BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 34426152)

  • 1. Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries.
    Tao Y; Hao X; Jing L; Sun L; Cherukupalli S; Liu S; Wu G; Xu S; Zhang X; Shi X; Song Y; Liu X; Zhan P
    Bioorg Chem; 2021 Oct; 115():105254. PubMed ID: 34426152
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.
    Jing L; Wu G; Hao X; Olotu FA; Kang D; Chen CH; Lee KH; Soliman MES; Liu X; Song Y; Zhan P
    Eur J Med Chem; 2019 Dec; 183():111696. PubMed ID: 31541869
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based development of novel triazoles and related thiazolotriazoles as anticancer agents and Cdc25A/B phosphatase inhibitors. Synthesis, in vitro biological evaluation, molecular docking and in silico ADME-T studies.
    Rostom SAF; Badr MH; Abd El Razik HA; Ashour HMA
    Eur J Med Chem; 2017 Oct; 139():263-279. PubMed ID: 28803043
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.
    Lazo JS; Aslan DC; Southwick EC; Cooley KA; Ducruet AP; Joo B; Vogt A; Wipf P
    J Med Chem; 2001 Nov; 44(24):4042-9. PubMed ID: 11708908
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells.
    Capasso A; Cerchia C; Di Giovanni C; Granato G; Albano F; Romano S; De Vendittis E; Ruocco MR; Lavecchia A
    Oncotarget; 2015 Nov; 6(37):40202-22. PubMed ID: 26474275
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25.
    Schepetkin IA; Karpenko AS; Khlebnikov AI; Shibinska MO; Levandovskiy IA; Kirpotina LN; Danilenko NV; Quinn MT
    Eur J Med Chem; 2019 Dec; 183():111719. PubMed ID: 31563013
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.
    Sarkis M; Tran DN; Kolb S; Miteva MA; Villoutreix BO; Garbay C; Braud E
    Bioorg Med Chem Lett; 2012 Dec; 22(24):7345-50. PubMed ID: 23141909
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effective Pharmacophore for CDC25 Phosphatases Enzyme Inhibitors: Newly Synthesized Bromothiazolopyrimidine Derivatives.
    El-Shahat M; Salama MAM; El-Farargy AF; Ali MM; Ahmed DM
    Mini Rev Med Chem; 2021; 21(1):118-131. PubMed ID: 32560601
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells.
    Alam MM; Malebari AM; Syed N; Neamatallah T; Almalki ASA; Elhenawy AA; Obaid RJ; Alsharif MA
    Bioorg Med Chem; 2021 May; 38():116136. PubMed ID: 33894490
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity.
    Brun MP; Braud E; Angotti D; Mondésert O; Quaranta M; Montes M; Miteva M; Gresh N; Ducommun B; Garbay C
    Bioorg Med Chem; 2005 Aug; 13(16):4871-9. PubMed ID: 15921913
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells.
    Aliotta F; Nasso R; Rullo R; Arcucci A; Avagliano A; Simonetti M; Sanità G; Masullo M; Lavecchia A; Ruocco MR; Vendittis E
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):1866-1878. PubMed ID: 32990107
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library.
    Johnston PA; Foster CA; Tierno MB; Shun TY; Shinde SN; Paquette WD; Brummond KM; Wipf P; Lazo JS
    Assay Drug Dev Technol; 2009 Jun; 7(3):250-65. PubMed ID: 19530895
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light.
    Alchab F; Sibille E; Ettouati L; Bana E; Bouaziz Z; Mularoni A; Monniot E; Bagrel D; Jose J; Le Borgne M; Chaimbault P
    J Enzyme Inhib Med Chem; 2016; 31(sup3):25-32. PubMed ID: 27362889
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.
    Chen HJ; Liu Y; Wang LN; Shen Q; Li J; Nan FJ
    Bioorg Med Chem Lett; 2010 May; 20(9):2876-9. PubMed ID: 20363629
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate.
    Song Y; Lin X; Kang D; Li X; Zhan P; Liu X; Zhang Q
    Eur J Med Chem; 2014 Jul; 82():293-307. PubMed ID: 24922544
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.
    Lavecchia A; Di Giovanni C; Pesapane A; Montuori N; Ragno P; Martucci NM; Masullo M; De Vendittis E; Novellino E
    J Med Chem; 2012 May; 55(9):4142-58. PubMed ID: 22524450
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.
    Li Y; Yu Y; Jin K; Gao L; Luo T; Sheng L; Shao X; Li J
    Bioorg Med Chem Lett; 2014 Sep; 24(17):4125-8. PubMed ID: 25124112
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases.
    Valente S; Bana E; Viry E; Bagrel D; Kirsch G
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5827-30. PubMed ID: 20800482
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 2,4-Dihydroxychalcone derivatives as novel potent cell division cycle 25B phosphatase inhibitors and protein tyrosine phosphatase 1B inhibitors.
    Xie C; Sun Y; Pan CY; Tang LM; Guan LP
    Pharmazie; 2014 Apr; 69(4):257-62. PubMed ID: 24791588
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors.
    Kolb S; Mondésert O; Goddard ML; Jullien D; Villoutreix BO; Ducommun B; Garbay C; Braud E
    ChemMedChem; 2009 Apr; 4(4):633-48. PubMed ID: 19212959
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.