    Dutta S; Choudhury K; Banik SD; Nandi N
    J Nanosci Nanotechnol; 2014 Mar; 14(3):2280-98. PubMed ID: 24745224
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.