BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 34428735)

  • 1. Intrinsic relative preference profile of pan-kinase inhibitor drug staurosporine towards the clinically occurring gatekeeper mutations in Protein Tyrosine Kinases.
    Ren Z; Li Q; Shen Y; Meng L
    Comput Biol Chem; 2021 Oct; 94():107562. PubMed ID: 34428735
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Systematic response of staurosporine scaffold-based inhibitors to drug-resistant cancer kinase mutations.
    He Y
    Arch Pharm (Weinheim); 2020 Jun; 353(6):e1900320. PubMed ID: 32285482
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Systematic profiling of staralog response to acquired drug resistant kinase gatekeeper mutations in targeted cancer therapy.
    Yang Y; Qiu Y; Liu X; Liu Y; Yin Y; Li P
    Amino Acids; 2020 Apr; 52(4):511-521. PubMed ID: 32206932
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology.
    Song X; Liu X; Ding X
    J Mol Recognit; 2017 Apr; 30(4):. PubMed ID: 27891677
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Systematic Analysis of Tyrosine Kinase Inhibitor Response to RET Gatekeeper Mutations in Thyroid Cancer.
    Meng S; Wu H; Wang J; Qiu Q
    Mol Inform; 2016 Oct; 35(10):495-505. PubMed ID: 27712045
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular insight into the T798M gatekeeper mutation-caused acquired resistance to tyrosine kinase inhibitors in ErbB2-positive breast cancer.
    Lu J; Zhou K; Yin X; Xu H; Ma B
    Comput Biol Chem; 2019 Feb; 78():290-296. PubMed ID: 30605854
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Integrated Exploitation of the Structural Diversity Space of Chemotherapy Drugs to Selectively Inhibit HER2 T798M Mutant in Lung Cancer.
    Wang YW; Zhang HY; Li JS; Wang XW
    Chem Biodivers; 2017 Mar; 14(3):. PubMed ID: 27696725
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy.
    Sohl CD; Ryan MR; Luo B; Frey KM; Anderson KS
    ACS Chem Biol; 2015 May; 10(5):1319-29. PubMed ID: 25686244
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.
    Mohanty S; Oruganty K; Kwon A; Byrne DP; Ferries S; Ruan Z; Hanold LE; Katiyar S; Kennedy EJ; Eyers PA; Kannan N
    PLoS Genet; 2016 Feb; 12(2):e1005885. PubMed ID: 26925779
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural basis for the inhibitor recognition of human Lyn kinase domain.
    Miyano N; Kinoshita T; Nakai R; Kirii Y; Yokota K; Tada T
    Bioorg Med Chem Lett; 2009 Dec; 19(23):6557-60. PubMed ID: 19857964
    [TBL] [Abstract][Full Text] [Related]  

  • 11. On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine.
    Tanramluk D; Schreyer A; Pitt WR; Blundell TL
    Chem Biol Drug Des; 2009 Jul; 74(1):16-24. PubMed ID: 19519740
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Drug response to HER2 gatekeeper T798M mutation in HER2-positive breast cancer.
    Meng X; Li Y; Tang H; Mao W; Yang H; Wang X; Ding X; Xie S
    Amino Acids; 2016 Feb; 48(2):487-97. PubMed ID: 26439378
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state.
    Besch A; Marsiglia WM; Mohammadi M; Zhang Y; Traaseth NJ
    Proc Natl Acad Sci U S A; 2023 Feb; 120(8):e2213090120. PubMed ID: 36791110
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
    Mohi MG; Boulton C; Gu TL; Sternberg DW; Neuberg D; Griffin JD; Gilliland DG; Neel BG
    Proc Natl Acad Sci U S A; 2004 Mar; 101(9):3130-5. PubMed ID: 14976243
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An interaction map of small-molecule kinase inhibitors with anaplastic lymphoma kinase (ALK) mutants in ALK-positive non-small cell lung cancer.
    Ai X; Shen S; Shen L; Lu S
    Biochimie; 2015 May; 112():111-20. PubMed ID: 25769414
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A general framework for inhibitor resistance in protein kinases.
    Balzano D; Santaguida S; Musacchio A; Villa F
    Chem Biol; 2011 Aug; 18(8):966-75. PubMed ID: 21867912
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Functional characterization of peanut serine/threonine/tyrosine protein kinase: molecular docking and inhibition kinetics with tyrosine kinase inhibitors.
    Rudrabhatla P; Rajasekharan R
    Biochemistry; 2004 Sep; 43(38):12123-32. PubMed ID: 15379551
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Protein kinase inhibition of clinically important staurosporine analogues.
    Gani OA; Engh RA
    Nat Prod Rep; 2010 Apr; 27(4):489-98. PubMed ID: 20336234
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Fishing wild-type sparing inhibitors of proto-oncogene c-met variants in renal cell carcinoma from a curated tyrosine kinase inhibitor pool using analog-sensitive kinase technology.
    Wang Z; Jiang M; Feng N; Li C
    Biochimie; 2018 Sep; 152():188-197. PubMed ID: 30017898
    [TBL] [Abstract][Full Text] [Related]  

  • 20. ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17-Mutant KIT.
    Apsel Winger B; Cortopassi WA; Garrido Ruiz D; Ding L; Jang K; Leyte-Vidal A; Zhang N; Esteve-Puig R; Jacobson MP; Shah NP
    Cancer Res; 2019 Aug; 79(16):4283-4292. PubMed ID: 31270078
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.