These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

452 related articles for article (PubMed ID: 34425095)

  • 1. Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
    Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Rydén M; Näslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
    Gastroenterology; 2021 Dec; 161(6):1982-1997.e11. PubMed ID: 34425095
    [TBL] [Abstract][Full Text] [Related]  

  • 2. IRG1/itaconate alleviates acute liver injury in septic mice by suppressing NLRP3 expression and its mediated macrophage pyroptosis via regulation of the Nrf2 pathway.
    Zhou P; Yang L; Li R; Yin Y; Xie G; Liu X; Shi L; Tao K; Zhang P
    Int Immunopharmacol; 2024 Jun; 135():112277. PubMed ID: 38788445
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Immune-Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2-Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia-Reperfusion Injury.
    Yi Z; Deng M; Scott MJ; Fu G; Loughran PA; Lei Z; Li S; Sun P; Yang C; Li W; Xu H; Huang F; Billiar TR
    Hepatology; 2020 Oct; 72(4):1394-1411. PubMed ID: 31997373
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Acod1/itaconate activates Nrf2 in pulmonary microvascular endothelial cells to protect against the obesity-induced pulmonary microvascular endotheliopathy.
    Zhu L; Wu Z; Liu Y; Ming Y; Xie P; Jiang M; Qi Y
    Respir Res; 2024 May; 25(1):205. PubMed ID: 38730297
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury.
    Zheng Y; Chen Z; She C; Lin Y; Hong Y; Shi L; Zhang Y; Cao P; Xu X
    Cell Death Dis; 2020 Sep; 11(9):772. PubMed ID: 32943614
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Immune-responsive gene 1 protects against liver injury caused by concanavalin A via the activation Nrf2/HO-1 pathway and inhibition of ROS activation pathways.
    Yang W; Wang Y; Zhang P; Sun X; Chen X; Yu J; Shi L; Yin Y; Tao K; Li R
    Free Radic Biol Med; 2022 Mar; 182():108-118. PubMed ID: 35231555
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis.
    Luo Z; Sheng Z; Hu L; Shi L; Tian Y; Zhao X; Yang W; Xiao Z; Shen D; Wu W; Lan T; Zhao B; Wang X; Zhuang N; Zhang JN; Wang Y; Lu Y; Wang L; Zhang C; Wang P; An J; Yang F; Li Q
    EBioMedicine; 2024 Mar; 101():104993. PubMed ID: 38324982
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Immune response gene 1 deficiency aggravates high fat diet-induced nonalcoholic fatty liver disease via promotion of redox-sensitive AKT suppression.
    Zhang X; Zhi Y; Zan X; Fan K; Chen K; Zhao S; Dai X; Li L; Yang Y; Hu K; Gong X; Zhang L
    Biochim Biophys Acta Mol Basis Dis; 2023 Apr; 1869(4):166656. PubMed ID: 36706797
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage.
    Németh B; Doczi J; Csete D; Kacso G; Ravasz D; Adams D; Kiss G; Nagy AM; Horvath G; Tretter L; Mócsai A; Csépányi-Kömi R; Iordanov I; Adam-Vizi V; Chinopoulos C
    FASEB J; 2016 Jan; 30(1):286-300. PubMed ID: 26358042
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
    Adam J; Hatipoglu E; O'Flaherty L; Ternette N; Sahgal N; Lockstone H; Baban D; Nye E; Stamp GW; Wolhuter K; Stevens M; Fischer R; Carmeliet P; Maxwell PH; Pugh CW; Frizzell N; Soga T; Kessler BM; El-Bahrawy M; Ratcliffe PJ; Pollard PJ
    Cancer Cell; 2011 Oct; 20(4):524-37. PubMed ID: 22014577
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice.
    Fan K; Zan X; Zhi Y; Yang Y; Hu K; Zhang X; Zhang X; Zhao S; Chen K; Gong X; Tian R; Zhang L
    Biochem Biophys Res Commun; 2022 Jun; 607():103-109. PubMed ID: 35367821
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.
    Song H; Xu T; Feng X; Lai Y; Yang Y; Zheng H; He X; Wei G; Liao W; Liao Y; Zhong L; Bin J
    EBioMedicine; 2020 Jul; 57():102832. PubMed ID: 32574955
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
    Qian Z; Xia M; Zhao T; Li Y; Li G; Zhang Y; Li H; Yang L
    Clin Transl Med; 2024 Apr; 14(4):e1661. PubMed ID: 38644791
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response.
    Sun KA; Li Y; Meliton AY; Woods PS; Kimmig LM; Cetin-Atalay R; Hamanaka RB; Mutlu GM
    Elife; 2020 Apr; 9():. PubMed ID: 32255424
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibiting miR-27a and miR-142-5p attenuate nonalcoholic fatty liver disease by regulating Nrf2 signaling pathway.
    Teimouri M; Hosseini H; Shabani M; Koushki M; Noorbakhsh F; Meshkani R
    IUBMB Life; 2020 Mar; 72(3):361-372. PubMed ID: 31889412
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
    Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C; Li X; Shen JX; Akbar N; Haag L; Ellis E; Wålhen K; Näslund E; Thorell A; Choudhury RP; Lauschke VM; Rydén M; Craige SM; Aouadi M
    Sci Transl Med; 2020 Feb; 12(532):. PubMed ID: 32102936
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
    Mills EL; Ryan DG; Prag HA; Dikovskaya D; Menon D; Zaslona Z; Jedrychowski MP; Costa ASH; Higgins M; Hams E; Szpyt J; Runtsch MC; King MS; McGouran JF; Fischer R; Kessler BM; McGettrick AF; Hughes MM; Carroll RG; Booty LM; Knatko EV; Meakin PJ; Ashford MLJ; Modis LK; Brunori G; Sévin DC; Fallon PG; Caldwell ST; Kunji ERS; Chouchani ET; Frezza C; Dinkova-Kostova AT; Hartley RC; Murphy MP; O'Neill LA
    Nature; 2018 Apr; 556(7699):113-117. PubMed ID: 29590092
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury.
    Yang L; Zhou P; Li R; Yin Y; Xie G; Shi L; Zhang P; Tao K
    Mol Biol Rep; 2024 Apr; 51(1):533. PubMed ID: 38642169
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance.
    Yang H; Wu JW; Wang SP; Severi I; Sartini L; Frizzell N; Cinti S; Yang G; Mitchell GA
    Diabetes; 2016 Nov; 65(11):3396-3409. PubMed ID: 27554470
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A MicroRNA93-Interferon Regulatory Factor-9-Immunoresponsive Gene-1-Itaconic Acid Pathway Modulates M2-Like Macrophage Polarization to Revascularize Ischemic Muscle.
    Ganta VC; Choi MH; Kutateladze A; Fox TE; Farber CR; Annex BH
    Circulation; 2017 Jun; 135(24):2403-2425. PubMed ID: 28356443
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.