BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 34377364)

  • 1. Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations.
    An X; Bai Q; Bing Z; Liu H; Yao X
    Comput Struct Biotechnol J; 2021; 19():3978-3989. PubMed ID: 34377364
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
    Lu J; Byrne N; Wang J; Bricogne G; Brown FK; Chobanian HR; Colletti SL; Di Salvo J; Thomas-Fowlkes B; Guo Y; Hall DL; Hadix J; Hastings NB; Hermes JD; Ho T; Howard AD; Josien H; Kornienko M; Lumb KJ; Miller MW; Patel SB; Pio B; Plummer CW; Sherborne BS; Sheth P; Souza S; Tummala S; Vonrhein C; Webb M; Allen SJ; Johnston JM; Weinglass AB; Sharma S; Soisson SM
    Nat Struct Mol Biol; 2017 Jul; 24(7):570-577. PubMed ID: 28581512
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
    Srivastava A; Yano J; Hirozane Y; Kefala G; Gruswitz F; Snell G; Lane W; Ivetac A; Aertgeerts K; Nguyen J; Jennings A; Okada K
    Nature; 2014 Sep; 513(7516):124-7. PubMed ID: 25043059
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Revealing the Positive Binding Cooperativity Mechanism between the Orthosteric and the Allosteric Antagonists of CCR2 by Metadynamics and Gaussian Accelerated Molecular Dynamics Simulations.
    An X; Bai Q; Bing Z; Liu H; Zhang Q; Liu H; Yao X
    ACS Chem Neurosci; 2020 Feb; 11(4):628-637. PubMed ID: 31968162
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics.
    Atanasio S; Deganutti G; Reynolds CA
    J Comput Aided Mol Des; 2020 Nov; 34(11):1181-1193. PubMed ID: 32851580
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Computational Insights into Molecular Activation and Positive Cooperative Mechanisms of FFAR1 Modulators.
    Teng D; Chen J; Li D; Wu Z; Li W; Tang Y; Liu G
    J Chem Inf Model; 2020 Jun; 60(6):3214-3230. PubMed ID: 32338509
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Graded activation and free energy landscapes of a muscarinic G-protein-coupled receptor.
    Miao Y; McCammon JA
    Proc Natl Acad Sci U S A; 2016 Oct; 113(43):12162-12167. PubMed ID: 27791003
    [TBL] [Abstract][Full Text] [Related]  

  • 8. How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the κ-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation.
    An X; Bai Q; Bing Z; Zhou S; Shi D; Liu H; Yao X
    ACS Chem Neurosci; 2019 Mar; 10(3):1575-1584. PubMed ID: 30372027
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Investigating the Dynamic Binding Behavior of PMX53 Cooperating with Allosteric Antagonist NDT9513727 to C5a Anaphylatoxin Chemotactic Receptor 1 through Gaussian Accelerated Molecular Dynamics and Free-Energy Perturbation Simulations.
    Xiaoli A; Yuzhen N; Qiong Y; Yang L; Yao X; Bing Z
    ACS Chem Neurosci; 2022 Dec; 13(23):3502-3511. PubMed ID: 36428153
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Investigation of the Binding Interaction of Fatty Acids with Human G Protein-Coupled Receptor 40 Using a Site-Specific Fluorescence Probe by Flow Cytometry.
    Ren XM; Cao LY; Zhang J; Qin WP; Yang Y; Wan B; Guo LH
    Biochemistry; 2016 Apr; 55(13):1989-96. PubMed ID: 26974599
    [TBL] [Abstract][Full Text] [Related]  

  • 11. GPR40-Mediated G
    Rives ML; Rady B; Swanson N; Zhao S; Qi J; Arnoult E; Bakaj I; Mancini A; Breton B; Lee SP; Player MR; Pocai A
    Mol Pharmacol; 2018 Jun; 93(6):581-591. PubMed ID: 29572336
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1.
    Lückmann M; Trauelsen M; Bentsen MA; Nissen TAD; Martins J; Fallah Z; Nygaard MM; Papaleo E; Lindorff-Larsen K; Schwartz TW; Frimurer TM
    Proc Natl Acad Sci U S A; 2019 Apr; 116(14):7123-7128. PubMed ID: 30872479
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural basis for GPR40 allosteric agonism and incretin stimulation.
    Ho JD; Chau B; Rodgers L; Lu F; Wilbur KL; Otto KA; Chen Y; Song M; Riley JP; Yang HC; Reynolds NA; Kahl SD; Lewis AP; Groshong C; Madsen RE; Conners K; Lineswala JP; Gheyi T; Saflor MD; Lee MR; Benach J; Baker KA; Montrose-Rafizadeh C; Genin MJ; Miller AR; Hamdouchi C
    Nat Commun; 2018 Apr; 9(1):1645. PubMed ID: 29695780
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus.
    Rani L; Grewal AS; Sharma N; Singh S
    Mini Rev Med Chem; 2021; 21(4):426-470. PubMed ID: 33100202
    [TBL] [Abstract][Full Text] [Related]  

  • 15. GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.
    Hauge M; Vestmar MA; Husted AS; Ekberg JP; Wright MJ; Di Salvo J; Weinglass AB; Engelstoft MS; Madsen AN; Lückmann M; Miller MW; Trujillo ME; Frimurer TM; Holst B; Howard AD; Schwartz TW
    Mol Metab; 2015 Jan; 4(1):3-14. PubMed ID: 25685685
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The mechanism of high affinity pentasaccharide binding to antithrombin, insights from Gaussian accelerated molecular dynamics simulations.
    Balogh G; Komáromi I; Bereczky Z
    J Biomol Struct Dyn; 2020 Oct; 38(16):4718-4732. PubMed ID: 31686597
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dynamic Insights into the Self-Activation Pathway and Allosteric Regulation of the Orphan G-Protein-Coupled Receptor GPR52.
    Wu Z; Han Z; Tao L; Sun X; Su J; Hu J; Li C
    J Chem Inf Model; 2023 Sep; 63(18):5847-5862. PubMed ID: 37651308
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Gaussian Accelerated Molecular Dynamics in NAMD.
    Pang YT; Miao Y; Wang Y; McCammon JA
    J Chem Theory Comput; 2017 Jan; 13(1):9-19. PubMed ID: 28034310
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The role of conformational ensembles in ligand recognition in G-protein coupled receptors.
    Niesen MJ; Bhattacharya S; Vaidehi N
    J Am Chem Soc; 2011 Aug; 133(33):13197-204. PubMed ID: 21766860
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.
    Nguyen AT; Vecchio EA; Thomas T; Nguyen TD; Aurelio L; Scammells PJ; White PJ; Sexton PM; Gregory KJ; May LT; Christopoulos A
    Mol Pharmacol; 2016 Dec; 90(6):715-725. PubMed ID: 27683013
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.